Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements

Gene

Volumn 391, Issue 1-2, 2007, Pages 76-79

  Kantidze, Omar L ^a   Razin, Sergey V ^a  

^a INSTITUTE OF GENE BIOLOGY   (Russian Federation)

Author keywords

AML1 RUNX1 gene; Breakpoint cluster region; Chromosomal translocations; Etoposide

Indexed keywords

DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

AML1 GENE; ARTICLE; CANCER CHEMOTHERAPY; CELL CULTURE; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA REPAIR; ENZYME INHIBITION; GENE; GENETIC ASSOCIATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA TOPOISOMERASES, TYPE II; DRUG THERAPY; ETOPOSIDE; HUMANS; JURKAT CELLS; LEUKEMIA; NEOPLASMS; PROTEIN BINDING; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC;

EID: 33847690667     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2006.12.006     Document Type: Article

References (23)

1. Adachi N., Suzuki H., Iiizumi S., and Koyama H. Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193, implications for the repair of topoisomerase II-mediated DNA damage. J. Biol. Chem. 278 (2003) 35897-35902
2. Adachi N., Iiizumi S., So S., and Koyama H. Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA. Biochem. Biophys. Res. Commun. 318 (2004) 856-861
3. Aplan P.D., Chervinsky D.S., Stanulla M., and Burhans W.C. Sitespecific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 87 (1996) 2649-2658
4. Bae Y.S., Kawasaki I., Ikeda H., and Liu L.F. Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 2076-2080
5. Calsou P., Frit P., Humbert O., Muller C., Chen D.J., and Salles B. The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA. J. Biol. Chem. 274 (1999) 7848-7856
6. Chen S., et al. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: effect of Ku on repair fidelity. J. Biol. Chem. 276 (2001) 24323-24330
7. Cockerill P.N., and Garrard W.T. Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 44 (1986) 273-282
8. Das P.M., Ramachandran K., van Wert J., and Singal R. Chromatin immunoprecipitation assay. Biotechniques 37 (2004) 961-969
9. Felix C.A. Secondary leukemias induced by topoisomerase-targeted drugs. Biochim. Biophys. Acta 1400 (1998) 233-255
10. Iarovaia O.V., Shkumatov P., and Razin S.V. Breakpoint cluster regions of the AML-1 and ETO genes contain MAR elements and are preferentially associated with the nuclear matrix in proliferating HEL cells. J. Cell Sci. 117 (2004) 4583-4590
11. Iarovaia O.V., Akopov S.B., Nikolaev L.G., Sverdlov E.D., and Razin S.V. Induction of transcription within chromosomal DNA loops flanked by MAR elements causes an association of loop DNA with the nuclear matrix. Nucleic Acids Res. 33 (2005) 4157-4163
12. Kantidze O.L., Iarovaia O.V., and Razin S.V. Assembly of nuclear matrix-bound protein complexes involved in non-homologous end joining is induced by inhibition of DNA topoisomerase II. J. Cell. Physiol. 207 (2006) 660-667
13. Kegel A., Martinez P., Carter S.D., and Astrom S.U. Genome wide distribution of illegitimate recombination events in Kluyveromyces lactis. Nucleic Acids Res. 34 (2006) 1633-1645
14. Klochkov D., et al. A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain. Mol. Cell. Biol. 26 (2006) 1589-1597
15. Malik M., Nitiss K.C., Enriquez-Rios V., and Nitiss J.L. Roles of non-homologous end joining pathways in surviving topoisomerase II-mediated DNA damage. Mol. Cancer Ther. 5 (2006) 1405-1414
16. Park M.S., Ludwig D.L., Stigger E., and Lee S.H. Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells. J. Biol. Chem. 271 (1996) 18996-19000
17. Parsons C.A., Baumann P., Van Dyck E., and West S.C. Precise binding of single-stranded DNA termini by human RAD52 protein. EMBO J. 19 (2000) 4175-4181
18. Ratain M.J., and Rowley J.D. Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes. Ann. Oncol. 3 (1992) 107-111
19. Razin S.V. Chromosomal DNA loops may constitute basic units of the eukaryotic genome organization and evolution. Crit. Rev. Eukaryot. Gene Expr. 9 (1999) 279-283
20. Sperry A.O., Blasquez V.C., and Garrard W.T. Dysfunction of chromosomal loop attachment sites, illegitimate recombination linked to matrix association regions and topoisomerase II. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 5497-5501
21. Super H.J., et al. Rearrangements of MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 82 (1993) 3705-3711
22. Van Dyck E., Stasiak A.Z., Stasiak A., and West S.C. Binding of double-strand breaks in DNA by human Rad52 protein. Nature 398 (1999) 728-731
23. Zhang Y., Strissel P., and Strick R. Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3070-3075