A primary subcutaneous infection with Paracoccidioides brasiliensis leads to immunoprotection or exacerbated disease depending on the route of challenge

Microbes and Infection

Volumn 9, Issue 3, 2007, Pages 308-316

  Arruda, Celina ^a   Kashino, Suely S ^a   Fazioli, Raquel A ^a   Calich, Vera L G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antibodies; Cellular immunity; Cytokines; Immunoprotection; Paracoccidioides brasiliensis; Subcutaneous infection

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DISEASE COURSE; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST RESISTANCE; KAPLAN MEIER METHOD; LYMPH NODE CELL; NONHUMAN; PARACOCCIDIOIDES; PARACOCCIDIOIDES BRASILIENSIS; PRIORITY JOURNAL; SOUTH AMERICAN BLASTOMYCOSIS; SURVIVAL RATE;

ANIMALS; ANTIBODIES, FUNGAL; ANTIGENS, FUNGAL; CYTOKINES; FEMALE; HYPERSENSITIVITY, DELAYED; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED STRAINS; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; TH1 CELLS; TH2 CELLS; TIME FACTORS; VIRULENCE;

MUS; PARACOCCIDIOIDES BRASILIENSIS;

EID: 33847400184     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.12.005     Document Type: Article

References (29)

1. Cozad G.C., and Chang C.T. Cell mediated immunoprotection in blastomycosis. Infect. Immun. 28 (1980) 398-403
2. Cox R.A., Kennel W., Boncyk L., and Murphy J.W. Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis. Infect. Immun. 56 (1988) 13-17
3. Calich V.L.G., Singer-Vermes L.M., Siqueira A.M., and Burger E. Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis. Br. J. Exp. Pathol. 66 (1985) 585-594
4. Cano L.E., Singer-Vermes L.M., Vaz C.A.C., Russo M., and Calich V.L.G. Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response and specific isotype patterns. Infect. Immun. 63 (1995) 1777-1783
5. Mackinon J.E. Pathogenesis of South American blastomycosis. Trans. R. Soc. Trop. Med. Hyg. 53 (1959) 487-494
6. Morozumi P.A., Brummer E., and Stevens D.A. Strain differences in resistance to infection reversed by route of challenge: studies in blastomycosis. Infect. Immun. 34 (1981) 623-628
7. Bretcher P., Wei G., Menon J.N., and Bielefeldt-Ohmann H. Establishment of stable cell mediate immunity that makes susceptible mice resistant to Leishmania major. Science 257 (1992) 539-542
8. Calich V.L.G., and Blotta M.H.S.L. Pulmonary paracoccidioidomycosis. In: Fidel P.L., and Huffnagle G.B. (Eds). Fungal Immunology: From an Organ Perspective (2005), Springer, New York 201-228
9. Borges-Welmsley M.I., Chen D., Shu X., and Welmsley A.R. The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol. 10 (2002) 80-87
10. Kashino S.S., Fazioli R.A., Cafalli-Favati C., Meloni-Bruneri L.H., Vaz C.A.C., Burger E., and Calich V.L.G. Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response whereas susceptibility is associated with absence of IFN-γ production. J. Interf. Cyt. Res. 20 (2000) 89-97
11. Kashino S.S., Singer-Vermes L.M., Calich V.L.G., and Burger E. Alterations in the pathogenicity of one Paracoccidioides brasiliensis isolate do not correlate with its in vitro growth. Mycopathologia 111 (1990) 173-180
12. Fava-Netto C., Vegas V.S., Sciannaméa I.M., and Guarnieri E.D.B. Antígeno polissacarídico do Paracoccidioides brasiliensis. Estudo do tempo de cultivo do P. brasiliensis necessário ao preparo do antígeno. Rev. Inst. Med. Trop. São Paulo 11 (1969) 177-181
13. Fazioli R.A., Singer-Vermes L.M., Kashino S.S., Burger E., Franco M., Moschardi-Bacchi M., and Calich V.L.G. Delayed-type hypersensitivity response in an isogenic murine model of paracoccidioidomycosis. Mycopathologia 126 (1994) 137-146
