The impact of consanguinity on the Indian population

Indian Journal of Human Genetics

Volumn 8, Issue 2, 2002, Pages 45-51

  Bittles, A H ^a  

^a EDITH COWAN UNIVERSITY   (Australia)

Author keywords

Consanguineous marriage; Drift; Endogamy; India; Recessive disorders

Indexed keywords

EID: 33847745036     PISSN: 09716866     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Roychoudhury AK. Incidence of inbreeding in different states of India. Demography India 1976;5:108-19.
2. Roychoudhury AK. The incidence of affinal marriages in different states of India. Demography India 1979;8:211-6.
3. Singh B, Tyagi D. Studies on inbreeding in India. Hum Sci 1987;36:159-74.
4. Bhasin MK, Walter H, Danker-Hopfe H. The Distribution of Genetical, Morphological and Behavioural Traits among the Peoples of Indian Region. Delhi: Kamla-Raj;1992. pp-14-35.
5. Gadgil M, Joshi NV, Manoharan S, Patil S, Prasad UVS. Peopling of India. In: Balasubramanian D, Appaji Rao N. editors. The Indian Human Heritage. Hyderabad: Universities Press;1998. pp-100-29.
6. Majumder PP, Roy B, Banerjee S, Chakraborty M, Dey B, Muhkerjee N, et al. Human-specific insertion/deletion polymorphisms in India populations and their possible evolutionary implications. Eur J Hum Genet 1999;7:435-446.
7. Bamshad MJ, Kivisild T, Watkins WS, Dixon ME, Ricker CE, Rao, BB, et al. Genetic evidence on the origins of Indian caste populations. Genome Res 2001;11:1574-85.
8. Sanghvi LD. Inbreeding in India. Eugen Quart 1966;13:291-301.
9. nd edition. Calcutta: Oxford University Press; 1958. pp-117-37.
10. th edn Madras: Oxford University Press; 1976. p-66.
11. Bittles AH, Hussain R. An analysis of consanguineous marriage in the Muslim population of India at regional and state levels. Ann Hum Biol 2000;27:163-71.
12. UPS National Family and Health Survey, India, 1992-93. Bombay: International Institute for Population Sciences; 1995.
13. Rao PSS, Inbaraj SG. Inbreeding effects on fertility and sterility in southern India. J Med Genet 1979;16:24-31.
14. Bittles AH. Empirical Estimates of the Prevalence of Consanguineous Marriage in Contemporary Societies. Working Report no. 74, Morrison Institute for Population and Resource Studies, Stanford University, Stanford; 1998.
15. Bittles AH, Grant JC, Sullivan SG, Hussain R. Does inbreeding lead to decreased human fertility? Ann Hum Biol 2002;29:111-30.
16. Nair RR, Murthy JS. ABO blood group incompatibility and inbreeding effects: Evidence for an interaction. Hum Genet 1985;69:147-50.
17. Stern C, Charles DR. The Rhesus gene and the effect of consanguinity. Science 1945;101:305-307.
18. Stevenson AC, Davison BCC, Say B, Ustuoplu S, Liya D, Abul-Einem M, et al. Contribution of feto-maternal incompatibility to aetiology of pre-eclamptic toxaemia. Lancet 1971;ii:1286-9.
19. Clarke B, Kirby DRS. Maintenance of histocompatability polymorphisms. Nature 1966;211:999-1000.
20. Ober C. HLA and pregnancy:the paradox of the fetal allograft. Am J Hum Genet 1998;62:1-5.
21. Bittles AH, Mason WM, Greene J, Appaji Rao N. Reproductive behavior and health in consanguineous marriages. Science 1991;252:789-94.
22. Hussain R, Bittles AH, Sullivan S. Consanguinity and early mortality in the Muslim populations of India and Pakistan. Am J Hum Biol 2001;13:777-87.
23. Bittles AH, Neel JV. The costs of human inbreeding and their implications for variations at the DNA level. Nature Genet 1994;8:117-21.
24. Centerwall WR, Centerwall SA. Consanguinity and congenital anomalies in South lndia:a pilot study. Ind J Med Res 1966;54:1160-7.
25. Asha Bai PV, Jacob John T, Subramaniam VR. Reproductive wastage and developmental disorders in relation to consanguinity in South India. Trop Geog Med 1981;33:275-80.
26. Agarwal SS, Singh U, Singh PS, Singh SS, Das V, Sharma A, et al. Prevalence and spectrum of congenital malformations in a prospective study at a teaching hospital. Ind J Med Res [B] 1991;94:413-9.
