Ethical and regulatory issues surrounding African traditional medicine in the context of HIV/AIDS

Developing World Bioethics

Volumn 7, Issue 1, 2007, Pages 25-34

  Nyika, Aceme ^a,b,c  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

African traditional medicine; Ethics; HIV AIDS; Regulations

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICA; BIODIVERSITY; BIOETHICS; HEALTH CARE ORGANIZATION; HEALTH CARE SYSTEM; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; REVIEW; STANDARD; TRADITIONAL MEDICINE; WELFARE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AFRICA SOUTH OF THE SAHARA; BIOMEDICAL RESEARCH; DEVELOPING COUNTRIES; ETHICS; HIV INFECTIONS; HUMANS; MEDICINE, AFRICAN TRADITIONAL; PHYTOTHERAPY;

EID: 33847667202     PISSN: 14718731     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-8847.2006.00157.x     Document Type: Review

References (106)

1. The Nuremberg Code. 1949. Trials of War Criminals Before the Nuremberg Military Tribunals Under Control Council Law. Nuremberg, October 1946-April 1949. Washington, DC: US Government Printing Office: No.1; Vol.2: 181-182.
2. World Health Organization (WHO). 2003. Traditional Medicine. Geneva: WHO. Fact Sheet 134. Available at: http://www.who.int/ mediacentre/factsheets/2003/fs134/en/ [Accessed 5 June 2006].
3. Ibid.
4. M. Cohen. 2003. Aristotle's Metaphysics. Stanford, CA: Stanford Encyclopaedia of Philosophy. Available at: http://plato.stanford.edu/entries/ aristotle-metaphysics/ [Accessed 5 June 2006].
5. A. Kleinman, L. Eisenberg & B. Good. Culture, Illness and Care: Clinical Lessons in Anthropology and Cross-cultural Research. Ann Intern Med 1978; 88: 251-258.
6. K. Little. 1954. The Mende in Sierra Leone. In African Worlds. Studies in the Cosmological Ideas and Social Values of African Peoples. D. Forde, ed. London: Oxford University Press: 127-128.
7. The Mystica. 2006. Necromancy. Online: The Mystica: An On-line Encyclopedia of the Occult, Mysticism, Magic, Paranormal and More. . . . Available at: http://www.themystica.com/mystica/articles/n/necromancy.html [Accessed 5 June 2006].
8. D. Klayman. Qinghaosu (Artemisinin): Antimalarial Drug from China. Science 1985; 238: 1049.
9. C. Ansah & N.J. Gooderham. The Popular Herbal Antimalarial, Extract of Cryptolepis sanguinolenta, is Potently Cytotoxic. Toxicol Sci 2002; 70: 245-251;
10. M. Willcox, G. Bodeker & P. Rasoanaivo. 2004. Traditional Medicinal Plants. Boca Raton: CRC Press.
11. K. Bonjean et al. The DNA-intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primary DNA Synthesis in B16 Melanoma Cells. Biochemistry 1998; 37: 5136-5146.
12. L. Dassonville et al. Cytotoxicity and Cell Cycle Effects of Plant Alkaloids Cryptolepine and Neocryptolepine: Relation to Druginduced Apoptosis. Eur J Pharmacol 2000; 409: 9-18.
13. Food and Agriculture Organization of the United Nations (FAO). Living Well with HIV/AIDS. Geneva: UN. Available at: ftp://ftp.fao.org/ docrep/fao/005/y4168E/y4168E00.pdf [Accessed 7 June 2006];
14. Health24.com. 2006. Beetroot, Garlic, Onions and Aids. Cape Town: Health24. Available at: http://www.health24.com/dietnfood/General/15-742-775, 30354.asp [Accessed 8 June 2006];
15. Herald. 2005. 900 People Undergo Herbal Therapy. The Herald (Zimbabwe) 5 September. Available at: http://www.zimbabwesituation.com/ sept7_2005.html [Accessed 8 June 2006];
16. Mail & Guardian Online. 2005. Bogus Aids Cures Flood Swaziland. Mail & Guardian Online 30 December. Available at: http:// www.mg.co.za/articledirect.aspx?articleid=39732&area= %2fbreaking_news%2fbreaking_news_africa%2f [Accessed 4 June 2006];
17. IRINNEWS. Org. 2005. ZIMBABWE: Traditional Healers Make a Killing as Healthcare Costs Rocket. Online: IRINNEWS.ORG. Available at: http:// www.irinnews.org/report.asp?ReportID=48781 [Accessed 4 June 2006].
