Scorpion venom increases mRNA expression of lung cytokines

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 146, Issue 4, 2007, Pages 581-587

  Andrade, Marcus V ^a   Lisboa, Felipe Assis ^a   Portugal, André Lopes ^a   Arantes, Rosa Maria Esteves ^a   Cunha Melo, José Renan ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Chemokines; Cytokines; Interleukin 6, interleukin 1 ; Messenger RNA; Pulmonary edema; Ribonuclease protection assay; Scorpion venom; Tityus serrulatus

Indexed keywords

CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; SCORPION VENOM; TITYUS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; INFLAMMATORY DISEASE; LUNG EDEMA; LUNG INJURY; MALE; NONHUMAN; PATHOPHYSIOLOGY; RAT; TOXIN ANALYSIS;

RATTUS; SCORPIONES; TITYUS SERRULATUS;

EID: 33847342157     PISSN: 10956433     EISSN: 15314332     Source Type: Journal    
DOI: 10.1016/j.cbpa.2006.01.031     Document Type: Article

References (48)

1. Abroug F., Boujdaria R., Belghith M., Nouira S., and Bouchoucha S. Cardiac dysfunction and pulmonary edema following scorpion envenomation. Chest 100 (1991) 1057-1059
2. Abroug F., Ayari M., Nouira S., Gamra H., Boujdaria R., Elatrous S., Ben Farhat M., and Bouchoucha S. Assessment of left ventricular function in severe scorpion envenomation: combined hemodynamic and echo-Doppler study. Intense Care Med. 21 (1995) 629-635
3. Amaral C.F., and Rezende N.A. Both cardiogenic and non-cardiogenic factors are involved in the pathogenesis of pulmonary oedema after scorpion envenoming. Toxicon 35 (1997) 997-998
4. Amaral C.F., de Rezende N.A., and Freire-Maia L. Acute pulmonary edema after Tityus serrulatus scorpion sting in children. Am. J. Cardiol. 71 (1993) 242-245
5. Amaral C.F., Barbosa A.J., Leite V.H., Tafuri W.L., and de Rezende N.A. Scorpion sting-induced pulmonary oedema: evidence of increased alveolocapillary membrane permeability. Toxicon 32 (1994) 999-1003
6. Amaral C.F., Dias M.B., Campolina D., Proietti F.A., and de Rezende N.A. Children with adrenergic manifestations of envenomation after Tityus serrulatus scorpion sting are protected from early anaphylactic antivenom reactions. Toxicon 32 (1994) 211-215
7. Andrade M.V., Souza D.G., de A.C.M., Cunha-Melo J.R., and Teixeira M.M. Evidence for a role of capsaicin-sensitive sensory nerves in the lung oedema induced by Tityus serrulatus venom in rats. Toxicon 40 (2002) 283-287
8. Andrade M.V., Caramez M.P.R., Abreu E.M.N.N., Dolnikoff M., Omar E.D., Velasco I.T., and Cunha-Melo J.R. Lung compliance, plasma electrolyte levels and acid-base balance are affected by scorpion envenomation in anesthetized rats under mechanical ventilation. Comp. Biochem. Physiol., C 138 (2004) 97-104
9. Andrade M.V., Hiragun T., and Beaven M.A. Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. J. Immunol. 172 (2004) 7254-7262
10. Azevedo A.D., Cunha-Melo J.R., and Freire-Maia L. Arterial hypertension and pulmonary edema induced by catecholamines in unanesthetized rats. Pharmacol. Res. Commun. 11 (1979) 157-167
11. Azevedo A.D., Silva A.B., Cunha-Melo J.R., and Freire-Maia L. Cardiovascular and respiratory effects induced by a purified scorpion toxin (tityustoxin) in unanesthetized rats. Toxicon 21 (1983) 753-759
12. Comellas A.P., Pesce L.M., Azzam Z., Saldias F.J., and Sznajder J.I. Scorpion venom decreases lung liquid clearance in rats. Am. J. Respir. Crit. Care Med. 167 (2003) 1064-1067
13. Cunha-Melo J.R., Gonzaga H.M., Alzamora F., and Freire-Maia L. Effects of purified scorpion toxin (tityustoxin) on gastric secretion in the rat. Toxicon 21 (1983) 843-848
14. Cupo P., Jurca M., Azevedo-Marques M.M., Oliveira J.S., and Hering S.E. Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects. Rev. Inst. Med. Trop. Sao Paulo 36 (1994) 67-76
15. D'Suze G., Comellas A., Pesce L., Sevcik C., and Sanchez-de-Leon R. Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanism. Toxicon 37 (1999) 173-180
16. D'Suze G., Moncada S., Gonzalez C., Sevcik C., Aguilar V., and Alagon A. Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting. Toxicon 41 (2003) 367-375
17. D'Suze G., Salazar V., Diaz P., Sevcik C., Azpurua H., and Bracho N. Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams. Toxicon 44 (2004) 851-860
18. De Matos I.M., Rocha O.A., Leite R., and Freire-Maia L. Lung oedema induced by Tityus serrulatus scorpion venom in the rat. Comp. Biochem. Physiol., C 118 (1997) 143-148
19. De Matos I.M., Talvani A., Rocha O.O., Freire-Maia L., and Teixeira M.M. Evidence for a role of mast cells in the lung edema induced by Tityus serrulatus venom in rats. Toxicon 39 (2001) 863-867
20. de Rezende N.A., Chavez-Olortegui C., and Amaral C.F. Is the severity of Tityus serrulatus scorpion envenoming related to plasma venom concentrations?. Toxicon 34 (1996) 820-823
