Odor processing in multiple chemical sensitivity

Human Brain Mapping

Volumn 28, Issue 3, 2007, Pages 172-182

  Hillert, Lena ^a,b   Musabasic, Vildana ^b   Berglund, Hans ^c   Ciumas, Carolina ^a   Savic, Ivanka ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM COUNTY COUNCIL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Environmental illness; Hypersensitivity; Odors; Positron emission tomography; Symptoms

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; BREATHING; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISTRESS SYNDROME; DOWN REGULATION; ELECTROCARDIOGRAM; ENVIRONMENTAL EXPOSURE; FEMALE; HEART RATE VARIABILITY; HUMAN; MULTIPLE CHEMICAL SENSITIVITY; ODOR; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RR INTERVAL; SENSITIZATION; SIGNAL PROCESSING;

ADULT; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; FEMALE; HEART RATE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MULTIPLE CHEMICAL SENSITIVITY; ODORS; OLFACTORY PATHWAYS; PERCEPTION; POSITRON-EMISSION TOMOGRAPHY; RESPIRATION;

EID: 33847414085     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/hbm.20266     Document Type: Article

References (45)

1. Anderson AK, Sobel N (2003): Dissociating intensity from valence as sensory inputs to emotion. Neuron 39:581-583.
2. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Watkins GL, Ponto LL, Hichwa RD (1995): PET studies of memory: novel vs. practiced free recall of word lists. Neuroimage 2:296-305.
3. Anonymous (1999): Multiple chemical sensitivity: a 1999 consensus. Arch Environ Health 54:147-149.
4. Bascom R, Meggs WJ, Frampton M, Hudnell K, Killburn K, Kobal G, Medinsky M (1997): Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation. Environ Health Perspect 105(Suppl 2):531-537.
5. Bell IR, Miller CS, Schwartz GE (1992): An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationships to kindling and affective spectrum disorders. Biol Psychiatry 32:218-242.
6. Bell IR, Hardin EE, Baldwin CM, Schwartz GE (1995): Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ Res 70:84-97.
7. Bell IR, Schwartz GE, Baldwin CM, Hardin EE (1996): Neural sensitization and physiological markers in multiple chemical sensitivity. Regul Toxicol Pharmacol 24(Pt 2):S39-S47.
8. Bengtsson S, Berglund H, Gulyas B, Cohen E, Savic I (2001): Brain activation during odor perception in males and females. Neuroreport 12:2027-2033.
9. Bush G, Luu P, Posner MI (2000): Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215-222.
10. Carlsson K, Petrovic P, Skare S, Petersson KM, Ingvar M (2000): Tickling expectations: neural processing in anticipation of a sensory stimulus. J Cogn Neurosci 12:691-703.
11. Critchley HD, Elliott R, Mathias CJ, Dolan RJ (2000): Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci 20:3033-3040.
12. Cullen M (1987): The worker with multiple chemical sensitivities: an overview. Occup Med 2:655-662.
13. Dalton P, Hummel T (2000): Chemosensory function and response in idiopathic environmental intolerance. Occup Med 15:539-556.
14. Devinsky O, Morrell MJ, Vogt BA (1995): Contributions of anterior cingulate cortex to behaviour. Brain 118(Pt 1):279-306.
15. Doty RL, Deems DA, Frye RE, Pelberg R, Shapiro A (1988): Olfactory sensitivity, nasal resistence, and autonomic function in patients with multiple chemical sensitivities. Arch Otorhinolaryngol Head Neck Surg 114:1422-1427.
16. Drevets WC, Burton H, Videen TO, Snyder AZ, Simpson JR Jr, Raichle ME (1995): Blood flow changes in human somatosensory cortex during anticipated stimulation. Nature 373:249-252.
17. Fink GR, Markowitsch HJ, Reinkemeier M, Bruckbauer T, Kessler J, Heiss WD (1996): Cerebral representation of one's own past: neural networks involved in autobiographical memory. J Neurosci 16:4275-4282.
18. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1991): Comparing functional (PET) images: the assesement of significant change. J Cereb Blood Flow Metab 11:690-699.
