Synthesis of psoralen derivatives and their blocking effect of hKv1.5 channel

Archives of Pharmacal Research

Volumn 30, Issue 2, 2007, Pages 155-160

  Jae, Soon Eun ^a   Kwang, Sik Kim ^a   Han, Na Kim ^b   Seon, Ah Park ^b   Ma, Tian Ze ^b   Lee, Kyung A ^a   Dae, Keun Kim ^a   Hyung, Kyo Kim ^c   In, Su Kim ^c   Young, Hoon Jung ^c   Ok, Pyo Zee ^c   Dong, Jin Yoo ^d   Yong, Geun Kwak ^b  

^a Woosuk University   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Seonam University   (South Korea)

Author keywords

Antiarrhythmic drug; hKv1.5 channel blocker; Psoralen derivatives

Indexed keywords

EID: 33947095930     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02977688     Document Type: Article

References (14)

1. Carneiro, L. V., Ferreira, S. R., Chen, C. L., and Andreu, G. L., Psoralen derivatives and longwave ultraviolet irradiation are activie in vitro against human melanoma cell line. J. Photochem. Photobiol. B., 76, 49-53 (2004).
2. Eun, J. S., Choi, B. H., Park, J. A., Lee, G. I., Lee, T. Y., Kim, D. K., Jung, Y. H., Yoo, D. J., and Kwak, Y. G., Open channel block of hKv1.5 by psoralen from Heracleum moellendorffii Hance. Arch. Pharm. Res., 28, 269-273 (2005).
3. + channel gating: cloned delayed rectifier mechanisms and drug modulation. Can. J. Physiol. Pharmacol., 76, 77-89 (1998).
4. Kostovic, K., Nola, I., Bucan, Z., and Situm, M., Treatment of vitiligo: current methods and new approaches. Acta. Dermatovenerol Croat., 11, 163-170 (2003).
5. + channel function by the Kvbeta 1.3 subunit. J. Biol. Chem., 274, 25355-25361 (1999).
6. Okamoto, A., Tanabe, K., and Saito, I., Synthesis and properties of peptide nucleic acids containing a psoralen Unit. Org. Lett., 3, 925-927 (2001).
7. Roden, D. M., Mechanism and management of proarrhythmia. Am. J. Cardiol., 82, 491-571 (1998).
8. Roden, D. M. and George, A. J. Jr., The cardiac ion channel: relevance to management of arrhythmias. Annu. Rev. Med., 47, 138-148 (1999).
9. Smith, M. L., Gregory, P., Bafi-Yeboa, N. F., and Arnason, J. T., Inhibition of DNA polymerization and antifungal specificity of furanocoumarins present in traditional medicines. Photochem. Photobiol., 79, 506-509 (2004).
10. Snyders, D. J., Knoth, K. M., Roberts, S. L., and Tamkun, M. M., Time-, voltage, and state-dependent block by quinidine of a cloned human cardiac potassium channel. Mol. Pharmacol., 41, 322-330 (1992).
11. Snyders, D. J., Tamkun, M. M., and Bennett, P. B., A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. J. Gen. Physiol., 101, 513-543 (1993).
12. Vennekamp, J., Wulff, H., Beeton, C., Calabresi, P. A., Grissmer, S., Hansel, W., and Chandy, G., Kv1.3-blocking 5-phenylalkoxypsorelens: A new class of immunomodulators. Mol. Pharmacol., 65, 1364-1374 (2004).
13. + current similar to Kv1.5 cloned channel currents. Circ. Res., 73, 1061-1076 (1993).
14. Wang, Z., Fermini, B., and Nattel, S., Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc. Res., 28, 1540-1546 (1994).