CW-270033, a novel pyrrolidinyl-thio carbapenem, has potent antimicrobial activity in vitro and in vivo

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 3, 2007, Pages 575-579

  Kim, Jongmyeung ^a   Ha, Jong Ryul ^b   Oh, Se Woong ^b   Kim, Hong Gi ^b   Lee, Jin Man ^c   Lee, Dong Gun ^a   Lee, Sang Han ^a   Kim, Jong Guk ^a  

^a Kyungpook National University   (South Korea)

^b Choongwae Pharma Co   (South Korea)

^c Kyongbuk College of Science   (South Korea)

Author keywords

Carbapenem; CW 270033; Dehydropeptidase I; Minimum inhibitory concentration (MIC); Protection test

Indexed keywords

CARBAPENEM DERIVATIVE; CW 270033; DEHYDROPEPTIDASE I; IMIPENEM; MEROPENEM; PEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIUM ISOLATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; ESCHERICHIA COLI; IN VITRO STUDY; IN VIVO STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CARBAPENEMS; CILASTATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; INJECTIONS, INTRAVENOUS; METHICILLIN RESISTANCE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PSEUDOMONAS AERUGINOSA; PYRROLIDINES; STAPHYLOCOCCUS AUREUS; THIENAMYCINS; VANCOMYCIN RESISTANCE;

EID: 33847656211     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.575     Document Type: Article

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