Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2667-2679

  Kim, Ha Young ^a   Kuhn, Richard J ^b   Patkar, Chinmay ^b   Warrier, Ranjit ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Alphaviruses; Antiviral; Dioxane; Sindbis virus; Synthesis

Indexed keywords

1 (1,4 DIOXAN 2 YL)ETHAN 1 OL; 1,3 BIS(1,4 DIOXAN 2 YL) 2 (1,3 DITHIAN 2 YL)PROPANE; 1,3 BIS(1,4 DIOXAN 2 YL) 2 (METHYLOXIMINO)PROPANE; 1,3 BIS(1,4 DIOXAN 2 YL) 2 OXIMINOPROPANE; 1,3 BIS(1,4 DIOXAN 2 YL) 2 PROPANONE; 1,3 BIS(1,4 DIOXAN 2 YL)PROPAN 2 OL; 1,3 BIS(1,4 DIOXAN 2 YL)PROPANE; 1,4 BIS(1,4 DIOXAN 2 YL) 2 (1,3 DITHIAN 2 YL)BUTANE; 1,4 BIS(1,4 DIOXAN 2 YL) 2 BUTANONE; 1,4 BIS(1,4 DIOXAN 2 YL)BUTAN 2 OL; 1,4 BIS(1,4 DIOXAN 2 YL)BUTANE; 1,4 DIOXAN 2 YLACETALDEHYDE; 1,4 DIOXANE DERIVATIVE; 1,5 BIS(1,4 DIOXAN 2 YL)PENTAN 2 ONE; 1,5 BIS(1,4 DIOXAN 2 YL)PENTANE; 2 (1,3 DITHIANYLMETHYL) 1,4 DIOXANE; 2 (1,4 DIOXAN 2 YL)ETHANOL; 2 (2 IODOETHYL) 1,4 DIOXANE; 2 (4 PHENYLBUTYL) 1,4 DIOXANE; 2 [2 (1,3 DITHIAN 2 YL)ETHYL] 1,4 DIOXANE; 2 HYDROXYMETHYL 1,4 DIOXANE; 3 (1,4 DIOXAN 2 YL)PROPAN 1 OL; 3 (2 CHLOROETHOXY) 1,2 EPOXYPROPANE; ANTIVIRUS AGENT; CAPSID PROTEIN; CHLORPROMAZINE; DIOXANE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN BHK; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HYDROPHOBICITY; NONHUMAN; PROTEIN STRUCTURE; SINDBIS VIRUS; STEREOCHEMISTRY; STEREOSPECIFICITY; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CAPSID PROTEINS; CELL LINE; CELL SURVIVAL; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DIOXANES; GLYCOPROTEINS; INDICATORS AND REAGENTS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SINDBIS VIRUS; VIRUS REPLICATION;

MIRIDAE; SINDBIS VIRUS;

EID: 33847668907     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.040     Document Type: Article

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