Levosimendan in septic shock: Another piece in the puzzle, but many pieces are still lacking

Intensive Care Medicine

Volumn 33, Issue 3, 2007, Pages 403-405

  De Backer, Daniel ^a   Taccone, Fabio Silvio ^a   Radermacher, Peter ^b  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; LEVOSIMENDAN; NORADRENALIN;

ARTERIAL CARBON DIOXIDE TENSION; ATELECTASIS; CELL ENERGY; CELL RESPIRATION; DRUG EFFICACY; EDITORIAL; HEART OUTPUT; HEART RATE; LACTIC ACIDOSIS; MESENTERY BLOOD FLOW; MESENTERY BLOOD VESSEL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PERFUSION; RESPIRATORY QUOTIENT; SEPTIC SHOCK; SKELETAL MUSCLE; SPLANCHNIC BLOOD FLOW; STOMACH MUCOSA; SYSTEMIC CIRCULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CARDIOTONIC AGENTS; HYDRAZONES; PYRIDAZINES; SHEEP; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION;

EID: 33847370739     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-006-0520-z     Document Type: Editorial

References (26)

1. Rivers E, Nguyen B, Havstadt S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368-1377
2. 2 dependency exist in critically ill septic patients? Am J Respir Crit Care Med 157:1219-1225
3. Poeze M, Solberg BC, Greve JW, Ramsay G (2005) Monitoring global volume-related hemodynamic or regional variables after initial resuscitation: what is a better predictor of outcome in critically ill septic patients? Crit Care Med 33:2494-2500
4. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98-104
5. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent J-L (2004) Persistent microvasculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32:1825-1831
6. De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL (2006) The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34:403-408
7. Vogt J, Reinelt H, Radermacher P (1997) Dobutamine and the oxygen uptake/supply relationship in sepsis: from global to regional - nothing is simple and easy. Intensive Care Med 23:715-717
8. Ruokonen E, Uusaro A, Alhava E, Takala J (1997) The effect of dobutamine infusion on splanchnic blood flow and oxygen transport in patients with acute pancreatitis. Intensive Care Med 23:732-737
9. Papp Z, Csapo K, Pollesello P, Haikala H, Edes I (2005) Pharmacologic mechanisms contributing to the clinical efficacy of levosimendan. Cardiovasc Drug Rev 23:71-98
10. Behrends M, Peters J (2003) The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med 29:1802-1807
11. Morelli A, De Castro S, Teboul JL, Singer M, Rocco M, Conti G, De Luca L, Di Angelantonio E, Orecchioni A, Pandian NG, Pietropaoli P (2005) Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31:638-644
12. Morelli A, Teboul JL, Maggiore SM, Vieillard-Baron A, Rocco M, Conti G, De Gaetano A, Picchini U, Orecchioni A, Carbone I, Tritapepe L, Pietropaoli P, Westphal M (2006) Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. Crit Care Med 34:2287-2293
13. Noto A, Giacomini M, Palandi A, Stabile L, Reali-Forster C, Iapichino G (2005) Levosimendan in septic cardiac failure. Intensive Care Med 31:164-165
14. Oldner A, Konrad D, Weitzberg E, Rudehill A, Rossi P, Wanecek M (2001) Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 29:2185-2193
15. Faivre V, Kaskos H, Callebert J, Losser MR, Milliez P, Bonnin P, Payen D, Mebazaa A (2005) Cardiac and renal efects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits. Anesthesiology 103:514-521
16. Dubin A, Murias G, Sottile JP, Pozo M, Baran M, Edul VS, Canales H, Etcheverry G, Maskin B, Estenssoro E (2006) Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. Intensive Care Med. DOI 10.1007/s00134-006-519-5
17. Asfar P, De Backer D, Meier-Hellmann A, Radermacher P, Sakka SG (2004) Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. Crit Care 8:170-179
18. Edouard AR, Degremont AC, Duranteau J, Pussard E, Berdeaux A, Samii K (1994) Heterogenous regional vascular responses to simulated transient hypovolemia in man. Intensive Care Med 20:414-420
19. Riddez L, Hahn RG, Birsmar B, Strandberg A, Svensen C, Hedenstierna G (1997) Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers. Crit Care Med 25:635-640
20. Schwarte LA, Picker O, Bornstein SR, Fournell A, Scheeren TW (2005) Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med 33:135-142
21. Ozdem SS, Yalcin O, Meiselman HJ, Baskurt OK, Usta C (2006) The role of potassium channels in the relaxant effect of levosimendan in rat small mesenteric arteries. Cardiovasc Drugs Ther 20:123-127
22. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA (2002) Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 346:1281-1286
23. Korvald C, Elvenes OP, Myrmel T (2000) Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol 278:H1345-H1351
24. Kopustinskiene DM, Posello P, Saris NE (2001) Levosimendan is a mitochondrial K(ATP) channel opener. Eur J Pharmacol 428:311-314
25. Kopustinskiene DM, Posello P, Saris NE (2004) Potassium-specific effects of levosimendan on heart mitochondria. Biochem Pharmacol 68:807-812
26. Matejovic M, Krouzecky A, Radej J, Novak I (2005) Successful reversal of resistant hypodynamic septic shock with levosimendan. Acta Anasethesiol Scand 49:127-128