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Volumn 110, Issue 2, 2007, Pages 130-136

TGF-β1 as a pathophysiological factor in fracture healing;TGF-β1 als pathophysiologischer faktor bei der frakturheilung

Author keywords

BMP; Bone growth factors; Delayed union; Fracture healing; Pseudarthrosis; TGF 1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

EID: 33847350542     PISSN: 01775537     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00113-006-1199-x     Document Type: Article
Times cited : (21)

References (37)
  • 1
    • 84995865418 scopus 로고
    • Regenerating bone marrow produces a potent growth-promoting activity to osteogenic cells
    • Bab I, Gazit D, Muhlrad A, Shteyer A (1988) Regenerating bone marrow produces a potent growth-promoting activity to osteogenic cells. Endocrinology 123: 345-352
    • (1988) Endocrinology , vol.123 , pp. 345-352
    • Bab, I.1    Gazit, D.2    Muhlrad, A.3    Shteyer, A.4
  • 2
    • 0028362420 scopus 로고
    • Role of active and latent transforming growth factor beta in bone formation
    • Bonewald LF, Dallas SL (1994) Role of active and latent transforming growth factor beta in bone formation. J Cell Biochem 55: 350-357
    • (1994) J Cell Biochem , vol.55 , pp. 350-357
    • Bonewald, L.F.1    Dallas, S.L.2
  • 3
    • 16344369209 scopus 로고    scopus 로고
    • Connective tissue growth factor causes peristent proalpha 2 (I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
    • Chujo S, Shirasaki F et al. (2005) Connective tissue growth factor causes peristent proalpha 2 (I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol 203(2): 447-456
    • (2005) J Cell Physiol , vol.203 , Issue.2 , pp. 447-456
    • Chujo, S.1    Shirasaki, F.2
  • 4
    • 0035815750 scopus 로고    scopus 로고
    • Authentic matrix vesicles contain active metalloproteases (MMP). A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta
    • D'Angelo M, Billings PC, Pacifici M et al. (2001) Authentic matrix vesicles contain active metalloproteases (MMP). A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem 276: 11347-11353
    • (2001) J Biol Chem , vol.276 , pp. 11347-11353
    • D'Angelo, M.1    Billings, P.C.2    Pacifici, M.3
  • 5
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn TA (1998) The cell and molecular biology of fracture healing. Clin Orthopaed Rel Res 355S: 7-21
    • (1998) Clin Orthopaed Rel Res , vol.355 S , pp. 7-21
    • Einhorn, T.A.1
  • 6
    • 0025043963 scopus 로고
    • The osteogenic response to distant skeletal injury
    • Einhorn TA, Simon G, Devlin VJ et al. (1990) The osteogenic response to distant skeletal injury. J Bone Joint Surg Am 72: 1374-1378
    • (1990) J Bone Joint Surg Am , vol.72 , pp. 1374-1378
    • Einhorn, T.A.1    Simon, G.2    Devlin, V.J.3
  • 7
    • 0032841147 scopus 로고    scopus 로고
    • Does adult fracture repair recapitulate embryonic skeletal formation?
