Thiolation mediated Pegylation platform to generate functional universal red blood cells

Artificial Cells, Blood Substitutes, and Biotechnology

Volumn 35, Issue 1, 2007, Pages 107-118

  Nacharaju, Parimala ^a   Manjula, Belur N ^a   Acharya, Seetharama A ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTES; OXYGEN AFFINITY; PROTEIN AMINO GROUPS; RED BLOOD CELLS (RBC);

AMINO ACIDS; ANTIGENS; ARTIFICIAL ORGANS; BIOTECHNOLOGY; CELLS; OXYGEN; POLYETHYLENE GLYCOLS; PROTEINS;

BLOOD;

BLOOD GROUP ANTIGEN; MACROGOL 20000; MACROGOL 5000; MACROGOL DERIVATIVE; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; DRUG MIXTURE; ERYTHROCYTE; OXYGEN AFFINITY;

BLOOD GROUP ANTIGENS; BLOOD SUBSTITUTES; ELECTROSTATICS; ERYTHROCYTES; HUMANS; ISOANTIGENS; OXYGEN; POLYETHYLENE GLYCOLS; SULFHYDRYL COMPOUNDS;

EID: 33847332555     PISSN: 10731199     EISSN: 15324184     Source Type: Journal    
DOI: 10.1080/10731190600974657     Document Type: Article

References (14)

1. Jeong, S.T., Byun, S.M. (1996). Decreased agglutinability of methoxypolyethylene glycol attached red blood cells: Significance as a blood subsstitute. Art Cells Blood Subs. and Immob. Biotech. 24: 503-511.
2. Scott, M.D., Murad, K.L., Koumpouras, F., Talbot, M., Eaton, J.W. (1997). Chemical camouflage of antigenic determinations: Stealth erythrocytes. Proc. Natl. Acad. Sci. USA 94: 7566-7571.
3. Fisher, T.C., Armstrong, J.K. (2001). Red blood cells covalently bound with two different polyethylene glycol derivatives. US Patent 6312685.
4. Bradley, A.J., Murad, K.L., Regan, K.L., Scott, M.D. (2002). Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes: Size does matter. Biochim. Biophys. Acta. 1561: 147-158.
5. Sabolovic, D., Sestier, C., Perrotin, P., Guillet, R., Tefit, M., Boynard, M. (2000). Covalent binding of polyethylene glycol to the surface of red blood cells as detected and followed up by cell electrophoresis and rheological methods. Electrophoresis 21: 301-306.
6. Blackall, D.P., Armstrong, J.K., Meiselman, H.J., Fisher, T.C. (2001). Polyethylene glycol-coated red blood cells fail to bind glycophorin A-specific antibodies and are impervious to invasion by the Plasmodium falciparum malaria parasite. Blood 97: 551-556.
7. Bradley, A.J., Test, S.T., Murad, K.L., Mitsuyoshi, J., Scott, M.D. (2001). Interactions of IgM ABO antibodies and complement with methoxy-PEG-modified human RBCs. Transfusion 41: 1225-1233.
8. Mathur, S., Clark, B., Castro, G., Zhou, X.M., Bowers, S., Stassinopoulos, A. (2003). Efficient full unit Pegylation of human red blood cells (RBC) using linear methoxy-capped polyethylene glycol (mPEG). Blood 102: 556A.
9. Acharya, A.S., Manjula, B.N., Smith, P.K. (1996). Hemoglogin crosslinkers. US Patent 5585484.
10. Nacharaju, P., Boctor, F.N., Manjula, B.N., Acharya, S.A. (2004). Surface decoration of red blood cells with maleimidophenyl-polyethylene glycol facilitated by thiolation with iminothiolane: An approach to mask A, B, and D antigens to generate universal red blood cells. Transfusion 45: 374-383.
11. Manjula, B.N., Tsai, A., Upadhya, R., Perumalsamy, K., Smith, P.K., Malavalli, A., Vandegriff, K.,Winslow, R.M., Intaglietta,M., Prabhakaran, M., Friedman, J.M., Acharya, A.S. (2003). Site-specific PEGylation of hemoglobin at Cys-93(beta): Correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjug. Chem. 14: 464-472.
12. Avent, N.D., Reid, M.E. (2003). The Rh blood group system: A review. Blood 95: 375-387.
13. King, M.-J. (1994). Blood group antigens on human erythrocytes- distribution, structure and possible functions. Biochim. Biophys. Acta. 1197: 15-44.
14. Reid, M.E., Mohandas, N. (2004). Red blood cell blood group antigens: Structure and function. Seminars Hematol. 41: 93-117.