On the role of ex post uncertainty assessment for risk management

International Journal of Risk Assessment and Management

Volumn 5, Issue 2-4, 2005, Pages 206-215

  Heinzl, Harald ^a   Mittlboeck, Martina ^a   Edler, Lutz ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

cancer; Carrier kinetic; computer simulation study; dioxin; environmentally hazardous compound; risk assessment; uncertainty assessment

Indexed keywords

EID: 33847670522     PISSN: 14668297     EISSN: 17415241     Source Type: Journal    
DOI: 10.1504/ijram.2005.007168     Document Type: Article

References (16)

1. Becher, H., Flesch-Janys, D., Gurn, P. and Steindorf, K. (1998) Krebsrisikoabschätzung für Dioxine [Quantitative Cancer Risk Assessment for Dioxins], Berlin: Erich Schmidt Verlag.
2. Bois, F.Y. and Diack, C.T. (2005) ‘Uncertainty analysis: the Bayesian approach’, in L. Edler and C.P. Kitsos (Eds) Quantitative Methods for Cancer and Human Health Risk Assessment, Chichester: Wiley.
3. Carrier, G., Brunet, R.C. and Brodeur, J. (1995a) ‘Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues’, Toxicology and Applied Pharmacology, Vol. 131, pp.253–266.
4. Carrier, G., Brunet, R.C. and Brodeur, J. (1995b) ‘Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. II. Kinetics of absorption and disposition of PCDD/PCDFs’, Toxicology and Applied Pharmacology, Vol. 131, pp.267–276.
5. Cox, D.R. (1972) ‘Regression models and life tables (with discussion)’, Journal of the Royal Statistical Society B, Vol. 34, pp.187–220.
6. Edler, L., Heinzl, H. and Mittlboeck, M. (2004) ‘Carrying-over toxicokinetic model uncertainty into cancer risk estimates: the TCDD example’, Organohalogen Compounds, Vol. 66, pp.3356–3362.
7. Flesch-Janys, D., Berger, J., Gurn, P., Manz, A., Nagel, S., Waltsgott, H. and Dwyer, J.H. (1995) ‘Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany’, American Journal of Epidemiology, Vol. 142, pp.1165–1175. Published erratum appears in American Journal of Epidemiology, Vol. 144, p.716 (1996).
8. Geusau, A., Schmaldienst, S., Derfler, K., Päpke, O. and Abraham, K. (2002) ‘Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients’, Arch Toxicol, Vol. 76, pp.316–325.
9. Heinzl, H. and Edler, L. (2002) ‘Assessing uncertainty in a toxicokinetic model for human lifetime exposure to TCDD’, Organohalogen Compounds, Vol. 59, pp.355–358.
10. Heinzl, H. and Edler, L. (2003) ‘Evaluating and assessing uncertainty of large-scaled statistical analyses exemplified at the Boehringer TCDD cohort’, RM 2003, Proceedings of the Second Workshop on Research Methodology, Amsterdam: VU University, pp.87–94.
11. Heinzl, H. and Mittlboeck, M. (2004) ‘Design aspects of a computer simulation study for assessing uncertainty in human lifetime toxicokinetic models’, Compstat 2004, Proceedings in Computational Statistics, Heidelberg: Physica-Verlag, pp.199–211.
12. IARC (1997) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 69, Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans, Lyon: International Agency for Research on Cancer.
13. McGregor, D.B., Partensky, C., Wilbourn, J. and Rice, J.M. (1998) ‘An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis’, Environ Health Perspect, Vol. 106, Suppl. 2, pp.755–760.
14. Michalek, J.E., Pirkle, J.L., Needham, L.L., Patterson Jr., D.G., Caudill, S.P., Tripathi, R.C. and Mocarelli, P. (2002) ‘Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation ranch hand’, Journal of Exposure Analysis and Environmental Epidemiology, Vol. 12, pp.44–53.
15. Thomaseth, K. and Salvan, A. (1998) ‘Estimation of occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin using a minimal physiologic toxicokinetic model’, Environmental Health Perspectives, Vol. 106, Suppl. 2, pp.743–753. Published erratum appears in Environmental Health Perspectives, Vol. 106, Suppl. 4, p.CP2.
16. Vose, D. (2000) Risk Analysis: A Quantitative Guide, 2nd edn, Chichester: Wiley.