Investigating the genetic instability in the peripheral lymphocytes of 36 untreated lung cancer patients with comet assay and micronucleus assay

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 617, Issue 1-2, 2007, Pages 104-110

  Lou, Jianlin ^a   He, Jiliang ^a,b   Zheng, Wei ^a   Jin, Lifen ^a   Chen, Zhijian ^a   Chen, Shijie ^a   Lin, Yongxing ^a   Xu, Shijie ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b JIAXING UNIVERSITY   (China)

Author keywords

Comet assay; Genetic instability; Lung cancer; Micronucleus assay

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC DAMAGE; GENOMIC INSTABILITY; HUMAN; IONIZING RADIATION; LUNG CANCER; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ADULT; AGED; CASE-CONTROL STUDIES; CELLS, CULTURED; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; FEMALE; HUMANS; INFRARED RAYS; LUNG; LUNG NEOPLASMS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED;

EID: 33847698160     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.01.004     Document Type: Article

References (16)

1. Jefford C.E., and Irminger-Finger I. Mechanisms of chromosome instability in cancers. Crit. Rev. Oncol. Hematol. 59 (2006) 1-14
2. Gollin S.M. Chromosomal instability. Curr. Opin. Oncol. 16 (2004) 25-31
3. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
4. Kassie F., Parzefall W., and Knasmuller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutat. Res. 463 (2000) 13-31
5. Jianlin L., Jiliang H., Lifen J., Wei Z., Baohong W., and Hongping D. Measuring the genetic damage in cancer patients during radiotherapy with three genetic end-points. Mutagenesis 19 (2004) 457-464
6. Wei Q., Wang L.E., Sturgis E.M., and Mao L. Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 1961-1966
7. Fenech M., and Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147 (1985) 29-36
8. Albertini R.J., Anderson D., Douglas G.R., Hagmar L., Hemminki K., Merlo F., Natarajan A.T., Norppa H., Shuker D.E., Tice R., Waters M.D., and Aitio A. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutat. Res. 463 (2000) 111-172
9. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
10. Chang J.W., Chen Y.C., Chen C.Y., Chen J.T., Chen S.K., and Wang Y.C. Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer. Clin. Cancer Res. 6 (2000) 1639-1646
11. Ninomiya H., Nomura K., Satoh Y., Okumura S., Nakagawa K., Fujiwara M., Tsuchiya E., and Ishikawa Y. Genetic instability in lung cancer: concurrent analysis of chromosomal, mini- and microsatellite instability and loss of heterozygosity. Br. J. Cancer 94 (2006) 1485-1491
12. Masuda A., and Takahashi T. Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis. Oncogene 21 (2002) 6884-6897
13. Schabath M.B., Spitz M.R., Grossman H.B., Zhang K., Dinney C.P., Zheng P.J., and Wu X. Genetic instability in bladder cancer assessed by the comet assay. J. Natl. Cancer Inst. 95 (2003) 540-547
14. Bernstein C., Bernstein H., Payne C.M., and Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 511 (2002) 145-178
15. Friedberg E.C. How nucleotide excision repair protects against cancer. Nat. Rev. Cancer 1 (2001) 22-33
16. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374