Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice

Reproduction

Volumn 133, Issue 1, 2007, Pages 21-27

  Nagaosa, Kaz ^a   Kishimoto, Atsushi ^a   Kizu, Ryoichi ^a,b   Nakagawa, Akihisa ^a,c   Shiratsuchi, Akiko ^a   Nakanishi, Yoshinobu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; BUSULFAN; FLUTAMIDE; TOXIN; VINCLOZOLIN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; BLOOD TESTIS BARRIER; CONTROLLED STUDY; GONAD FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK REDUCTION; SEMINIFEROUS TUBULE; SPERMATOGENESIS;

ANDROGEN ANTAGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-TESTIS BARRIER; BUSULFAN; FLUTAMIDE; MALE; MICE; MICROINJECTIONS; OXAZOLES; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TOXICITY TESTS;

ANIMALIA; MUS;

EID: 33847395764     PISSN: 14701626     EISSN: None     Source Type: Journal    
DOI: 10.1530/REP-06-0236     Document Type: Article

References (20)

1. Anway MD, Cupp AS, Uzumcu M & Skinner MK 2005 Epigenetic transgenerational actions of endocrine disruptors and male infertility. Science 308 1466-1469.
2. Brinster RL & Zimmermann JW 1994 Spermatogenesis following male germ-cell transplantation. PNAS 91 11298-11302.
3. Bucci LR & Meistrich ML 1987 Effects of busulfan on murine spermatogenesis: cytotoxicity, sterility, sperm abnormalities, and dominant lethal mutations. Mutation Research 176 259-268.
4. Cook JC, Mullin LS, Frame SR & Biegel LB 1993 Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats. Toxicology and Applied Pharmacology 119 195-204.
5. Gray LE Jr, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DN, Wilson V. Price M, Hotchkiss A, Orlando E & Guillette L 2001 Effects of environmental antiandrogens on reproductive development in experimental animals. Human Reproduction Update 7 248-264.
6. Guttman JA, Li Y, Wickham ME, Deng W, Vogl AW & Finlay BB 2006 Attaching and effacing pathogen-induced tight junction disruption in vivo. Cellular Microbiology 8 634-645.
7. Hess RA 1990 Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biology of Reproduction 43 525-542.
8. Kawasaki Y, Nakagawa A, Nagaosa K, Shiratsuchi A & Nakanishi Y 2002 Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells. Journal of Biological Chemistry 277 27559-27566.
9. Kelce WR, Monosson E, Gamcsik MP, Laws SC & Gray LE 1994 Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicology and Applied Pharmacology 126 276-285.
10. Kubota K, Ohsako S, Kurosawa S, Takeda K, Qing W, Sakaue M, Kawakami T, Ishimura R & Tohyama C 2003 Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat. Journal of Reproduction and Development 49 403-412.
11. Lui W-Y & Lee WM 2006 Regulation of junction dynamics in the testes-transcriptional and post-transcriptional regulations of cell junction proteins. Molecular and Cellular Endocrinology 250 25-35.
12. Lui W-Y, Mruk D, Lee WM & Cheng CY 2003 Sertoli cell tight junction dynamics: their regulation during spermatogenesis. Biology of Reproduction 68 1087-1097.
13. Maeda Y, Shiratsuchi A, Namiki M & Nakanishi Y 2002 Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death and Differentiation 9 742-749.
14. Nakagawa A, Nagaosa K, Hirose T, Tsuda K, Hasegawa K, Shiratsuchi A & Nakanishi Y 2004 Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat. Development, Growth and Differentiation 46 283-298.
15. Nakagawa A, Shiratsuchi A, Tsuda K & Nakanishi Y 2005 In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells. Molecular Reproduction and Development 71 166-177.
16. O'Connor JC, Frame SR & Ladics GS 2002 Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicological Sciences 69 92-108.
17. Ogawa T, Aréchaga JM, Avarbock MR & Brinster RL 1997 Transplantation of testis germinal cells into mouse seminiferous tubules. International Journal of Developmental Biology 41 111-122.
18. Russell LD, Ettlin RA, Sinha Hikim AP & Clegg ED 1990 Staging for Laboratory Species, Histological and Histopathological Evaluation of the Testis, pp 62-194.
19. US Environmental Protection Agency 1998 Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) final report.
20. Xia W, Mruk DD, Lee WM & Cheng CY 2005 Cytokines and junction restructuring during spermatogenesis - a lesson to learn from the testis. Cytokine and Growth Factor Reviews 16 469-493.