Sp1 elements regulate transcriptional activity within the murine toll-like receptor 4 promoter

Surgical Infections

Volumn 7, Issue 6, 2006, Pages 489-499

  Wasiluk, Karen R ^a   McCulloch, Karen A ^a   Banton, Kaysie L ^a   Dunn, David L ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; LUCIFERASE; MITHRAMYCIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; LIPOPOLYSACCHARIDES; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33847402015     PISSN: 10962964     EISSN: None     Source Type: Journal    
DOI: 10.1089/sur.2006.7.489     Document Type: Article

References (31)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310.
2. Lowry SF. Cytokine mediators of immunity and inflammation. Arch Surg 1993;128:1235-1241.
3. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397.
4. Schwandner R, Dziarski R, Wesche H, et al. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. J Biol Chem 1999;274:17406-17409.
5. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001;410:1099-1103.
6. Hemmi H, Takeuchi O, Kawai T, el al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-745.
7. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998;282:2085-2088.
8. Qureshi ST, Lariviere L, Leveque G, et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999;189:615-625.
9. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product. J Immunol 1999;162:3749-3752.
10. Shimazu R, Akashi S, Ogata H, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999;189:1777-1782.
11. Schromm AB, Lien E, Henneke P, et al. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med 2001;194:79-88.
12. Tobias PS, Soldau K, Gegner JA, et al. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem 1995;270:10482-10488.
13. Wright SD, Ramos RA, Tobias PS, et al. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-1433.
14. Haziot A, Ferrero E, Kontgen F, et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 1996;4:407-414.
15. Moore KJ, Andersson LP, Ingalls RR, et al. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol 2000;165:4272-4280.
16. Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003;15:396-401.
17. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-260.
18. Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998;2:253-258.
19. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002;20:197-216.
20. Blume SW, Snyder RC, Ray R, et al. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest 1991;88:1613-1621.
21. Morrison DC. Antibiotic-mediated release of endotoxin and the pathogenesis of gram-negative sepsis. Prog Clin Biol Res 1998;397:199-207.
22. Opal SM, Gluck T. Endotoxin as a drug target. Crit Care Med 2003;31:S57-S64.
23. Rehli M, Poltorak A, Schwarzfischer L, et al. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem 2000;275:9773-9781.
24. Matsuguchi T, Musikacharoen T, Ogawa T, et al. Gene expression of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J Immunol 2000;165:5767-5772.
25. Oshikawa K, Sugiyama Y. Regulation of toll-like receptor 2 and 4 gene expression in murine alveolar macrophages. Exp Lung Res 2003;29:401-412.
26. Fan J, Kapus A, Marsden PA, et al. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol 2002;168:5252-5259.
27. Haehnel V, Schwarzfischer, Fenton MJ, et al. Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages. J Immunol 2002;168:5629-5637.
28. Musikacharoen T, Matsuguchi T, Kikuchi T, et al. NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression. J Immunol 2001;166:4516-4524.
29. Wang T, Lafuse WP, Zwilling BS. NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J Immunol 2001;167:6924-6932.
30. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001;413:732-738.
31. Heinz S, Haehnel V, Karaghiosoff M, et al. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem 2003;278:21502-21509.