메뉴 건너뛰기




Volumn 2, Issue 2, 2006, Pages 273-283

Sex differences in pharmacokinetics and toxicity of antiretroviral therapy

Author keywords

Antiretroviral therapy; Gender; Pharmacokinetics; Toxicity

Indexed keywords

ANTIRETROVIRUS AGENT;

EID: 33847761503     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2.2.273     Document Type: Review
Times cited : (43)

References (49)
  • 1
    • 1442314509 scopus 로고    scopus 로고
    • Heterosexual Tranmission Of HIV - 29 States, 1999-2002
    • CENTERS FOR DISEASE CONTROL AND PREVENTION CDC
    • CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC): Heterosexual Tranmission Of HIV - 29 States, 1999-2002. MMWR Morb. Mortal. Wkly Rep. (2004) 53(06):125-129.
    • (2004) MMWR Morb. Mortal. Wkly Rep , vol.53 , Issue.6 , pp. 125-129
  • 2
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    • GULICK RM, RIBAUDO HJ, SHIKUMA CM et al.: Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N. Engl. J. Med. (2004) 350(18):1850-1861.
    • (2004) N. Engl. J. Med , vol.350 , Issue.18 , pp. 1850-1861
    • GULICK, R.M.1    RIBAUDO, H.J.2    SHIKUMA, C.M.3
  • 3
    • 0037007681 scopus 로고    scopus 로고
    • Participation in research and access to experimental treatments by HIV-infected patients
    • GIFFORD AL, CUNNINGHAM WE, HESLIN KC et al.: Participation in research and access to experimental treatments by HIV-infected patients. N. Engl. J. Med. (2002) 346(18):1373-1382.
    • (2002) N. Engl. J. Med , vol.346 , Issue.18 , pp. 1373-1382
    • GIFFORD, A.L.1    CUNNINGHAM, W.E.2    HESLIN, K.C.3
  • 4
    • 0242333229 scopus 로고    scopus 로고
    • Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals
    • ANDERSON PL, KAKUDA TN, KAWLE S, FLETCHER CV: Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. AIDS (2003) 17(15):2159-2168.
    • (2003) AIDS , vol.17 , Issue.15 , pp. 2159-2168
    • ANDERSON, P.L.1    KAKUDA, T.N.2    KAWLE, S.3    FLETCHER, C.V.4
  • 5
    • 0032908463 scopus 로고    scopus 로고
    • Population pharmacokinetics of nevirapine, zidovudine and didanosine in human immunodeficiency virus-infected patients. The National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators
    • ZHOU XJ, SHEINER LB, D'AQUILA RT et al.: Population pharmacokinetics of nevirapine, zidovudine and didanosine in human immunodeficiency virus-infected patients. The National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. Antimicrob. Agents Chemother. (1999) 43(1):121-128.
    • (1999) Antimicrob. Agents Chemother , vol.43 , Issue.1 , pp. 121-128
    • ZHOU, X.J.1    SHEINER, L.B.2    D'AQUILA, R.T.3
  • 8
    • 0037226529 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398
    • PFISTER M, LABBE L, HAMMER SM et al.: Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398. Antimicrob. Agents Chemother. (2003) 47(1):130-137.
    • (2003) Antimicrob. Agents Chemother , vol.47 , Issue.1 , pp. 130-137
    • PFISTER, M.1    LABBE, L.2    HAMMER, S.M.3
  • 9
    • 0013004863 scopus 로고    scopus 로고
    • Effects of gender, race, age and weight on the pharmacokinetics of lopinavir (lopinavir/ritonavir) in healthy adult subjects™ after single-dose kaletra
    • Noordwijk, The Netherlands ():Abstract 3.12
    • BERTZ R, LAM W, HSU A, GRANNEMAN GR, SUN E: Effects of gender, race, age and weight on the pharmacokinetics of lopinavir (lopinavir/ritonavir) in healthy adult subjects™ after single-dose kaletra. Proceedings of the 2nd International Workshop on Clinical Pharmacology of HIV therapy. Noordwijk, The Netherlands (2001):Abstract 3.12.