    • Ferguson C, Alpern E, Miclau T, Helms JA (1999) Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 87: 57-66
    • (1999) Mech Dev , vol.87 , pp. 57-66
    • Ferguson, C.1    Alpern, E.2    Miclau, T.3    Helms, J.A.4
  • 8
    • 0025314458 scopus 로고
    • Regenerating marrow induces systemic increase in osteo- and chondrogenesis
    • Gazit D, Karmish M, Holzman L, Bab I (1990) Regenerating marrow induces systemic increase in osteo- and chondrogenesis. Endocrinology 126: 2607-2613
    • (1990) Endocrinology , vol.126 , pp. 2607-2613
    • Gazit, D.1    Karmish, M.2    Holzman, L.3    Bab, I.4
  • 9
    • 0033145647 scopus 로고    scopus 로고
    • Recombinant TGF-beta1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice
    • Gazit D, Zilberman Y, Turgeman G et al. (1999) Recombinant TGF-beta1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice. J Cell Biochem 73: 379-389
    • (1999) J Cell Biochem , vol.73 , pp. 379-389
    • Gazit, D.1    Zilberman, Y.2    Turgeman, G.3
  • 10
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld LC, Cullinane DM, Barnes GL et al. (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88: 873-884
    • (2003) J Cell Biochem , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3
  • 11
    • 0033975065 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in human bone regeneration
    • Groeneveld EH, Burger EH (2000) Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol 142: 9-21
    • (2000) Eur J Endocrinol , vol.142 , pp. 9-21
    • Groeneveld, E.H.1    Burger, E.H.2
  • 12
    • 0017076151 scopus 로고
    • Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: Retrospective and prospective analyses
    • Gustilo RB, Anderson JT (1976) Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am 58: 453-458
    • (1976) J Bone Joint Surg Am , vol.58 , pp. 453-458
    • Gustilo, R.B.1    Anderson, J.T.2
  • 13
    • 0021227567 scopus 로고
    • Problems in the management of type III (severe) open fractures: A new classification of type III open fractures
    • Gustilo RB, Mendoza RM, Williams DN (1984) Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma 24: 742-746
    • (1984) J Trauma , vol.24 , pp. 742-746
    • Gustilo, R.B.1    Mendoza, R.M.2    Williams, D.N.3
  • 14
    • 3342974617 scopus 로고    scopus 로고
    • Effects of bone morphogenetic protein and transforming growth fractor-beta on biomechanical property for fracture healing in rabbit ulna
    • He XB, Lu WZ, Tang KL et al. (2003) Effects of bone morphogenetic protein and transforming growth fractor-beta on biomechanical property for fracture healing in rabbit ulna. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17: 185-188
    • (2003) Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi , vol.17 , pp. 185-188
    • He, X.B.1    Lu, W.Z.2    Tang, K.L.3
  • 15
    • 0025340885 scopus 로고
    • Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur
    • Joyce ME, Roberts AB, Sporn MB, Bolander ME (1990) Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110: 2195-2207
    • (1990) J Cell Biol , vol.110 , pp. 2195-2207
    • Joyce, M.E.1    Roberts, A.B.2    Sporn, M.B.3    Bolander, M.E.4
  • 16
    • 0036032292 scopus 로고    scopus 로고
    • 14a. Kandziora F, Pflugmacher R, Scholz M et al. (2002) Comparison of BMP-2 and combined IGF-I/TGF-ss1 application in a sheep cervical spine fusion model. Eur Spine J 11(5). 482-493
    • 14a. Kandziora F, Pflugmacher R, Scholz M et al. (2002) Comparison of BMP-2 and combined IGF-I/TGF-ss1 application in a sheep cervical spine fusion model. Eur Spine J 11(5). 482-493
  • 17
    • 0037228990 scopus 로고    scopus 로고
    • Mitogens are increased in the systemic circulation during bone callus healing
