Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 1, 2007, Pages 154-160

  Ijäs, Petra ^a,b,g   Nuotio, Krista ^a,b   Saksi, Jani ^b   Soinne, Lauri ^a   Saimanen, Eija ^a,c   Karjalainen Lindsberg, Marja Liisa ^a   Salonen, Oili ^a   Sarna, Seppo ^d   Tuimala, Jarno ^e   Kovanen, Petri T ^f   Kaste, Markku ^a   Lindsberg, Perttu J ^a,b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b BIOMEDICUM HELSINKI   (Finland)

^c SOUTH KARELIA CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e IT Center for Science   (Finland)

^f WIHURI RESEARCH INSTITUTE   (Finland)

^g NONE   (Finland)

Author keywords

Atherosclerosis; Carotid arteries; Gene expression; Microarray; Stroke

Indexed keywords

CD163 ANTIGEN; HEME OXYGENASE 1; IRON; MESSENGER RNA; TRANSFERRIN RECEPTOR; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; DNA; HEME; HMOX1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; BRAIN ATHEROSCLEROSIS; CAROTID ARTERY OBSTRUCTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; GENE INDUCTION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; BLEEDING; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CAROTID STENOSIS; DNA; FEMALE; GENE EXPRESSION REGULATION; HEME; HEME OXYGENASE-1; HEMORRHAGE; HUMANS; IRON; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CELL SURFACE; RECEPTORS, TRANSFERRIN; RNA, MESSENGER;

EID: 33847670874     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000251991.64617.e7     Document Type: Article

References (27)

1. Kappelle LJ. Symptomatic carotid artery stenosis. J Neurol. 2002;249:254-259.
2. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med. 1991;325:445-453.
3. Golledge J, Greenhalgh RM, Davies AH. The symptomatic carotid plaque. Stroke. 2000;3:774-781.
4. Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, Tran N, Polissar NL, Isaac C, Ferguson MS, Garden GA, Cramer SC, Maravilla KR, Hashimoto B, Hatsukami TS. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI-initial results. Stroke. 2006;37:818-823.
5. Martinet W, Schrijvers DM, De Meyer GRY, Thielemans J, Knaapen MWM, Herman AG, Kockx MM. Gene Expression profiling of apoptosis-related genes in human atherosclerosis: upregulation of death-associated protein kinase. Arterioscler Thromb Vasc Biol. 2002;22:2023-2029.
6. McCaffrey TA, Fu C, Du B, Eksinar S, Kent KC, Bush H, Jr., Kreiger K, Rosengart T, Cybulsky MI, Silverman ES, Collins T. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest. 2000;105:653-662.
7. Faber BCG, Cleutjens KBJM, Niessen RLJ, Aarts PLJW, Boon W, Greenberg AS, Kitslaar PJEHM, Tordoir JHM, Daemen MJAP. Identification of genes potentially involved in rupture of human atherosclerotic plaques. Circ Res. 2001;89:547-554.
8. Vemuganti R, Dempsey RJ. Carotid atherosclerotic plaques from symptomatic stroke patients share the molecular fingerprints to develop in a neoplastic fashion: A microarray analysis study. Neuroscience. 2005;131:359-374.
9. Papaspyridonos M, Smith A, Burnand KG, Taylor P, Padayachee S, Suckling KE, James CH, Greaves DR, Patel L. Novel Candidate Genes in unstable areas of human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2006;26:1837-1844.
10. Inzitari D, Eliasziw M, Gates P, Sharpe BL, Chan RKT, Meldrum HE, Barnett HJM, The North Am Symptomatic Carotid Endarterectomy Trial Collaborators. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. N Engl J Med. 2000;342:1693-1701.
11. Nuotio K, Lindsberg PJ, Carpen O, Soinne L, Lehtonen-Smeds EMP, Saimanen E, Lassila R, Sairanen T, Sarna S, Salonen O, Kovanen PT, Kaste M. Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis. Neurology. 2003;60:1890-1899.
12. Lehtonen-Smeds EMP, Mäyränpää M, Lindsberg PJ, Soinne L, Saimanen E, Järvinen AAJ, Salonen O, Carpen O, Lassila R, Sarna S, Kaste M, Kovanen PT. Carotid plaque mast cells associate with atherogenic serum lipids, high grade carotid stenosis and symptomatic carotid artery disease. Cerebrovasc Dis. 2005;19:291-301.
13. Soinne L, Saimanen E, Malmberg-Céder K, Kovanen P, Lindsberg PJ, Kaste M, Lassila R. Association of the fibrinolytic system and hemorheology with symptoms in patients with carotid occlusive disease. Cerebrovasc Dis. 2005;20:172-179.
14. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W, Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, Am Heart Association. Circulation. 1995;92:1355-1374.
15. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001;29:365-371.
16. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5:R80.
17. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249-264.
18. Dennis G, Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003;4:P3.
19. Haile DJ. Regulation of genes of iron metabolism by the iron-response proteins. Am J Med Sci. 1999;318:230-240.
20. Shi W, Haberland ME, Jien ML, Shih DM, Lusis AJ. Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation. 2000;102:75-81.
21. Gordon S. Alternative activation of macrophages. Nature Rev Immunol. 2003;3:23-35.
22. Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, Farb A, Guerrero LJ, Hayase M, Kutys R, Narula J, Finn AV, Virmani R. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med. 2003;349:2316-2325.
23. Kockx MM, Cromheeke KM, Knaapen MW, Bosmans JM, De Meyer GR, Herman AG, Bult H. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:440-446.
24. Siow RC, Sato H, Mann GE. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res. 1999;41:385-394.
25. Duckers HJ, Boehm M, True AL, Yet SF, San H, Park JL, Clinton Webb R, Lee ME, Nabel GJ, Nabel EG. Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med. 2001;7:693-698.
26. Schaer DJ. The macrophage hemoglobin scavenger receptor (CD163) as a genetically determined disease modifying pathway in atherosclerosis. Atherosclerosis. 2002;163:199-201.
27. Ameriso SF, Villamil AR, Zedda C, Parodi JC, Garrido S, Sarchi MI, Schultz M, Boczkowski J, Sevlever GE. Heme oxygenase-1 is expressed in carotid atherosclerotic plaques infected by Helicobacter pylori and is more prevalent in asymptomatic subjects. Stroke. 2005;36:1896-1900.