    • (2001) Proceedings of the 2nd International Workshop on Clinical Pharmacology of HIV therapy
    • BERTZ, R.1    LAM, W.2    HSU, A.3    GRANNEMAN, G.R.4    SUN, E.5
  • 10
    • 34547914412 scopus 로고    scopus 로고
    • Lack of effect of gender, age, weight and body mass index on trough lopinavir plasma concentrations in HIV-pretreated patients treated with Kaletra
    • Cannes, France ():Abstract 6.12
    • POIRIER JM, ZOUAI O, MEYNARD JL et al.: Lack of effect of gender, age, weight and body mass index on trough lopinavir plasma concentrations in HIV-pretreated patients treated with Kaletra. Proceedings of the 4th International Workshop on Clinical Pharmacology of HIV therapy. Cannes, France (2003):Abstract 6.12.
    • (2003) Proceedings of the 4th International Workshop on Clinical Pharmacology of HIV therapy
    • POIRIER, J.M.1    ZOUAI, O.2    MEYNARD, J.L.3
  • 11
    • 33847759514 scopus 로고    scopus 로고
    • BURGER DM, MULLER RJ, VAN DE LEUR MR, LA PORTE CJL: Lopinavir plasma levels are significantly higher in female than in male HIV-1 infected patients. Proceedings of the 3rd International Workshop on Clinical Pharmacology of HIV therapy. Washington DC, USA (2002):Abstract 6.5.
    • BURGER DM, MULLER RJ, VAN DE LEUR MR, LA PORTE CJL: Lopinavir plasma levels are significantly higher in female than in male HIV-1 infected patients. Proceedings of the 3rd International Workshop on Clinical Pharmacology of HIV therapy. Washington DC, USA (2002):Abstract 6.5.
  • 13
    • 2342563028 scopus 로고    scopus 로고
    • Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1
    • PAI MP, SCHRIEVER CA, DIAZ-LINARES M, NOVAK RM, RODVOLD KA: Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1. Pharmacotherapy. (2004) 24(5):592-599.
    • (2004) Pharmacotherapy , vol.24 , Issue.5 , pp. 592-599
    • PAI, M.P.1    SCHRIEVER, C.A.2    DIAZ-LINARES, M.3    NOVAK, R.M.4    RODVOLD, K.A.5
  • 14
    • 1842450852 scopus 로고    scopus 로고
    • Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359
    • FLETCHER CV, JIANG H, BRUNDAGE RC et al.: Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359. J. Infect. Dis. (2004) 189(7):1176-1184.
    • (2004) J. Infect. Dis , vol.189 , Issue.7 , pp. 1176-1184
    • FLETCHER, C.V.1    JIANG, H.2    BRUNDAGE, R.C.3
  • 15
    • 27744448646 scopus 로고    scopus 로고
    • The impact of gender on saquinavir hard-gel/ritonavir (1000/100 mg b.i.d.) pharmacokinetics and PBMC transporter expression in HIV-1 infected individuals
    • Quebec City, Canada ():Abstract 9
    • DICKINSON L, BACK D, CHANDLER B et al.: The impact of gender on saquinavir hard-gel/ritonavir (1000/100 mg b.i.d.) pharmacokinetics and PBMC transporter expression in HIV-1 infected individuals. Proceedings of the 6th International Workshop on Clinical Pharmacology of HIV therapy. Quebec City, Canada (2005):Abstract 9.
    • (2005) Proceedings of the 6th International Workshop on Clinical Pharmacology of HIV therapy
    • DICKINSON, L.1    BACK, D.2    CHANDLER, B.3
  • 18
    • 0038101663 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients
    • BURGER D, BOYD M, DUNCOMBE C et al.: Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients. J. Antimicrob. Chemother. (2003) 51(5):1231-1238.
    • (2003) J. Antimicrob. Chemother , vol.51 , Issue.5 , pp. 1231-1238
    • BURGER, D.1    BOYD, M.2    DUNCOMBE, C.3
  • 19
    • 7244243920 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of a double-boosting regimen of saquinavir soft gel plus lopinavir plus mini-dose ritonavir in human immunodeficiency virus-infected adults
    • RIBERA E, LOPEZ RM, DIAZ M et al.: Steady-state pharmacokinetics of a double-boosting regimen of saquinavir soft gel plus lopinavir plus mini-dose ritonavir in human immunodeficiency virus-infected adults. Antimicrob. Agents Chemother. (2004) 48(11):4256-4262.