    • Kaspar D, Neidlinger-Wilke C, Holbein O et al. (2003) Mitogens are increased in the systemic circulation during bone callus healing. J Orthop Res 21: 320-325
    • (2003) J Orthop Res , vol.21 , pp. 320-325
    • Kaspar, D.1    Neidlinger-Wilke, C.2    Holbein, O.3
  • 18
    • 0031917287 scopus 로고    scopus 로고
    • Distraction bone healing versus osteotomy healing: A comparative biochemical analysis
    • Lammens J, Liu Z, Aerssens J et al. (1998) Distraction bone healing versus osteotomy healing: a comparative biochemical analysis. J Bone Miner Res 13: 279-286
    • (1998) J Bone Miner Res , vol.13 , pp. 279-286
    • Lammens, J.1    Liu, Z.2    Aerssens, J.3
  • 19
    • 0032951896 scopus 로고    scopus 로고
    • Molecular signaling in bone fracture healing and distraction osteogenesis
    • Liu Z, Luyten FP, Lammens J, Dequeker J (1999) Molecular signaling in bone fracture healing and distraction osteogenesis. Histol Histopathol 14: 587-595
    • (1999) Histol Histopathol , vol.14 , pp. 587-595
    • Liu, Z.1    Luyten, F.P.2    Lammens, J.3    Dequeker, J.4
  • 20
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas SC, Jilka RL (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332: 305-311
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 21
    • 0034016101 scopus 로고    scopus 로고
    • Positive and negative regulation of TGF-beta signaling
    • Miyazono K (2000) Positive and negative regulation of TGF-beta signaling. J Cell Sci 113 (Pt 7): 1101-1109
    • (2000) J Cell Sci , vol.113 , Issue.PART 7 , pp. 1101-1109
    • Miyazono, K.1
  • 22
    • 0031735025 scopus 로고    scopus 로고
    • Experimental models of fracture repair
    • Nunamaker DM (1998) Experimental models of fracture repair. Clin Orthopaed Rel Res 355S: 56-65
    • (1998) Clin Orthopaed Rel Res , vol.355 S , pp. 56-65
    • Nunamaker, D.M.1
  • 23
  • 24
    • 0037231431 scopus 로고    scopus 로고
    • Interaction between active motion and exogenous transforming growth factor Beta during tibial fracture repair
    • Park SH, O'Connor KM, McKellop H (2003) Interaction between active motion and exogenous transforming growth factor Beta during tibial fracture repair. J Orthop Trauma 17: 2-10
    • (2003) J Orthop Trauma , vol.17 , pp. 2-10
    • Park, S.H.1    O'Connor, K.M.2    McKellop, H.3
  • 25
    • 0031734292 scopus 로고    scopus 로고
    • The potential role of transforming growth factor beta in fracture healing
    • Rosier RN, O'Keefe RJ, Hicks DG (1998) The potential role of transforming growth factor beta in fracture healing. Clin Orthop Relat Res: S294-300
    • (1998) Clin Orthop Relat Res
    • Rosier, R.N.1    O'Keefe, R.J.2    Hicks, D.G.3
  • 26
    • 33749626666 scopus 로고    scopus 로고
    • Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation
    • Schmidmaier G, Herrmann S, Green J et al. (2006) Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone 39(5): 1156-1163
    • (2006) Bone , vol.39 , Issue.5 , pp. 1156-1163
    • Schmidmaier, G.1    Herrmann, S.2    Green, J.3
  • 27
    • 0142209286 scopus 로고    scopus 로고
    • Synergistic effect of IGF-I and TGF-beta1 on fracture healing in rats: Single versus combined application of IGF-I and TGF-beta1
    • Schmidmaier G, Wildemann B, Gabelein T et al. (2003) Synergistic effect of IGF-I and TGF-beta1 on fracture healing in rats: single versus combined application of IGF-I and TGF-beta1. Acta Orthop Scand 74: 604-610
    • (2003) Acta Orthop Scand , vol.74 , pp. 604-610
    • Schmidmaier, G.1    Wildemann, B.2    Gabelein, T.3
  • 28
    • 0036309479 scopus 로고    scopus 로고
    • Improvement of fracture healing by systemic administration of growth hormone and local application of insulin-like growth factor-1 and transforming growth factor-beta1
