Nuclear targeting of non-viral gene carriers using psoralen-nuclear localization signal (NLS) conjugates

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 66, Issue 1, 2007, Pages 28-33

  Yoo, Hyuk Sang ^a   Jeong, Seo Young ^b  

^a Kangwon National University   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Nuclear localization signal; PEI; Psoralen; Transfection

Indexed keywords

DNA; GLYCYLGLYCYLGLYCYLPROLYLLYSYLLYSYLLYSYLARGINYLLYSYLVALINE; GLYCYLGLYCYLGLYCYLPROLYLLYSYLTHREONYLLYSYLARGINYLLYSYLVALINE; INTERCALATING AGENT; POLYETHYLENEIMINE; PSORALEN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL NUCLEUS; CELL STRAIN COS1; CHEMICAL STRUCTURE; CULTURE MEDIUM; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG TARGETING; GENETIC TRANSFECTION; INTERCALATION COMPLEX; LIGHT SCATTERING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR LOCALIZATION SIGNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; TRANSGENE;

AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; FICUSIN; IMINES; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; NUCLEAR LOCALIZATION SIGNALS; PHOTOSENSITIZING AGENTS; POLYAMINES; POLYETHYLENES; PSORALENS; SUCCINIMIDES; TRANSFECTION;

EID: 33947103558     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.09.013     Document Type: Article

References (21)

1. Ledley F.D. Non viral gene therapy: the promise of genes as pharmaceutical products. Hum. Gene Ther. 6 (1995) 1129-1144
2. Leong K.W., Mao H.-Q., Truong-Le V.L., Roy K., Walsh S.M., and August J.T. DNA-polycation nanospheres as non-viral gene delivery vehicles. J. Controlled Release 53 (1998) 183-193
3. Kamiya H., Tsuchiya H., Yamazaki J., and Harashima H. Intracellular trafficking and transgene expression of viral and nonviral vectors. Adv. Drug. Del. Rev. 52 (2001) 153-164
4. Zabner J., Fasbender A.J., Moninger T., Poellinger K.A., and Welsh M.J. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 270 (1995) 18997-19007
5. Ludtke J.J., Sebestyen M.G., and Wolff J.A. The effect of cell division on the cellular dynamics of microinjected DNA and dextran. Mol. Ther. 5 (2002) 579-588
6. Ciolina C., Byk G., Blanche F., Thuillier V., Scherman D., and Wils P. Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin γ. Bioconjugate Chem. 10 (1999) 49-55
7. Sebestyen M.G., Ludtke J.J., Bassik M.C., Zhang G., Budker V., Lukhtanov E.A., Hagstrom J.E., and Wolff J.A. DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA. Nat. Biotechnol. 16 (1998) 80-85
8. Cartie R., and Reszka R. Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems. Gene Ther. 9 (2002) 157-167
9. Zanta M.A., Belguise-Valladier P., and P Behr J. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc. Natl. Acad. Sci. USA 96 (1999) 91-96
10. Mirzayans R., Remy A.A., and Malcolm P.C. Differential expression and stability of foreign genes introduced into human fibroblasts by nuclear versus cytoplasmic microinjection. Mutat. Res. 281 (1992) 115-122
11. Nagasaki T., Myohoji T., Tachibana T., Futaki S., and Tamagaki S. Can nuclear localization signals enhance nuclear localization of plasmid DNA?. Bioconjugate Chem. 14 (2003) 282-286
12. Branden L.J., Mohamed A.J., and Smith C.I. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat. Biotechnol. 17 (1999) 784-787
13. Lee H., Jeong J.H., and Park T.G. A new gene delivery formulation of polyethyleneimine/DNA complexes coated with PEG conjugated fusogenic peptide. J. Controlled Release 76 (2001) 183-192
14. Yoo H.S., Lee J.E., Chung H., Kwon I.C., and Jeong S.Y. Self-assembled nanoparticles containing hydrophobically-modified glycol chitosan for gene delivery. J. Controlled Release 103 (2005) 235-243
15. Yoo H.S., Kwon S.M., Kim Y.J., Chung H., Kwon I.C., Kim J., and Jeong S.Y. Cationic lipid emulsion containing heavy oil for the transfection of adherent cells. J. Controlled Release 98 (2004) 179-188
16. Leahy P., Carmichael G.G., and Rossomando E.F. Novel biotinylated plasmid expression vectors retain biological function and can bind streptavidin. Bioconjugate Chem. 7 (1996) 545-551
17. Boulanger C., Di Giorgio C., and Vierling P. Synthesis of acridine-nuclear localization signal (NLS) conjugates and evaluation of their impact on lipoplex and polyplex-based transfection. Eur. J. Med. Chem. 40 (2005) 1295-1306
18. Honor'e I., Grosse S., Frison N., Favatier F., Monsigny M., and Fajac I. Transcription of plasmid DNA: influence of plasmid DNA/polyethylenimine complex formation. J. Control Release 107 (2005) 537-546
19. Grosse S., Thévenot G., Monsigny M., and Fajac I. Which mechanism for nuclear import of plasmid DNA complexed with polyethylenimine derivatives?. J. Gene Med. 8 (2006) 845-851
20. Dean D.A., Strong D.D., and Zimmer W.E. Nuclear entry of nonviral vectors. Gene Ther. 12 (2005) 881-890
21. Oh Y.K., Suh D., Kim J.M., Choi H.G., Shin K., and Ko J.J. Polyethylenimine mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA. Gene Ther. 9 (2002) 1627-1632