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.11 , pp. 4256-4262
    • RIBERA, E.1    LOPEZ, R.M.2    DIAZ, M.3
  • 20
    • 20444470810 scopus 로고    scopus 로고
    • Population pharmacokinetics and exposure-response relationship of enfurvirtide in treatment-experienced human immunodeficiency virus type 1-infected patients
    • MOULD DR, ZHANG X, NIEFORTH K, SALGO M, BUSS N, PATEL IH: Population pharmacokinetics and exposure-response relationship of enfurvirtide in treatment-experienced human immunodeficiency virus type 1-infected patients. Clin. Pharmacol. Ther. (2005) 77(6):515-528.
    • (2005) Clin. Pharmacol. Ther , vol.77 , Issue.6 , pp. 515-528
    • MOULD, D.R.1    ZHANG, X.2    NIEFORTH, K.3    SALGO, M.4    BUSS, N.5    PATEL, I.H.6
  • 21
    • 0037647146 scopus 로고    scopus 로고
    • Sex differences in adverse reactions to antiretroviral drugs
    • OFOTOKUN I, POMEROY C: Sex differences in adverse reactions to antiretroviral drugs. Top. HIV Med. (2003) 11(2):55-59.
    • (2003) Top. HIV Med , vol.11 , Issue.2 , pp. 55-59
    • OFOTOKUN, I.1    POMEROY, C.2
  • 22
    • 0030199251 scopus 로고    scopus 로고
    • Adverse events from drug therapy for human immunodeficiency virus disease
    • MOORE RD, FORTGANG I, KERULY J, CHAISSON RE: Adverse events from drug therapy for human immunodeficiency virus disease. Am. J. Med. (1996) 101(1):34-40.
    • (1996) Am. J. Med , vol.101 , Issue.1 , pp. 34-40
    • MOORE, R.D.1    FORTGANG, I.2    KERULY, J.3    CHAISSON, R.E.4
  • 23
    • 0034253002 scopus 로고    scopus 로고
    • + responses to nucleoside analogue therapy for HIV infection. The Aids Clinical Trials Group 175 Team
    • + responses to nucleoside analogue therapy for HIV infection. The Aids Clinical Trials Group 175 Team. J. Acquir. Immune Defic. Syndr. (2000) 24(4):316-324.
    • (2000) J. Acquir. Immune Defic. Syndr , vol.24 , Issue.4 , pp. 316-324
    • CURRIER, J.S.1    SPINO, C.2    GRIMES3
  • 25
    • 0037685663 scopus 로고    scopus 로고
    • Prospective study of hyperlipidemia in ART-naïve subjects taking combivir/abacavir (COM/ABC), COM/nelfinavir (NFV), or stavudine (d4T)/lamivudine (3TC)/NFV (ESS40002)
    • Seattle, US ():Abstract 33
    • KUMAR P, RODRIGUEZ-FRENCH A, THOMPSON M et al.: Prospective study of hyperlipidemia in ART-naïve subjects taking combivir/abacavir (COM/ABC), COM/nelfinavir (NFV), or stavudine (d4T)/lamivudine (3TC)/NFV (ESS40002). Proceedings of the 9th Conference on Retroviruses and Opportunistic Infections. Seattle, US (2002):Abstract 33.
    • (2002) Proceedings of the 9th Conference on Retroviruses and Opportunistic Infections
    • KUMAR, P.1    RODRIGUEZ-FRENCH, A.2    THOMPSON, M.3
  • 27
    • 0037178329 scopus 로고    scopus 로고
    • Female sex, but not ethnicity, is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash
    • MAZHUDE C, JONES S, MURAD S, TAYLOR C, EASTERBROOK P: Female sex, but not ethnicity, is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash. AIDS (2002) 16(11):1566-1568.
