D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: A comparative immunohistochemical study with KIT (CD117) and CD30

Modern Pathology

Volumn 20, Issue 3, 2007, Pages 320-325

  Lau, Sean K ^a   Weiss, Lawrence M ^a   Chu, Peiguo G ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

CD30; D2 40; Embryonal carcinoma; KIT; Seminoma

Indexed keywords

CD30 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D2 40; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHORIOCARCINOMA; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; EMBRYONAL CARCINOMA; GERM CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; TERATOMA; YOLK SAC TUMOR;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD30; CARCINOMA, EMBRYONAL; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROTO-ONCOGENE PROTEINS C-KIT; SEMINOMA; TESTICULAR NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 33847394606     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800749     Document Type: Article

References (28)

1. Parkinson MC, Harland SJ, Harnden P, et al. The role of the histopathologist in the management of testicular germ cell tumour in adults. Histopathology 2001;38:183-194.
2. Tickoo SK, Hutchinson B, Bacik J, et al. Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. Int J Surg Pathol 2002;10:23-32.
3. Ulbright TM. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol 2005;18:S61-S79.
4. Pallesen G, Hamilton-Dutoit SJ. Ki-1 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma. Am J Pathol 1988;133:446-450.
5. Ferreiro JA. Ber-H2 expression in testicular germ cell tumors. Hum Pathol 1994;25:522-524.
6. Durkop H, Foss HD, Eitelbach F, et al. Expression of the CD30 antigen in non-lymphoid tissues and cells. J Pathol 2000;190:613-618.
7. Leroy X, Augusto D, Leteurtre E, et al. CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma. J Histochem Cytochem 2002;50:283-285.
8. Tsuura Y, Hiraki H, Watanabe K, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch 1994;424:135-141.
9. Izquierdo MA, Van der Valk P, Van Ark-Otte J, et al. Differential expression of the c-kit proto-oncogene in germ cell tumours. J Pathol 1995;177:253-258.
10. Strohmeyer T, Reese D, Press M, et al. Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue. J Urol 1995;153:511-515.
11. Tian Q, Frierson Jr HF, Krystal GW, et al. Activating c-kit gene mutations in human germ cell tumors. Am J Pathol 1999;154:1643-1647.
12. Hittmair A, Rogatsch H, Hobisch A, et al. CD30 expression in seminoma. Hum Pathol 1996;27:1166-1171.
13. Suster S, Moran CA, Dominguez-Malagon H, et al. Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. Hum Pathol 1998;29:737-742.
14. Cheville JC, Rao S, Iczkowski KA, et al. Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 2000;113:583-588.
15. Biermann K, Klingmuller D, Koch A, et al. Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas. Histopathology 2006;49:290-297.
16. Marks A, Sutherland DR, Bailey D, et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer 1999;80:569-578.
17. Bailey D, Baumal R, Law J, et al. Production of a monoclonal antibody specific for seminomas and dysgerminomas. Proc Natl Acad Sci USA 1986;83:5291-5295.
18. Bailey D, Marks A, Stratis M, et al. Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. Mod Pathol 1991;4:167-171.
19. Sonne SB, Herlihy AS, Hoei-Hansen CE, et al. Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours. Virchows Arch 2006;449:200-206.
20. Giwercman A, Marks A, Bailey D, et al. A monoclonal antibody as a marker for carcinoma in situ germ cells of the human adult testis. APMIS 1988;96:667-670.
21. Giwercman A, Cantell L, Marks A. Placental-like alkaline phosphatase as a marker of carcinoma-in-situ of the testis. Comparison with monoclonal antibodies M2A and 43-9F. APMIS 1991;99:586-594.
22. Eble JN, Sauter G, Epstein JI, et al. World health organization classification of tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press: Lyon, 2004.
23. Segelov E, Cox KM, Raghavan D, et al. The impact of histological review on clinical management of testicular cancer. Br J Urol 1993;71:736-738.
24. Lee AH, Mead GM, Theaker JM. The value of central histopathological review of testicular tumours before treatment. BJU Int 1999;84:75-78.
25. Delaney RJ, Sayers CD, Walker MA, et al. The continued value of central histopathological review of testicular tumours. Histopathology 2005;47:166-169.
26. Battifora H, Sheibani K, Tubbs RR, et al. Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma. Cancer 1984;54:843-848.
27. Ramaekers F, Feitz W, Moesker O, et al. Antibodies to cytokeratin and vimentin in testicular tumour diagnosis. Virchows Arch A Pathol Anat Histopathol 1985;408:127-142.
28. Nakagawa Y, Perentes E, Ross GW, et al. Immunohistochemical differences between intracranial germinomas and their gonadal equivalents. An immunoperoxidase study of germ cell tumors with epithelial membrane antigen, cytokeratin, and vimentin. J Pathol 1988;156:67-72.