The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models

Neuroendocrinology

Volumn 84, Issue 5, 2007, Pages 330-338

  Maswood, Navin ^a   Cosmi, Scott ^a   Alfinito, Peter D ^a   Leventhal, Liza ^a   Deecher, Darlene C ^a  

^a PFIZER INC   (United States)

Author keywords

Core body temperature; Hot flush; Hypothalamus; Neuroendocrine axis; Norepinephrine; Serotonin; Temperature regulation

Indexed keywords

FLUOXETINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NALOXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE DISORDER; CONTROLLED STUDY; CORE TEMPERATURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SKIN TEMPERATURE; TELEMETRY; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEMALE; FLUOXETINE; HOT FLASHES; MORPHINE DEPENDENCE; NALOXONE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN UPTAKE INHIBITORS; TELEMETRY;

EID: 33947103782     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000098322     Document Type: Article

References (52)

1. Deecher DC: Physiology of thermoregulatory dysfunction and current approaches to the treatment of vasomotor symptoms. Expert Opin Investig Drugs 2005;14:435-448.
2. Hensel H: Neural processes in thermoregulation. Physiol Rev 1973;53:948-1017.
3. Freedman RR, Benton MD, Genik RJ 2nd, Graydon FX: Cortical activation during menopausal hot flashes. Fertil Steril 2006;85:674-678.
4. Boulant JA, Dean JB: Temperature receptors in the central nervous system. Annu Rev Physiol 1986;48:639-654.
5. Hirata K, Nagasaka T, Hirai A, Hirashita M, Takahata T, Nunomura T: Effects of human menstrual cycle on thermoregulatory vasodilation during exercise. Eur J Appl Physiol Occup Physiol 1986;54:559-565.
6. Tankersley CG, Nicholas WC, Deaver DR, Mikita D, Kenney WL: Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heat. J Appl Physiol 1992;73:1238-1245.
7. Kolka MA, Stephenson LA: Resetting the thermoregulatory set-point by endogenous estradiol or progesterone in women. Ann NY Acad Sci 1997;813:204-206.
8. Stephenson LA, Kolka MA: Esophageal temperature threshold for sweating decreases before ovulation in premenopausal women. J Appl Physiol 1999;86:22-28.
9. Casper RF, Yen SS: Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clin Endocrinol 1985;22:293-312.
10. Shanafelt TD, Barton DL, Adjei AA, Loprinzi CL: Pathophysiology and treatment of hot flashes. Mayo Clin Proc 2002;77:1207-1218.
11. Kronenberg F: Hot Flashes. In: Treatment of the Postmenopausal Woman. Lobo RA (ed.), 2nd edition. Lippincott Williams &Wilkins, Philadelphia, Pa., 1999, pp 157-177.
12. Krajnak K, Rosewell KL, Duncan MJ, Wise PM: Aging, estradiol and time of day differentially affect serotonin transporter binding in the central nervous system of female rats. Brain Res 2003;990:87-94.
13. Rubinow DR, Schmidt PJ, Roca CA: Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry 1998;44:839-850.
14. Bethea CL, Gundlah C, Mirkes SJ: Ovarian steroid action in the serotonin neural system of macaques. Novartis Found Symp 2000;230:112-113.
15. Hjorth S: Hypothermia in rats induced by potent serotonergic agent 8-OH-DPAT. J Neural Transm 1985;61:131-135.
16. Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH: The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology 2003;44:1031-1037.
17. Hedlund PB, Kelly L, Mazur C, Lovenberg T, Sutcliffe JG, Bonaventure P: 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur J Pharmacol 2004;487:125-132.
18. Gudelsky GA, Koenig JI, Meltzer HY: Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors. Neuropharmacology 1986;25:1307-1313.
19. Salmi P, Ahlenius S: Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms. Pharmacol Toxicol 1998;82:122-127.
20. Berendsen HH, Kloosterboer HJ: Oestradiol and mirtazapine restore the disturbed tailtemperature of oestrogen-deficient rats. Eur J Pharmacol 2003;482:329-333.
21. Sipe K, Leventhal L, Burroughs K, Cosmi S, Johnston GH, Deecher DC: Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. Brain Res 2004;1028:191-202.
22. Loprinzi CL, Sloan JA, Perez EA, Quella SK, Stella PJ, Mailliard JA, Halyard MY, Pruthi S, Novotny PJ, Rummans TA: Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 2002;20:1578-1583.
23. Suvanto-Luukkonen E, Koivunen R, Sundstrom H, Bloigu R, Kaljalainen E, Haiva-Mallinen L, Tapanainen JS: Citalopram and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized, 9-month, placebo-controlled, double-blind study. Menopause 2005;12:18-26.
