Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes

Journal of Leukocyte Biology

Volumn 81, Issue 3, 2007, Pages 581-583

  Payne, Felicity ^a,b   Cooper, Jason D ^a   Walker, Neil M ^a   Lam, Alex C ^a   Smink, Luc J ^a   Nutland, Sarah ^a   Stevens, Helen E ^a   Hutchings, Jayne ^a   Todd, John A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

CBLB; CTLA4; rs3087243; rs3772534; Type 1 diabetes

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ALLELE; ARTICLE; CBLB GENE; CONTROLLED STUDY; EXON; FAMILY HISTORY; GENE INTERACTION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CASE-CONTROL STUDIES; DENMARK; DIABETES MELLITUS, TYPE 1; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-CBL; RATS;

EID: 33847788799     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0906577     Document Type: Article

References (8)

1. Yokoi, N., Komeda, K., Wang, H. Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. (2002) Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat. Genet. 31, 391-394.
2. Chapman, J. M., Cooper, J. D., Todd, J. A., Clayton, D. G. (2003) Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum. Hered. 56, 18-31.
3. Payne, F., Smyth, D. J., Pask, R., Barratt, B. J., Cooper, J. D., Twells, R. C., Walker, N. M., Lam, A. C., Smink, L. J., Nutland, S., et al. (2004) Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb. Diabetes 53, 505-509.
4. Bergholdt, R., Taxvig, C., Eising, S., Nerup, J., Pociot, F. (2005) CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. J. Leukoc. Biol. 77, 579-585.
5. Clayton, D. G., Walker, N. M., Smyth, D. J., Pask, R., Cooper, J. D., Maier, L. M., Smink, L. J., Lam, A. C., Ovington, N. R., Stevens, H. E., et al. (2005) Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat. Genet. 37, 1243-1246.
6. Howson, J. M., Barratt, B. J., Todd, J. A., Cordell, H. J. (2005) Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci. Genet. Epidemiol. 29, 51-67.
7. Todd, J. A. (2006) Statistical false positive or true disease pathway? Nat. Genet. 38, 731-733.
8. Huber, P. (1972) Robust statistics: a review. Ann. Math. Statist. 43, 1041-1067.