18. A. Abdulbaqi (trans. I. Alayoubi). HIV Cure Gives Folk Medicine the Upper Hand. Doha: Islam Online. Available at: http://www.islamonline. net/English/science/2002/11/article07.shtml [Accessed 4 June 2006].
19. G. Bodeker et al. A Regional Taskforce on Traditional Medicine and AIDS. Lancet 2000; 355: 1284;
20. Guardian. 2000. Traditional Medicine Practice and Practitioners are Accorded Formal Status in the Nigerian National Health System, and will Contribute to the Fight against HIV/ AIDS. The Guardian (Nigeria) 6 December. Available at: http:// www.worldbank.org/afr/ik/guardart.htm [Accessed 4 June 2006];
21. Bioresources Development and Conservation Programme (BDCP). 2006. Drug Development: Science for the Common Good. Washington, DC: BDCP. Available at: http://www.bioresources.org/prog2.htm [Accessed 4 June 2006];
22. Abdulbaqi, op. cit. note 13.
23. Little, op. cit. note 6.
24. P. Geschiere & F. Cyprian. Domesticating Violence: Witchcraft, Courts and Confessions in Cameroon. Africa 1994; 64: 323-341;
25. Little, op. cit. note 6;
26. C.W. Ford. 2003. African Myth Search for the Sacred Within: Literal Enactment Deeply Misguided. Cape Times 15 October. Available at: http://www.capetimes.co.za/index.php?fSectionId=271&fArticleId=260964 [Accessed 4 June 2006];
27. Mail & Guardian Online. 2001. Zimbabwe Healer Moots Magic Chastity Potion. Mail & Guardian Online 10 October. Available at: http://www.mg.co.za/articledirect. aspx?articleid=227089&area= %2farchives_Online_edition%2f [Accessed 4 June 2006].
28. B.L. Meel. The Myth of Child Rape as a Cure for HIV/AIDS in Transkei: A Case Report. Med Sci Law 2003; 43: 85-88;
29. N.E. Groce & R. Trasi. Rape of Individuals with Disability: AIDS and the Folk Belief of Virgin Cleansing. Lancet 2004; 363: 1663-1664;
30. C. Smith. 2004. Rape has become a Way of Life in South Africa: Police Reported this Week that they were Achieving Success in Combating Most Crimes, but Not Rape. Durban: Health Systems Trust. Available at: http:// www.hst.org.za/news/20040511 [Accessed 5 June 2006];
31. G. du Venage. 2002. Rape of Children Surges in South Africa: Minors Account for About 40% of Attack Victims. San Francisco Chronicle 12 February. Available at: http://www.aegis.com/news/sc/2002/SC020203.html [Accessed 5 June 2006];
32. P. Govender. 1999. Child Rape: A Taboo within the AIDS Taboo; More and More Girls are being Raped by Men who Believe this will 'Cleanse' them of the Disease, but People don't want to Confront the Issue. Sunday Times (South Africa) 4 April. Available at: http://www.aegis.com/news/suntimes/1999/ ST990401.html?FACTNet [Accessed 5 June 2006];
33. The Body: The Complete HIV/AID Resource. 2003. Rise in Child Rapes in Zambia Traced to AIDS Cure Myth, Some Say. Menlo Park, CA: Henry J. Kaiser Family Foundation. Available at: http://www.thebody.com/Kaiser/2003/dec22_03/ child_rape.html?m29o [Accessed 5 June 2006].