    • (2002) AIDS , vol.16 , Issue.11 , pp. 1566-1568
    • MAZHUDE, C.1    JONES, S.2    MURAD, S.3    TAYLOR, C.4    EASTERBROOK, P.5
  • 28
    • 20044382589 scopus 로고    scopus 로고
    • Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects
    • SANNE I, MOMMEJA-MARIN H, HINKLE J et al.: Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects. J. Infect. Dis. (2005) 191(6):825-829.
    • (2005) J. Infect. Dis , vol.191 , Issue.6 , pp. 825-829
    • SANNE, I.1    MOMMEJA-MARIN, H.2    HINKLE, J.3
  • 30
    • 0033587510 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions
    • LUCAS GM, CHAISSON RE, MOORE RD: Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions. Ann. Intern. Med. (1999) 131(2):81-87.
    • (1999) Ann. Intern. Med , vol.131 , Issue.2 , pp. 81-87
    • LUCAS, G.M.1    CHAISSON, R.E.2    MOORE, R.D.3
  • 32
    • 0344256537 scopus 로고    scopus 로고
    • Risk factors for lipodystrophy in the CISAI cohort
    • BONFANTI P, GULISANO C, RICCI E et al.: Risk factors for lipodystrophy in the CISAI cohort. Biomed. Pharmacother. (2003) 57(9):422-427.
    • (2003) Biomed. Pharmacother , vol.57 , Issue.9 , pp. 422-427
    • BONFANTI, P.1    GULISANO, C.2    RICCI, E.3
  • 33
    • 0035853438 scopus 로고    scopus 로고
    • Sex differences in HAART-associated dyslipidemia
    • PERNERSTORFER-SCHOEN H, JILMA B, PERSCHLER A: Sex differences in HAART-associated dyslipidemia. AIDS (2001) 15(6):725-734.
    • (2001) AIDS , vol.15 , Issue.6 , pp. 725-734
    • PERNERSTORFER-SCHOEN, H.1    JILMA, B.2    PERSCHLER, A.3
  • 35
    • 0030961378 scopus 로고    scopus 로고
    • Delayed gastric emptying and decreased antral contractility in normal premenopausal women compared with men
    • KNIGHT LC, PARKMAN HP, BROWN KL et al.: Delayed gastric emptying and decreased antral contractility in normal premenopausal women compared with men. Am. J. Gastroenterol. (1997) 92(6):968-975.
    • (1997) Am. J. Gastroenterol , vol.92 , Issue.6 , pp. 968-975
    • KNIGHT, L.C.1    PARKMAN, H.P.2    BROWN, K.L.3
  • 36
    • 0032213101 scopus 로고    scopus 로고
    • Effect of estradiol on rat ileum
    • PINES A, ECKSTEIN N, DOTAN I et al.: Effect of estradiol on rat ileum. Gen. Pharmacol. (1998) 31(5):735-736.
    • (1998) Gen. Pharmacol , vol.31 , Issue.5 , pp. 735-736
    • PINES, A.1    ECKSTEIN, N.2    DOTAN, I.3
  • 37
    • 0035045273 scopus 로고    scopus 로고
    • Gender differences in pharmacokinetics of alcohol
    • BARAONA E, ABITTAN CS, DOHMEN K et al.: Gender differences in pharmacokinetics of alcohol. Alcohol. Clin. Exp. Res. (2001) 25(4):502-507.
    • (2001) Alcohol. Clin. Exp. Res , vol.25 , Issue.4 , pp. 502-507
    • BARAONA, E.1    ABITTAN, C.S.2    DOHMEN, K.3
  • 38
    • 14044276929 scopus 로고    scopus 로고
    • Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression
    • PAINE MF, LUDINGTON SS, CHEN ML et al.: Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression. Drug Metab. Dispos. (2005) 33(3):426-433.
    • (2005) Drug Metab. Dispos , vol.33 , Issue.3 , pp. 426-433
    • PAINE, M.F.1    LUDINGTON, S.S.2    CHEN, M.L.3
  • 39
    • 0021322739 scopus 로고
    • Sex-related differences in drug disposition in man
    • WILSON K: Sex-related differences in drug disposition in man. Clin. Pharmcokinet. (1984) 9(3):189-202.