21. Freire-Maia L. Neurotoxins as tools for physiological investigation. Physiologist 26 (1983) 381-390
22. Freire-Maia L., and De Matos I.M. Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat. Toxicon 31 (1993) 1207-1210
23. Freire-Maia L., Cunha-Melo J.R., Futuro-Neto H.A., Azevedo A.D., and Weinberg J. Cholinergic and adrenergic effects of tityustoxin. Gen. Pharmacol. 7 (1976) 115-121
24. Freire-Maia L., Almeida H.O., Cunha-Melo J.R., Azevedo A.D., and Barroso J. Mechanism of the pulmonary edema induced by intravenous injection of scorpion toxin in the rat. Agents Actions 8 (1978) 113-118
25. Freire-Maia L., Campos J.A., and Amaral C.F. Approaches to the treatment of scorpion envenoming. Toxicon 32 (1994) 1009-1014
26. Fukuhara Y.D., Reis M.L., Dellalibera-Joviliano R., Cunha F.Q., and Donadi E.A. Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting. Toxicon 41 (2003) 49-55
27. Gueron M., and Ilia R. Non-cardiogenic pulmonary oedema after scorpion envenomation: a true entity?. Toxicon 34 (1996) 393-395
28. Gueron M., Adolph R.J., Grupp I.L., Gabel M., Grupp G., and Fowler N.O. Hemodynamic and myocardial consequences of scorpion venom. Am. J. Cardiol. 45 (1980) 979-986
29. Gueron M., Margulis G., and Sofer S. Echocardiographic and radionuclide angiographic observations following scorpion envenomation by Leiurus quinquestriatus. Toxicon 28 (1990) 1005-1009
30. Hering S.E., Jurca M., Vichi F.L., Azevedo-Marques M.M., and Cupo P. 'Reversible cardiomyopathy' in patients with severe scorpion envenoming by Tityus serrulatus: evolution of enzymatic, electrocardiographic and echocardiographic alterations. Ann. Trop. Paediatr. 13 (1993) 173-182
31. Karnad D.R. Haemodynamic patterns in patients with scorpion envenomation. Heart 79 (1998) 485-489
32. Magalhaes M.M., Pereira M.E., Amaral C.F., Rezende N.A., Campolina D., Bucaretchi F., Gazzinelli R.T., and Cunha-Melo J.R. Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting. Toxicon 37 (1999) 1155-1164
33. Matos I.M., Souza D.G., Seabra D.G., Freire-Maia L., and Teixeira M.M. Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats. Eur. J. Pharmacol. 376 (1999) 293-300
34. Matos I.M., Teixeira M.M., Leite R., and Freire-Maia L. Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum. Eur. J. Pharmacol. 368 (1999) 231-236
35. Meki A.R., and Mohey El-Dean Z.M. Serum interleukin-1beta, interleukin-6, nitric oxide and alpha1-antitrypsin in scorpion envenomed children. Toxicon 36 (1998) 1851-1859
36. Mesquita M.B., Moraes-Santos T., and Moraes M.F. Phenobarbital blocks the lung edema induced by centrally injected tityustoxin in adult Wistar rats. Neurosci. Lett. 332 (2002) 119-122
37. Novoa E., D'Suze G., Winter M., Crespo A., Tortoledo M.A., Marcano H., Friedman E., Sevcik C., Zabner J., and Sanchez d.L. The indirect effect of Tityus discrepans on rabbit pulmonary vasculature. Respir. Physiol. Neurobiol. 134 (2003) 33-41
38. Pessini A.C., de Souza A.M., Faccioli L.H., Gregorio Z.M., and Arantes E.C. Time course of acute-phase response induced by Tityus serrulatus venom and TsTX-I in mice. Int. Immunopharmacol. 3 (2003) 765-774
39. Petricevich V.L. Effect of Tityus serrulatus venom on cytokine production and the activity of murine macrophages. Mediat. Inflamm. 11 (2002) 23-31
40. Petricevich V.L. Cytokine and nitric oxide production following severe envenomation. Curr. Drug Targets. Inflamm. Allergy 3 (2004) 325-332
41. Petricevich V.L., and Pena C.F. The dynamics of cytokine d nitric oxide secretion in mice injected with Tityus serrulatus scorpion venom. Mediat. Inflamm. 11 (2002) 173-180
42. Rahav G., and Weiss A.T. Scorpion sting-induced pulmonary edema. Scintigraphic evidence of cardiac dysfunction. Chest 97 (1990) 1478-1480
43. Silveira N.P., Moraes-Santos T., Azevedo A.D., and Freire-Maia L. Effects of Tityus serrulatus scorpion venom and one of its purified toxins (toxin gamma) on the isolated guinea-pig heart. Comp. Biochem. Physiol., C 98 (1991) 329-336
44. Sofer S., and Gueron M. Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects. Toxicon 26 (1988) 931-939
45. Sofer S., Shalev H., Weizman Z., Shahak E., and Gueron M. Acute pancreatitis in children following envenomation by the yellow scorpion Leiurus quinquestriatus. Toxicon 29 (1991) 125-128
46. Sofer S., Gueron M., White R.M., Lifshitz M., and Apte R.N. Interleukin-6 release following scorpion sting in children. Toxicon 34 (1996) 389-392
47. Teixeira A.L., and Teixeira M.M. Mechanisms involved in myocardial necrosis and pulmonary oedema after Tityus serrulatus scorpion envenomation. Trans. R. Soc. Trop. Med. Hyg. 97 (2003) 122
48. Troncon L.E., Santos A.A., Garbacio V.L., Secaf M., Verceze A.V., and Cunha-Melo J.R. Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin. Braz. J. Med. Biol. Res. 33 (2000) 1053-1058