34. AllAfrica.com. Ghanaians Killed for Rituals as Government Delegation Dumbfounded. Online: AllAfrica.com. Available at: http:// allafrica.com/stories/ 200508190871.html (Subscription) [Accessed 5 June 2006];
35. R. Mweninguwe. 2005. Ritual Murder Mars Women's Day. Nairobi: News From Africa. Available at: http://www.newsfromafrica. org/newsfromafrica/ articles/art_10175.html [Accessed 5 June 2006];
36. E. Barry. 2005. The Witchcraft Murder. Washington, DC: National Geographic. Available at: http://blogs.nationalgeographic.com/channel/blog/2005/ 03/explorer_witchcraft.html [Accessed 5 June 2006];
37. Daily News. 1999. Couple in Alleged Ritual Killing Granted Bail. The Daily News 30 March: 2;
38. Standard. 1991. Too Old to be Sacrificed. The Standard 18-24 April: 1;
39. Sunday Mail. 1999. Ritual Murders and Trade in Body Parts on the Increase. The Sunday Mail 18 April: 2.
40. United Nations (UN). 2002. United Nations Rights Expert Calls for Measures Aimed at Child Victims of Sexual Violence in South Africa. Press Release, 14 October. Geneva: UN. Available at: http://www. unhchr.ch/hurricane/ huricane.nsf/0/7EEF5A26FEC5AAF4C1256C 48003259EB?opendocument [Accessed 5 June 2006].
41. L.F. Prescott. Post-operative Bleeding Caused by Aspirin. J Dent 1980; 6: 207-208.
42. National Reye's Syndrome Foundation. Reye's Syndrome. Online: National Reye's Syndrome Foundation. Available at: http:// www.reyessyndrome. org/ [Accessed 5 June 2006].
43. AVERT.ORG. HIV & AIDS in Africa. The HIV & AIDS Epidemic in Africa. Horsham: Avert. Available at: http://www.avert.org/aidsinafrica. htm [Accessed 5 June 2006].
44. Ibid.
45. F.J. Palella et al. Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection. N Engl J Med 1998; 338: 853-860;
46. C. Kabugo et al. Long-term Experience Providing Antiretroviral Drugs in a Fee-for-service HIV Clinic in Uganda: Evidence of Extended Virologic and CD4+ Cell Count Responses. J Acquir Immune Defic Syndr 2005; 38: 578-583.
47. Food and Agriculture Organization of the United Nations, op. cit. note 12;
48. Health24.com, op. cit. note 12;
49. Mail & Guardian Online, op. cit. note 12;
50. IRINNEWS.Org, op. cit. note 12;
51. Abdulbaqi, op. cit. note 13.
52. Food and Agriculture Organization of the United Nations, op. cit. note 12;
53. Health24.com, op. cit. note 12.
54. News24.com. 2005. Manto Sticks to her Guns. Online: News24.com. Available at: http://www.news24.com/News24/South_Africa/Aids_Focus/0,6119,2-7- 659_1700396,00.html [Accessed 5 June 2006];
55. News24.com. 2005. Dr Garlic Defends Aids Work. Online: News24.com. Available at: http://www.news24.com/News24/South_Africa/Aids_Focus/0,,2-7- 659_1700492,00.html [Accessed 5 June 2006].
56. Herald, op. cit. note 12.
57. S. Tsiko. 2006. Launch of Traditional Medicine School a Milestone. The Herald (Zimbabwe) 8 May. Available at: http://allafrica.com/stories/ 200605090194.html [Accessed on 6 June 2006];
58. Herald. 2005. Moringa Oleifera Miracle Tree that Boosts Immune System. The Herald (Zimbabwe) 5 June.
59. Palella et al., op. cit. note 24;
60. Kabugo et al., op. cit. note 24.
61. F.M. Hecht et al. Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-transcriptase and Protease Inhibitors. N Engl J Med 1998; 339: 307-311;
62. D. Boden, A. Hurley & I. Zhang. HIV-1 Drug Resistance in Newly Infected Individuals. JAMA 1999; 282: 1135-1141;
63. S.J. Little, E.S. Daar & R.T. D'Aquila. Reduced Antiretroviral Drug Susceptibility among Patients with Primary HIV Infection. JAMA 1999; 282: 1142-1149;
64. S. Yerly et al. Transmission of Antiretroviral Drug-resistant HIV-1 Variants. Lancet 1999; 354: 729-733;
65. H.B. Gershengorn & S.M. Blower. The Impact of Antivirals and the Emergence of Drug Resistance: HSV-2 Epidemic Control. AIDS Patient Care STDs 2000; 14: 133-142.
