Fracture risk in patients treated with amiodarone or digoxin for cardiac arrhythmias: A nation-wide case-control study

Osteoporosis International

Volumn 18, Issue 4, 2007, Pages 409-417

  Rejnmark, L ^a   Vestergaard, P ^a   Mosekilde, L ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Amiodarone; Arrhythmia; Atrial fibrillation; Digoxin; Fracture; Osteoporosis

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; ANTIHYPERTENSIVE AGENT; ANTITHYROID AGENT; ANTIVITAMIN K; ANXIOLYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTEROID; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; FLECAINIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEVOTHYROXINE; LOOP DIURETIC AGENT; NEUROLEPTIC AGENT; NICORANDIL; POTASSIUM SPARING DIURETIC AGENT; PROPAFENONE; QUINIDINE; RALOXIFENE; SEDATIVE AGENT; SOTALOL; THIAZIDE DIURETIC AGENT; THYROID HORMONE;

ADULT; AGE DISTRIBUTION; ARTICLE; COMPUTER SYSTEM; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FOREARM FRACTURE; FRACTURE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGISTER; RISK REDUCTION; SEX RATIO; SPINE FRACTURE; TACHYCARDIA;

ADULT; AGE FACTORS; AGED; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOREARM INJURIES; FRACTURES, BONE; HIP FRACTURES; HUMANS; MALE; OSTEOPOROSIS; RISK FACTORS; SEX FACTORS; TACHYCARDIA;

EID: 33847680026     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0250-7     Document Type: Article

References (35)

1. Van Gelder IC, Hagens VE, Bosker HA et al (2002) A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation. N Engl J Med 347:1834-1840
2. Benjamin EJ, Wolf PA, D'Agostino RB et al (1998) Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 98:946-952
3. Stollberger C, Winkler-Dworak M, Finsterer J et al (2005) Factors influencing mortality in atrial fibrillation. Post hoc analysis of an observational study in outpatients. Int J Cardiol 103:140-144
4. Wandell PE (2001) Five-year mortality in men and women with atrial fibrillation. Scand J Prim Health Care 19:112-116
5. Patel PJ, Keating RJ, Gersh BJ et al (2004) Outcome of patients with newly diagnosed atrial fibrillation at the Mayo Clinic and residing in that area. Am J Cardiol 94:1379-1382
6. Staa TP, Leufkens HGM, Cooper C (2002) Utility of medical and drug history in fracture risk prediction among men and women. Bone 31:508-514
7. Frank L (2000) Epidemiology. When an entire country is a cohort. Science 287:2398-2399
8. Andersen TF, Madsen M, Jorgensen J et al (1999) The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46:263-268
9. Vestergaard P, Mosekilde L (2002) Fracture risk in patients with celiac Disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in Denmark. Am J Epidemiol 156:1-10
10. Wacholder S, McLaughlin JK, Silverman DT et al (1992) Selection of controls in case-control studies. I. Principles. Am J Epidemiol 135:1019-1028
11. Nielsen GL, Sorensen HT, Zhou W et al (1997) The pharmacoepidemiologic prescription database of North Jutland - a valid tool in pharmacoepidemiological research. Int J Risk Safety Med 10:203-205
12. Capella D (1993) Descriptive tools and analysis. In: Dukes MNG (ed) Drug utilization studies: methods and uses. WHO Regional Publications, Copenhagen, pp 55-58
13. Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373-383
14. de Groot V, Beckerman H, Lankhorst GJ et al (2003) How to measure comorbidity. a critical review of available methods. J Clin Epidemiol 56:221-229
15. Miettinen OS (1985) Theoretical epidemiology: principles of occurrence research in medicine. John Wiley & Sons, New York
16. Chatap G, Giraud K, Vincent JP (2002) Atrial fibrillation in the elderly: facts and management. Drugs Aging 19:819-846
17. Rho RW, Page RL (2005) Asymptomatic atrial fibrillation. Progr Cardiovasc Dis 48:79-87
18. Lawlor DA, Patel R, Ebrahim S (2003) Association between falls in elderly women and chronic diseases and drug use: cross sectional study. Br Med J 327:712-717
19. Basaria S, Cooper DS (2005) Amiodarone and the thyroid. Am J Med 118:706-714
20. Vestergaard P, Rejnmark L, Mosekilde L (2005) Influence of hyper- and hypothyroidism, and the effects of treatment with antithyroid drugs and levothyroxine on fracture risk. Calcif Tissue Int 77:139-144
21. Strasburger JF, Cuneo BF, Michon MM et al (2004) Amiodarone therapy for drug-refractory fetal tachycardia. Circulation 109:375-379
22. Shukla R, Jowett NI, Thompson DR et al (1994) Side effects with amiodarone therapy. Postgrad Med J 70:492-498
23. Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S-1688S
24. Stein MS, Wark JD, Scherer SC et al (1999) Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel. J Am Geriatr Soc 47:1195-1201
25. Mosekilde L (2005) Vitamin D and the elderly. Clin Endocrinol 62:265-281
26. Johnell O, Gullberg B, Kanis JA et al (1995) Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res 10:1802-1815
27. Zittermann A, Schleithoff SS, Tenderich G et al (2003) Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 41:105-112
28. Scragg R, Jackson R, Holdaway IM et al (1990) Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol 19:559-563
29. Rostand SG (1997) Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension 30:150-156
30. Koski K, Luukinen H, Laippala P et al (1996) Physiological factors and medications as predictors of injurious falls by elderly people: a prospective population-based study. Age Ageing 25:29-38
31. Taggart HM (1988) Do drugs affect the risk of hip fracture in elderly women? J Am Geriatr Soc 36:1006-1010
32. Liberman D, Brami JL, Bark H et al (1991) Effect of digoxin on respiratory muscle performance in patients with COPD. Respiration 58:29-32
33. Siafakas NM, Stathopoulou M, Tzanakis N et al (2000) Effect of digoxin on global respiratory muscle strength after cholecystectomy: a double blind study. Thorax 55:497-501
34. Baron R, Neff L, Roy C et al (1986) Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell 46:311-320
35. Hoidrup S, Gronbaek M, Gottschau A et al (1999) Alcohol intake, beverage preference, and risk of hip fracture in men and women. Copenhagen Centre for Prospective Population Studies. Am J Epidemiol 149:993-1001