27. Kulkarni ML, Mathew MA, Reddy V. The range of neural tube defects in southern India. Arch Dis Childh 1989;64:210-4.
28. Jain VK, Nalini P, Chandra R, Srinivasan S. Congenital malformations, reproductive wastage and consanguineous mating. Aust NZ J Obstet Gynaec 1993;33:33-6.
29. Badaruddoza, Afzal M, Akhtaruzzaman. Inbreeding and congenital heart disease in a North Indian population. Clin Genet 1994;45:288-291.
30. Gnanalingham MG, Gnanalingham KK, Singh A. Congenital heart disease and parental consanguinity in South India. Acta Paediat 1999;88:473-4.
31. Chen A, Wayne S, Bell A, Ramesh A, Srikumari Srisailapathy CR, Scott DA, et al. (1997) New gene for autosomal recessive non-syndromic hearing loss maps to either chromosome 3q or 19p. Am J Med Genet 1997;71:467-71.
32. Rahi JS, Sripathi S, Gilbert CE, Foster A. Childhood blindness in lndia:causes in 1318 blind school students in nine states. Eye 1995;9:545-50.
33. Kumaramanickavel G, Joseph B, Vidhya A, Arokiasamy T, Sridhara Shetty N. Consanguinity and ocular genetic disease in South India:analysis of a five-year study. Commun Genet 2002;5:182-5.
34. Panicker SG, Reddy ABM, Mandal AK, Ahmed N, Nagarajaram HA, et al. Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. Invest Ophthal Vis Sci 2002;43:1358-66.
35. Hornby SJ, Dandona L, Foster A, Jones RB, Gilbert CE. Clinical findings, consanguinity and pedigrees in children with anonphtalmos in southern India. Dev Med Child Neurol 2001;43:392-8.
36. Agrawal N, Sinha SN, Jensen AR. Effects of inbreeding on Raven matrices. Behav Genet 1984;14:579-585.
37. Afzal M. Consequences of consanguinity on cognitive behavior. Behav Genet 1988;18:583-94.
38. Sinclair S. Familial mental retardation and parental consanguinity. Ind J Med Res 1972;60:1718-23.
39. Madhavan T, Narayan J. Consanguinity and mental retardation. J Mental Defic Res 1991;35:133-9.
40. Pitchappan RM. Castes, migration, immunogenetics and infectious diseases in South India. Commun Genet 2002;5:157-61.
41. Mohanty D, Colah RB, Gorakshakar AC, Nadkarni AH, Phanasgaonkar SP, Shetty S, Ghosh K, Mukherjee MB. Genetic disorders in haematological practice in India. Commun Genet 2002;5:197-200.
42. Appaji Rao N, Radha Rama Devi A, Savithri HS, Venkat Rao S, Bittles AH. Neonatal screening for amino acidaemias in Karnataka, South India. Clin Genet 1988;34:60-3.
43. Ramadevi R, Savithri HS, Radha Rama Devi A, Bittles AH, Appaji Rao N. An unusual distribution of glucose 6-phosphate dehydrogenase deficiency from the South Indian population. Ind J Biochem Biophys 1994:31:358-60.
44. Radha Rama A, Appaji Rao N, Bittles AH. Consanguinity and the incidence of childhood genetic disease in Karnataka, South India. J Med Genet 1987;24:362-5.
45. Christopher R, Nalini A. Cerebral lipidoses in patients with progressive neurodegeneration: a study from South India. Commun Genet 2002;5:186-91.
46. Bittles AH, Savithri HS, Appaji Rao N. Community genetics in developing countries. Commun Genet 2002;5:151-2.
47. Bittles AH. Consanguinity and its relevance to clinical genetics. Clin Genet 2001;60:89-98.
48. Appaji Rao N. Genetic consequences of inbreeding in a large human population. Proc Ind Natl Sci Acad 1991;B57:361-8.
49. Sandford-Smith J. Childhood blindness in India. Eye 1995;9:v-vi.
50. Ahmed S, Saleem M, Modell B, Petrou M. Screening extended families for genetic hemoglobin disorders in Pakistan. New Engl J Med 2002;347:1162-8.
51. Savithri HS, Venkatesha Murthy HS, Baskaran G, Appaji Rao N, Kool D, Edkins E, et al. Predictive testing for familial adenomatous polyposis in a rural South Indian community. Clin Genet 2000:58:57-60.
52. Verma IC, Bijarnia S. The burden of genetic disorders in India and a framework for community control. Commun Genet 2002;5:192-196.