66. M.A. Wainberg & G. Friedland. Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance [Special Communication]. JAMA 1998; 279: 1977-1983;
67. H. Salomon, M.A. Wainberg & B. Brenner. Prevalence of HIV 1 Resistant Antiretroviral Drugs in 81 Individuals Newly Infected by Sexual Contact or IDU. AIDS 2000; 14: F17-F23.
68. World Health Organization (WHO). Drug Resistance: HIV/AIDS. HIV Drug Resistance to Antiretroviral Drugs. Geneva: WHO. Available at: http://www.who.int/drugresistance/hivaids/en/ [Accessed 5 June 2006].
69. M. Merten & N. Deane. 2005. Vitriolic Dr Rath Attacks TAC. Mail & Guardian Online 15 March. Available at: http://www.mg.co.za/ articlePage.aspx?articleid=199867&area=/insight/insight_national/ [Accessed 5 June 2006];
70. L. Gedye. 2005. UN Condemns Raths HIVAids Advertisements. Mail & Guardian Online 4 April. Available at: http:// www.mg.co.za/articlePage. aspx?articleid=200811&area=/insight/monitor/ [Accessed 5 June 2006];
71. Mail & Guardian Online. 2005. Harvard Researchers Condemn Rath. Mail & Guardian Online 10 May. Available at: http://www.mg.co.za/ articlePage.aspx?articleid=237722&area=/breaking_news/ breaking_news_national/ [Accessed 5 June 2006].
72. J.B. Nachega et al. HIV/AIDS and Antiretroviral Treatment Knowledge, Attitudes, Beliefs, and Practices in HIV-infected Adults in Soweto, South Africa. Acquired Immune Defic Syndr 2005; 38: 196-201.
73. Food and Agriculture Organization of the United Nations, op. cit. note 12.
74. S.C. Piscitelli, A.H. Burstein & N. Welden. The Effect of Garlic Supplements on the Pharmacokinetics of Saquinavir. Clin Infec Dis 2002; 34: 234-238.
75. S.C. Piscitelli, A.H. Burstein & D. Chaitt. Indinavir Concentrations and St. John's Wort. Lancet 2000; 355: 547-548.
76. M.M. de Maat et al. Drug Interaction between St. John's Wort and Nevirapine. AIDS 2001; 15: 420-421.
77. A. Larpote. A New Decline in Preventive Behaviours among Homosexual Men: The Role of Highly Active Antiretroviral Therapy? Euro Surveill 2002; 7: 15-16;
78. International Collaboration on HIV Optimism. HIV Treatments Optimism among Gay Men: An International Perspective. J Acquir Immune Defic Syndr 2003; 33: 345-550;
79. J.M. Stephenson et al. Is Use of Antiretroviral Therapy among Homosexual Men Associated with Increased Risk of Transmission of HIV Infection? Sex Transm Infect 2003; 79: 7-10;
80. P. Van de Ven et al. HIV Treatment Optimism is Associated with Unprotected Anal Intercourse with Regular and Casual Partners among Australian Gay and Homosexually Active Men. Int J STD AIDS 2002; 13: 181-183;
81. J. Elford, G. Bolding & L. Sherr. High-risk Sexual Behaviour Increases among Gay Men between 1998 and 2001: What is the Role of HIV Optimism? AIDS 2002; 16: 1537-1544;
82. M.C. Boily et al. Changes in the Transmission Dynamics of the HIV Epidemic after the Wide-scale use of Antiretroviral Therapy could Explain Increases in Sexually Transmitted Infections: Results from Mathematical Models. Sex Transm Dis 2004; 31: 100-113.
83. World Health Organization (WHO). 2004. '3 by 5' Progress Report, December 2004. Geneva: WHO. Available at: http://www.who.int/3by5/ progressreport05/en/ [Accessed 5 June 2006].
