In vitro activity of perifosine: A novel alkylphospholipid against the promastigote stage of Leishmania species

Parasitology Research

Volumn 100, Issue 5, 2007, Pages 1155-1157

  Cabrera Serra, María Gabriela ^a   Lorenzo Morales, Jacob ^a   Romero, Marialina ^a   Valladares, Basilio ^a   Piñero, José E ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EDELFOSINE; MILTEFOSINE; PERIFOSINE; PHOSPHOLIPID DERIVATIVE;

ARTICLE; DRUG ACTIVITY; IN VITRO STUDY; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA; PHOSPHORYLCHOLINE;

EID: 33847685204     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-006-0408-4     Document Type: Article

References (5)

1. Croft SL, Barrett MP, Urbina JA (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol 21:508-512
2. Escobar P, Matu S, Marques C, Croft SL (2002) Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH (3) (edelfosine) and amphotericin B. Acta Trop 81:151-157
3. Knowling M, Blackstein M, Tozer R, Bramwell V, Dancey J, Dore N, Matthews S, Eisenhauer EA (2006) Phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: a National Cancer Institute of Canada Clinical Trials Group trial. Invest New Drugs 24:435-439
4. Piñero J, Temporal RM, Silva-Goncalves AJ, Jimenez IA, Bazzocchi IL, Oliva A, Perera A, Leon LL, Valladares B (2006) New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis. Acta Trop 98:59-65
5. Santa-Rita RM, Henriques-Pons A, Barbosa HS, de Castro SL (2004) Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis. J Antimicrob Chemother 54:704-710