    • Schmidmaier G, Wildemann B, Heeger J et al. (2002) Improvement of fracture healing by systemic administration of growth hormone and local application of insulin-like growth factor-1 and transforming growth factor-beta1. Bone 31: 165-172
    • (2002) Bone , vol.31 , pp. 165-172
    • Schmidmaier, G.1    Wildemann, B.2    Heeger, J.3
  • 29
    • 0348135038 scopus 로고    scopus 로고
    • IGF-I and TGF-beta 1 incorporated in a poly(D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation in cell culture
    • Schmidmaier G, Wildemann B, Lubberstedt M et al. (2003) IGF-I and TGF-beta 1 incorporated in a poly(D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation in cell culture. J Biomed Mater Res 65B: 157-162
    • (2003) J Biomed Mater Res , vol.65 B , pp. 157-162
    • Schmidmaier, G.1    Wildemann, B.2    Lubberstedt, M.3
  • 30
    • 0027348143 scopus 로고
    • Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits
    • Terell TG, Working PK et al. (1993) Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits. Int Rev Exp Pathol 34 Pt B: 43-67
    • (1993) Int Rev Exp Pathol , vol.34 , Issue.PART B , pp. 43-67
    • Terell, T.G.1    Working, P.K.2
  • 31
    • 0036020551 scopus 로고    scopus 로고
    • The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect
    • Tieline L, Puolakkainen P, Pohjonen T et al. (2002) The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect. Biomaterials 23: 3817-3823
    • (2002) Biomaterials , vol.23 , pp. 3817-3823
    • Tieline, L.1    Puolakkainen, P.2    Pohjonen, T.3
  • 32
    • 0035081446 scopus 로고    scopus 로고
    • Inability of transforming growth factor-beta 1, combined with a bioabsorbable polymer paste, to promote healing of bone defects in the rat distal femur
    • Tielinen L, Manninen M, Puolakkainen P et al. (2001) Inability of transforming growth factor-beta 1, combined with a bioabsorbable polymer paste, to promote healing of bone defects in the rat distal femur. Arch Orthop Trauma Surg 121: 191-196
    • (2001) Arch Orthop Trauma Surg , vol.121 , pp. 191-196
    • Tielinen, L.1    Manninen, M.2    Puolakkainen, P.3
  • 33
    • 0020038192 scopus 로고
    • Die Klassifizierung des Weichteilschadens bei offenen und geschlossenen Frakturen. H. z
    • Tscherne H, Oestern HJ (1982) Die Klassifizierung des Weichteilschadens bei offenen und geschlossenen Frakturen. H. z. Unfallheilk 85
    • (1982) Unfallheilk , pp. 85
    • Tscherne, H.1    Oestern, H.J.2
  • 34
    • 0032008025 scopus 로고    scopus 로고
    • Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
    • Vortkamp A, Pathi S, Peretti GM et al. (1998) Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 71: 65-76
    • (1998) Mech Dev , vol.71 , pp. 65-76
    • Vortkamp, A.1    Pathi, S.2    Peretti, G.M.3
  • 35
    • 13844315153 scopus 로고    scopus 로고
    • Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways
    • Wang Y, Middleton F, Horton JA et al. (2004) Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 35: 1273-1293
    • (2004) Bone , vol.35 , pp. 1273-1293
    • Wang, Y.1    Middleton, F.2    Horton, J.A.3
  • 36
    • 0035991261 scopus 로고    scopus 로고
    • Systemic regulation of distraction osteogenesis: A cascade of biochemical factors
    • Weiss S, Baumgart R, Jochum M et al. (2002) Systemic regulation of distraction osteogenesis: a cascade of biochemical factors. J Bone Miner Res 17: 1280-1289
    • (2002) J Bone Miner Res , vol.17 , pp. 1280-1289
    • Weiss, S.1    Baumgart, R.2    Jochum, M.3
  • 37
    • 18144416223 scopus 로고    scopus 로고
    • TGF-beta1 as a marker of delayed fracture healing
    • Zimmermann G, Henle P, Kusswetter M et al. (2005) TGF-beta1 as a marker of delayed fracture healing. Bone 36: 779-785
    • (2005) Bone , vol.36 , pp. 779-785
    • Zimmermann, G.1    Henle, P.2    Kusswetter, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.