84. Mail & Guardian Online, op. cit. note 12;
85. IRINNEWS.Org, op. cit. note 12.
86. CBC Archives. Thalidomide: Bitter Pills, Broken Promises. Toronto, ON: CBC. Available at: http://archives.cbc.ca/IDD-1-75-88/science_technology/ thalidomide/ [Accessed 5 June 2006].
87. BBC News. 2001. Nigerians Sue Pfizer over Test Deaths. London: BBC News. Available at: http://news.bbc.co.uk/1/hi/business/1517171.stm [Accessed 5 June 2006].
88. S. Mullholland. Virodene Saga a Lesson in how not to Conduct Affairs. Sunday Times. Business Times 30 August. Available at: http:// www.btimes.co.za/98/0329/columns/columns2.htm [Accessed 5 June 2006].
89. J.A. Singh & E.J. Mills. The Abandoned Trials of Pre-Exposure Prophylaxis for HIV: What Went Wrong? PLoS Med. 2005; 2: e234.
90. C.O. Adewunmi & A.O. Ojewole. Safety of Traditional Medicines, Complementary and Alternative Medicines in Africa. AJTCAM 2004; 1: 1-3.
91. B.E. van Wyk & M. Wink. 2004. Medicinal Plants of The World. Pretoria: Briza Publications: 164-167;
92. nd ed, London: Livingstone: 828-830.
93. C.F. Circosta et al. 1984. A Drug used in Traditional Medicine: Harpagophytum procumbens DC. II. Cardiovascular Activity. J Ethnopharmacol 11: 259-274.
94. I.M. Mahomed & A.O. Ojewole. Cardiovacscular Effects of Harpagophytum Procumbens [Pedaliaceae] Secondary Root Aqueous Extract in some Mammalian Experimental Animal Models. AJTCAM 2004; 1: 30-40.
95. E. Ngo Buma et al. Sedative and Anticonvulsant Properties of Passiflora Edulis Dried Leaves Decoction in Mice. AJTCAM 2004; 1: 63-71.
96. C. Wolfman et al. Possible Anxiolytic Effects of Chrysin, a Central Benzodiazepine Receptor Ligand Isolated from Passiflora coerulea. Pharmacol Biochem Behav 1994; 4: 1-4.
97. SAHealthInfo. 2006. Traditional Medicines. First Toxicity Study of Sutherlandia Leaf Powder (Sutherlandia microphylla) Consumption. Online: SAHealthInfo. Available at: http://www.sahealthinfo.org/traditionalmeds/ firststudy.htm [Accessed 5 June 2006].
98. US Food and Drug Administration (FDA). Evidence Report/Technology Assessment Number 76. Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects. Rockville, MD: FDA. Available at: http://www.fda.gov/bbs/topics/News/ephedra/summary.html [Accessed 5 June 2006].
99. US Food and Drug Administration (FDA). Sales of Supplements Containing Ephedrine Alkaloids (Ephedra) Prohibited. Rockville, MD: FDA. Available at: http://www.fda.gov/ov/initiatives/ephedra/december2003/ [Accessed 5 June 2006].
100. W.J. Griffin et al. Alkaloids of the Leaves of Erythrophleum Chlorostachys. Phytochem. 1971; 10: 2793-2797;
101. N.J. Loder et al. Tumor Inhibitory Plants: New Alkaloids from the Bark of Erythrophleum Chlorostachys (Leguminosaea). Aust J Chem 1974; 27: 179-185;
102. B.A. Adeoye & O.O. Oyedapo. Toxicity of Erythrophleum Guineense Stem-bark: Role of Alkaloidal Fraction. AJTCAM 2004; 1: 45-54.
103. World Health Organization, op. cit. note 2.
104. Ibid.
105. Ibid.
106. UNC Kenan-Flagler Business School. 2005. Corporate Responsibility in the Global Village. South Africa: Unilever Pays Bushmen to use Plant in Slim-Fast. Chapell Hill, NC: UNC Kenan-Flagler Business School. Available at: http://www.kenan-flagler.unc.edu/assets/documents/csr200501.pdf [Accessed 5 June 2006].