Clinical effect of bisphosphonate and vitamin D on osteoporosis: Reappraisal of a multicenter double-blind clinical trial comparing etidronate and alfacalcidol

Journal of Bone and Mineral Metabolism

Volumn 25, Issue 2, 2007, Pages 130-137

  Fujita, Takuo ^a   Orimo, Hajime ^b   Inoue, Tetsuo ^c   Kaneda, Kiyoshi ^d   Sakurai, Minoru ^e   Morita, Rikushi ^f   Yamamoto, Kichizo ^g   Sugioka, Yoichi ^h   Inoue, Akio ⁱ   Takaoka, Kunio ^j   Yamamoto, Itsuo ^k   Hoshino, Yuichi ^l   Kawaguchi, Hiroshi ^m  

^a Katsuragi Hospital   (Japan)

^b Tokyo Metropolitan Univ Hlth Sci   (Japan)

^c Aoyama General Hospital   (Japan)

^d Bibai Rosai Hospital   (Japan)

^e Tohoku Central Hospital   (Japan)

^f SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^g Hakuai Hospital   (Japan)

^h KYUSHU ROSAI HOSPITAL   (Japan)

ⁱ Yanagawa Publ Hosp   (Japan)

^j OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^k Yamamoto Clinic   (Japan)

^l JICHI MEDICAL UNIVERSITY   (Japan)

^m UNIVERSITY OF TOKYO   (Japan)

more..

Author keywords

Alfacalcidol; DXA (dual energy X ray absorptiometry); Etidronate; Fracture; Osteoporosis

Indexed keywords

ALFACALCIDOL; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CALCIFEDIOL; CALCIUM; CHROMIUM; ETIDRONIC ACID; HYDROXYPROLINE; OSTEOCALCIN; PARATHYROID HORMONE; PHOSPHORUS; PLACEBO; VITAMIN D;

ADULT; AGED; ARTICLE; BONE DENSITY; CLINICAL TRIAL; COMPARATIVE STUDY; COMPRESSION FRACTURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG WITHDRAWAL; DUAL ENERGY X RAY ABSORPTIOMETRY; ELECTROLYTE DISTURBANCE; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; LOW DRUG DOSE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MOUTH DISEASE; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; OSTEOPOROSIS; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; SPINE FRACTURE; SPINE MALFORMATION; TABLET; THORACIC SPINE; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; X RAY FILM;

AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; CALCIUM; CREATININE; DOUBLE-BLIND METHOD; ETIDRONIC ACID; FEMALE; HUMANS; HYDROXYCHOLECALCIFEROLS; HYPERPARATHYROIDISM, SECONDARY; HYPERTHYROIDISM; MALE; MIDDLE AGED; OSTEOPOROSIS; VITAMIN D;

EID: 33847334302     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-006-0738-4     Document Type: Article

References (20)

1. M Sato W Graser 1990 Effect of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy J Bone Miner Res 5 31 40
2. A Carano SL Teitelbaum JD Konsek PH Schlesinger HC Blair 1990 Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro J Clin Invest 85 456 461
3. DE Hughes RR [tmp] MacDonald RGG Russell M Gowen 1989 Inhibition of osteoclasts-like cell formation by bisphosphonate in long term culture of human bone marrow J Clin Invest 83 1930 1935
4. RP Heaney PD Saville 1976 Etidronate disodium in postmenopausal osteoporosis Clin Pharmacol Ther 20 593 604
5. C Gennari 1980 Disodium etidronate treatment of osteoporosis A Caniggia Proceedings of the First International Symposium on Diphosphonate in Therapy, Pisa, Italy Via Mazzini Pisa 133 146
6. NB Watts ST Harris HK Genant RD Wasnich PD Miller RD Jackson AA Licata P Ross GC Woodson III MJ Yanover 1990 Intermittent cyclical etidronate treatment of postmenopausal osteoporosis N Engl J Med 323 73 79
7. A Cranney G Guyatt N Krolicki V Welch L Griffith JD Adachi B Shea P Tugwell G Wells Osteoporosis Research Advisory Group (ORAG) 2001 A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis Osteoporos Int 12 140 151
8. SM Ott GC Woodson WE Huffer PD Miller NB Watts 1994 Bone histomorphometric changes after cyclic therapy with phosphate and etidronate disodium in women with postmenopausal osteoporosis J Clin Endocrinol Metab 78 968 972
9. C Hasling P Charles FT Jensen L Mosekilde 1994 A comparison of the effects of oestrogen/progestogen, high-dose oral calcium, intermittent cyclic etidronate and an ADFR regime on calcium kinetics and bone mass in postmenopausal women with spinal osteoporosis Osteoporos Int 4 191 203
10. PD Miller NB Watts AA Licata ST Harris HK Genant RD Wasnich PD Jackson MS Hoseyni SL Schoenfeld DJ Valent GH Chesnut III 1997 Cyclical etidronate in the treatment of postmenopausal osteoporosis: efficacy and safety after seven years of treatment Am J Med 103 468 476
11. T Fujita 1992 Vitamin D in the treatment of osteoporosis Proc Soc Exp Biol Med 199 394 399
12. 3 Bone Miner 3 47 52
13. E Papadimitropoulos G Wells B Shea W Gillespie B Weaver Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women Endocr Rev 23 560 569
14. AP De Leenheer RM Bauwens 1985 Comparison of a cytosol radioreceptor assay with a radioimmunoassay for 1,25-dihydroxyvitamin D in serum or plasma Clin Chim Acta 152 143 154
15. JG Haddad KJ Chyu 1971 Competitive protein-binding radioassay for 25-hydroxycholecalciferol J Clin Endocrinol Metab 33 992 995
16. E Slatopolsky K Martin J Morrissey K Hruska 1982 Current concepts of the metabolism and radioimmunoassay of parathyroid hormone J Lab Clin Med 99 309 316
17. T Sone T Tomomitsu M Fukunaga 1995 Standardization of diagnosis with various dual X-ray absorptiometry systems (in Japanese) Osteoporosis Jpn 3 223 225
18. J Jowsey BL Riggs PJ Kelly DL Hoffman P Bordier 1971 The treatment of osteoporosis with disodium ethene-1,1-diphosphonate J Lab Clin Med 78 574 584
19. R Volkema F-J Vismans SE Papapoulos EK Pauwels OLM Bijvoet 1989 Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonates APD Bone Miner 5 183 192
20. T Storm C Thamsborg T Steiniche HK Genant OH Soerensen 1990 Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis N Engl J Med 322 1265 1271