14. Singer-Vermes L.M., Ciavaglia M.C., Kashino S.S., Burger E., and Calich V.L.G. The source of the growth-promoting factor(s) affects the plating efficiency of Paracoccidioides brasiliensis. J. Med. Vet. Mycol. 30 (1992) 261-264
15. Camargo Z.P., Taborda C.P., Rodrigues E.G., and Travassos L.R. The use of cell-free-antigens of Paracoccidioides brasiliensis in serological tests. J. Med. Vet. Mycol. 29 (1991) 31-38
16. Calich V.L.G., Singer-Vermes L.M., Russo M., Vaz C.A.C., and Burger E. Immunogenetics in paracoccidioidomycosis. In: Franco M., Lacaz C.S., Restrepo-Moreno A., and Del Negro G. (Eds). Paracoccidioidomycosis. first edition (1994), CRC Press, Boca Raton, Florida 151-173
17. Cher D.J., and Mossman T.R. Two types of helper T-cell clones. Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 138 (1987) 3688-3694
18. Nascimento R.F., Calich V.L.G., Rodrigues D., and Russo M. Dual role of nitric oxide in paracoccidioidomycosis: essential for resistance but overproduction associated with susceptibility. J. Immunol. 168 (2002) 4593-4600
19. Bocca A.L., Hayashi E.E., Pinheiro A.G., Furianetto A.B., Campanelli A.P., Cunha F.Q., and Figueiredo F. Treatment of Paracoccidioides brasiliensis infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune responses. J. Immunol. 162 (1988) 3056-3063
20. Burger E., Xidieh C.F., Sano A., Kashino S.S., Vaz C.A.C., Calich V.L.G., Singer-Vermes L.M., Nishimura K., and Miyaji M. Paracoccidioides brasiliensis infection in nude mice: studies with isolates differing in virulence and definition of their T-dependent and T-independent components. Am. J. Trop. Med. Hyg. 55 (1996) 391-398
21. Taborda C.P., Juliano M.A., Puccia R., Franco M., and Travassos L.R. Mapping the T cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response and protection against fungal infection in BALB/c mice. Infect. Immun. 66 (1998) 786-793
22. Arruda C., Valente-Ferreira R.C., Pina A., Kashino S.S., Fazioli R.A., Vaz C.A.C., Franco M.F., and Calich V.L.G. Dual role of IL-4 in pulmonary paracoccidioidomycosis. Endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern. Infect. Immun. 72 (2004) 3932-3940
23. Cano L.E., Kashino S.S., Arruda C., André D., Xidieh C.F., Singer-Vermes L.M., Vaz C.A.C., Burger E., and Calich V.L.G. Protective role of interferon-gamma in experimental pulmonary paracoccidioidomycosis. Infect. Immun. 66 (1998) 800-806
24. Souto J.F., Figueiredo F., Furlanetto A., Pfeffer K., Rossi M.A., and Silva J.S. Interferon-γ and tumor necrosis factor-α determine resistance to Paracoccidioides brasiliensis infection. Am. J. Pathol. 156 (2000) 1811-1820
25. Pina A., Valente-Ferreira R.C., Vaz C.A.C., Molinari-Madlum E.E.I.W., Keller A.C., and Calich V.L.G. Absence of IL-4 determines a less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. Infect. Immun. 72 (2004) 2369-2378
26. Romano C.C., Mendes-Giannini M.J.S., Duarte A.J.S., and Benard G. IL-12 and neutralization of endogenous IL-10 reverts the in vitro antigen-specific cellular immunosuppression of paracoccidioidomycosis patients. Cytokine 18 (2002) 149-157
27. Quah B.J.C., and O'Neil H.C. Maturation and function in dendritic cells for tolerance and immunity. J. Cell. Mol. Med. 9 (2005) 643-654
28. Lappin M.B., Weiss J.M., Delattre V., Mai B., Dittmar H., Maier C., Grabbe K.S., Martin S., and Simon J.C. Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 98 (1999) 181-188
29. Ferreira K.S., and Almeida S.R. Immunization of susceptible mice with gp43-pulsed dendritic cells induces an increase of pulmonary paracoccidioidomycosis. Immunol. Lett. 1003 (2006) 121-126