24. Berendsen HHG, Weekers AHJ, Kloosterboer HJ: Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats. Eur J Pharmacol 2001;419:47-54.
25. Leventhal L, Cosmi S, Deecher D: Effect of calcium channel modulators on temperature regulation in ovariectomized rats. Pharmacol Biochem Behav 2005;80:511-520.
26. Simpkins JW, Katovich MJ, Song IC: Similarities between morphine withdrawal in the rat and the menopausal hot flush. Life Sci 1983;32:1957-1966.
27. Katovich MJ, Simpkins JW, Berglund LA, O'Meara J: Regional skin temperature changes in a rat model for the menopausal hot flush. Maturitas 1986;8:67-76.
28. Koch S, Perry KW, Nelson DL, Conway RG, Threlkeld PG, Bymaster FP: R-fluoxetine increases extracellular DA, NE, as well as 5-HT in rat prefrontal cortex and hypothalamus: an in vivo microdialysis and receptor binding study. Neuropsychopharmacology 2002;27:949-959.
29. Merchenthaler I, Funkhouser JM, Carver JM, Lundeen SG, Ghosh K, Winneker RC: The effect of estrogens and antiestrogens in a rat model for hot flush. Maturitas 1998;30:307-316.
30. Harris RA, Loh HH, Way EL: Antinociceptive effects of lanthanum and cerium in nontolerant and morphine tolerant-dependent animals. J Pharmacol Exp Ther 1976;196:288-297.
31. Suzuki T, Fukagawa Y, Misawa M: Enhancement of morphine withdrawal signs in the rat after chronic treatment with naloxone. Eur J Pharmacol 1990;178:239-242.
32. Schnur P, Espinoza M, Flores R, Ortiz S, Vallejos S, Wainwright M: Blocking naloxone-precipitated withdrawal in rats and hamsters. Pharmacol Biochem Behav 1992;43:1093-1098.
33. Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH: Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther 2006;318:657-665.
34. Myers RD: Impairment of thermoregulation, food and water intakes in the rat after hypothalamic injections of 5,6-dihydroxytryptamine. Brain Res 1975;94:491-506.
35. Cox B, Davis A, Juxon V, Lee TF, Martin D: A role for an indoleamine other than 5-hydroxytryptamine in the hypothalamic thermoregulatory pathways of the rat. J Physiol 1983;337:441-450.
36. Ishiwata T, Saito T, Hasegawa H, Yazawa T, Otokawa M, Aihara Y: Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats. Life Sci 2004;75:2665-2675.
37. Bymaster FP, Zhang W, Carter PA, Shaw J, Chernet E, Phebus L, Wong DT, Perry KW: Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology 2002;160:353-361.
38. Sanchez C, Hyttel J: Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol 1999;19:467-489.
39. Beyer CE, Boikess S, Luo B, Dawson LA: Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. J Psychopharmacol 2002;16:297-304.
40. Chaput Y, de Montigny C, Blier P: Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 1986;333:342-348.
41. Jolas T, Haj-Dahmane S, Kidd EJ, Langlois X, Lanfumey L, Fattaccini CM, Vantalon V, Laporte AM, Adrien J, Gozlan H, et al: Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J Pharmacol Exp Ther 1994;268:1432-1443.
42. Kreiss DS, Lucki I: Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J Pharmacol Exp Ther 1995;274:866-876.
43. Le Poul E, Laaris N, Doucet E, Laporte AM, Hamon M, Lanfumey L: Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Arch Pharmacol 1995;352:141-148.
44. Le Poul E, Boni C, Hanoun N, Laporte AM, Laaris N, Chauveau J, Hamon M, Lanfumey L: Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 2000;39:110-122.
45. Romero L, Hervas I, Artigas F: The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci Lett 1996;219:123-126.
46. Dawson LA, Nguyen HQ: Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. Eur J Pharmacol 1998;345:41-46.
47. Schober CE, Ansani NT: Venlafaxine hydrochloride for the treatment of hot flashes. Ann Pharmacother 2003;37:1703-1707.
48. Loprinzi CL, Pisansky TM, Fonseca R, Sloan JA, Zahasky KM, Quella SK, Novotny PJ, Rummans TA, Dumesic DA, Perez EA: Pilot evaluation of venlafaxine hydrochloride for the therapy of hot flashes in cancer survivors. J Clin Oncol 1998;16:2377-2381.
49. Feldberg W, Myers RD: A new concept of temperature regulation by amines in the hypothalamus. Nature 1963;4913:1325.
50. Gordon CJ, Heath JE: Effect of monoamines on firing rate and thermal sensitivity of neurons in the preoptic area of awake rabbits. Exp Neurol 1981;72:352-365.
51. Myers RD: Neurochemistry of thermoregulation. Physiologist 1984;27:41-46.
52. Clark WG, Lipton JM: Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II. Neurosci Biobehav Rev 1986;10:153-220.