    • (1984) Clin. Pharmcokinet , vol.9 , Issue.3 , pp. 189-202
    • WILSON, K.1
  • 40
    • 14644407562 scopus 로고    scopus 로고
    • Sex and racial differences in pharmacological response: Where is the evidence? Pharmacogenetics, pharmacokinetics and pharmacodynamics
    • ANDERSON GD: Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics and pharmacodynamics. J. Womens Health (Larchmt) (2005) 14(1):19-29.
    • (2005) J. Womens Health (Larchmt) , vol.14 , Issue.1 , pp. 19-29
    • ANDERSON, G.D.1
  • 41
    • 0037349259 scopus 로고    scopus 로고
    • The distribution and gender difference of CYP3A activity in Chinese subjects
    • ZHU B, LIU ZQ, CHEN GL et al.: The distribution and gender difference of CYP3A activity in Chinese subjects. Br. J. Clin. Pharmacol. (2003) 55(3):264-269.
    • (2003) Br. J. Clin. Pharmacol , vol.55 , Issue.3 , pp. 264-269
    • ZHU, B.1    LIU, Z.Q.2    CHEN, G.L.3
  • 42
    • 11944274532 scopus 로고    scopus 로고
    • The influence of age and sex on the clearance of cytochrome P450 3A substrates
    • COTREAU MM, VON MOLTKE LL, GREENBLATT DJ: The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin. Pharmacokinet. (2005) 44(1):33-60.
    • (2005) Clin. Pharmacokinet , vol.44 , Issue.1 , pp. 33-60
    • COTREAU, M.M.1    VON MOLTKE, L.L.2    GREENBLATT, D.J.3
  • 43
    • 0021152079 scopus 로고
    • Imipramine disposition in users of oral contraceptive steroids
    • ABERNETHY DR, GREENBLATT DJ, SHADER RI: Imipramine disposition in users of oral contraceptive steroids. Clin. Pharmacol. Ther. (1984) 35(6):792-797.
    • (1984) Clin. Pharmacol. Ther , vol.35 , Issue.6 , pp. 792-797
    • ABERNETHY, D.R.1    GREENBLATT, D.J.2    SHADER, R.I.3
  • 44
    • 0023038692 scopus 로고
    • Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid
    • MINERS JO, GRGURINOVICH N, WHITEHEAD AG, ROBSON RA, BIRKETT DJ: Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid. Br. J. Clin. Pharmacol. (1986) 22(2):135-142.
    • (1986) Br. J. Clin. Pharmacol , vol.22 , Issue.2 , pp. 135-142
    • MINERS, J.O.1    GRGURINOVICH, N.2    WHITEHEAD, A.G.3    ROBSON, R.A.4    BIRKETT, D.J.5
  • 45
    • 9644305194 scopus 로고    scopus 로고
    • December , UNAIDS
    • http://www.unaids.org/bangkok2004/GAR2004_pdf/Chapter2_globaloverview_en. pdf AIDS epidemic update: December (2004). UNAIDS.
    • (2004) AIDS epidemic update
  • 46
    • 33847745049 scopus 로고
    • guidelines on the inclusion of women and minorities as subjects in clinical research. NIH Guide
    • http://grants.nih.gov/grants/guide/notice-files/not94-100.html NIH guidelines on the inclusion of women and minorities as subjects in clinical research. NIH Guide (1994).
    • (1994)
  • 47
    • 33847733985 scopus 로고    scopus 로고
    • Publication
    • http://www.clinicaltrials.gov/ct/show/NCT00102986;jsessionid=CD7053FA063 4549133AA502A45286E61?order=3 Differences in blood levels of lopinavir/ritonavir in HIV-infected men and women. Clinical Trials.Gov Publication (2005).
    • (2005)
  • 48
    • 33847714154 scopus 로고    scopus 로고
    • http://www.fda.gov/cder/foi/label/2005/021814lbl.pdf Tipranavir package insert 2005
    • http://www.fda.gov/cder/foi/label/2005/021814lbl.pdf Tipranavir package insert (2005).
  • 49
    • 33847743440 scopus 로고    scopus 로고
    • http://www.fuzeon.com/common/fpi.pdf Fuzeon package insert 2005
    • http://www.fuzeon.com/common/fpi.pdf Fuzeon package insert (2005).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.