A sample preparation process for LC-MS/MS analysis of total protein drug concentrations in monkey plasma samples with antibody

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 847, Issue 2, 2007, Pages 133-141

  Ji, Qin C ^a   Rodila, Ramona ^a   El Shourbagy, Tawakol A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antibody binding; Bioanalytical assay validation; Kringle 5; LC MS MS; Protein quantitation; Solid phase extraction

Indexed keywords

BIOASSAY; BIOMARKERS; BIOMEDICAL ENGINEERING; DIAGNOSIS; LIQUID CHROMATOGRAPHY; LIVING SYSTEMS STUDIES; MASS SPECTROMETRY; SOLVENT EXTRACTION;

BIOANALYTICAL ASSAY VALIDATIONS; CLINICAL DIAGNOSTICS; COEFFICIENT OF DETERMINATION; ELISA; KRINGLE 5; PROTEIN QUANTITATIONS; SOLID PHASE EXTRACTIONS;

PROTEINS;

ANTIBODY; SERUM ALBUMIN;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); DENATURATION; DISSOCIATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SOLID PHASE EXTRACTION;

ANIMALS; ANTIBODIES; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; HAPLORHINI; MASS SPECTROMETRY; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION;

EID: 33847323404     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.09.039     Document Type: Article

References (12)

1. Oda Y., Huang K., Cross F.R., Cowburn D., and Chait B.T. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 6591
2. Mao Y., Moore R.J., Wagnon K.B., Pierce J.T., Debban K.H., Smith C.S., Dill J.A., and Fuciarelli A.F. Chem. Res. Toxicol. 11 (1998) 953
3. Barnidge D.R., Dratz E.A., Martin T., Bonilla L.E., Moran L.B., and Lindall A. Anal. Chem. 75 (2003) 445
4. Gerber S.A., Rush J., Stemman O., Kirschner M.W., and Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6941
5. Zhang F., Bartels M.J., and Stott W.T. Rapid Commun. Mass Spectrom. 18 (2004) 491
6. Ji Q.C., Rodila R., Gage E.M., and El-Shourbagy T.A. Anal. Chem. 75 (2003) 7008
7. Ji Q.C., Rodila R., Gage E.M., and El-Shourbagy T.A. Am. Pharm. Rev. 3 (2004) 84
8. Q.C. Ji, T.A. El-Shourbagy, 5th Annual Land O'Lakes Bioanalytical Conference, July 2004.
9. Lu H., Dhanabal M., Volk R., Waterman M.J.F., Ramchandran R., Knebelmann B., Segal M., and Sukhatme V.P. Biochem. Biophys. Res. Commun. 258 (1999) 668
10. Davidson D.J., Haskell C., Majest S., Kherzai A., Egan D.A., Walter K.A., Schneider A., Gubbins E.F., Solomon L., Chen Z., Lesniewski R., and Henkin J. Cancer Res. 65 (2005) 4663
11. Ji Q.C., Rodila R., Morgan S., Humerickhouse R.A., and El-Shourbagy T.A. Anal. Chem. 77 (2005) 5529
12. R. Rodila, J.C. Kim, Q.C. Ji, T.A. El-Shourbagy, Method validation for the determination of free and total concentration of rk5 in cynomolgus monkey plasma using equilibrium dialysis and LC/MS/MS detection, in preparation.