19. Friston KJ, Holmes AP, Worsley KJ (1999): How many subjects constitute a study? Neuroimage 10:1-5.
20. Jones-Gotman M, Zatorre RJ (1988): Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 7:111-120.
21. Kipen HM, Fiedler N (2002): Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge. Environ Health Perspect 110:597-599.
22. Kreutzer R, Neutra RR, Lashuay N (1999): Prevalence of people reporting sensitivities to chemicals in a population based study. Am J Epidemiol 150:1-12.
23. Levallois P, Neutra R, Lee G, Hristova L (2002): Study of self-reported hypersensitivity to electromagnetic fields in California. Environ Health Perspect 110(Suppl 4):619-623.
24. Lyskov E, Sandstrom M, Hansson Mild K (2001): Neurophysiological study of patients with perceived 'electrical hypersensitivity'. Int J Psychophysiol 42:233-241.
25. Maddock RJ, Garrett AS, Buonocore MH (2001): Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience 104:667-676.
26. Meggs WJ (1995): Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity. Environ Health Perspect 103:54-56.
27. Meggs WJ, Cleveland CH Jr (1993): Rhinolaryngoscopic examination of patients with the multiple chemical sensitivity syndrome. Arch Environ Health 48:14-18.
28. Meggs WJ, Dunn KA, Bloch RM, Goodman PE (1996): Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health 51:275-282.
29. Pujol J, Lopez A, Deus J, Cardoner N, Vallejo J, Capdevila A, Paus T (2002): Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. Neuroimage 15:847-855.
30. Roland PE, Zilles K (1994): Brain atlases - a new research tool. Trends Neurosci 17:458-467.
31. Sandstrom M, Lyskov E, Berglund A, Medvedev S, Mild KH (1997): Neurophysiological effects of flickering light in patients with perceived electrical hypersensitivity. J Occup Environ Med 39:15-22.
32. Savic I (2002): Imaging of brain activation by odourants in humans. Curr Opin Neurobiol 2:455-461.
33. Savic I, Berglund H (2004): Passive perception of odors and semantic circuits. Hum Brain Mapp 21:271-278.
34. Savic I, Gulyas B, Larsson M, Roland P (2000): Olfactory functions are mediated by parallel and hierarchical processing. Neuron 26:735-745.
35. Savic I, Berglund H, Gulyas B, Roland P (2001): Smelling of odorous sex hormone-like compounds causes sex differentiated hypothalamic activations in humans. Neuron 31:661-668.
36. Savic I, Gulyas B, Berglund H (2002): Odorant differentiated pattern of cerebral activation: comparison of acetone and vanillin. Hum Brain Mapp 17:17-27.
37. Savic I, Berglund H, Lindström P (2005): Brain response to putative pheromones in homosexual men. Proc Natl Acad Sci U S A 102:7356-7361.
38. Sobel N, Desmond JE, Glover GH, Goode RL, Sullivan EV, Gabrielli JD (1998): Sniffing and smelling: separate subsytems in the human olfactory cortex. Nature 392:282-286.
39. Sobel N, Prabhakaran V, Hartley CA, Desmond JE, Glover GH, Sullivan EV, Gabrieli JD (1999): Blind smell: brain activation induced by an undetected air-borne chemical. Brain 122:209-217.
40. Takahashi T, Kawasaki Y, Kurokawa K, Hagino H, Nohara S, Yamashita I, Nakamura K, Murata M, Matsui M, Suzuki M, Seto H, Kurachi M (2002): Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study. Schizophr Res 55:69-81.
41. Vogt BA, Nimchinsky EA, Vogt LJ, Hof PR (1995): Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol 359:490-506.
42. Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans A, Olivier A, Melanson D, Leroux G (1992): Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 42:1743-1750.
43. Wessely S, Nimnuan C, Sharpe M (1999): Functional somatic syndromes: one or many? Lancet 354:936-939.
44. Zald DH, Pardo JV (1997): Emotion, olfaction, and the human amygdala: amygdala activation during aversive olfactory stimulation. Proc Natl Acad Sci U S A 94:4119-4124.
45. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992): Functional localization and lateralization of human olfactory cortex. Nature 360:339-340.