New insights into the pathology of multiple sclerosis: Towards a unified concept?

Journal of Neurology

Volumn 254, Issue 1 SUPPL., 2007, Pages

  Brück, Wolfgang ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Information; Multiple sclerosis; Neurodegeneration

Indexed keywords

ANTIGEN; GROWTH FACTOR; MYELIN PROTEIN; PROTEIN PRECURSOR;

AUTOIMMUNITY; AXONAL INJURY; BRAIN NERVE CELL; CELL HETEROGENEITY; CELL INFILTRATION; COMPREHENSION; CYTOTOXICITY; DEMYELINATION; GLIOSIS; HISTOPATHOLOGY; HUMAN; HYPOTHESIS; IMMUNOCOMPETENT CELL; INFLAMMATION; INTROSPECTION; KNOWLEDGE; MULTIPLE SCLEROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; T LYMPHOCYTE;

EID: 33847264050     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-007-1002-0     Document Type: Review

References (29)

1. Barkhof F, Bruck W, De Groot CJ, Bergers E, Hulshof S, Geurts J, Polman CH, van der Valk P (2003) Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch Neurol 60:1073-1081
2. Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 55:458-468
3. Barnett MH, Henderson AP, Prineas JW (2006) The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion. Mult Scler 12:121-132
4. Baumann N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871-927
5. Bitsch A, Wegener C, da Costa C, Bunkowski S, Reimers CD, Prange HW, Bruck W (1999) Lesion development in Marburg's type of acute multiple sclerosis: from inflammation to demyelination. Mult Scler 5:138-146
6. Bruck W (2005) Clinical implications of neuropathological findings in multiple sclerosis. J Neurol 252 Suppl 3:III10-III14
7. Bruck W (2005) The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J Neurol 252(Suppl 5):V3-V9
8. Diemel LT, Copelman CA, Cuzner ML (1998) Macrophages in CNS remyelination: friend or foe? Neurochem Res 23:341-347
9. Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399
10. Itoyama Y, Sternberger NH, Webster HD, Quarles RH, Cohen SR, Richardson EP Jr (1980) Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions. Ann Neurol 7:167-177
11. Kerschensteiner M, Gallmeier E, Behrens L et al. (1999) Activated human T-cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189:865-870
12. Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T (1999) Cortical lesions in multiple sclerosis. Brain 122:7-26
13. Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35:204-212
14. Kuhlmann T, Lingfeld G, Bitsch A, Schuchardt J, Bruck W (2002) Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125:2202-2212
15. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med Aug 15; 202(4):473-477
16. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47:707-717
17. Lucchinetti CF, Bruck W, Rodriguez M, Lassmann H (1996) Distinct patterns of multiple sclerosis pathology indicate heterogeneity of pathogenesis. Brain Pathol 6:259-274
18. Ludwin SK, Johnson ES (1981) Evidence for a "dying-back" gliopathy in demyelinating disease. Ann Neurol 9:301-305
19. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M (1999) Autoimmune T-cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49-55
20. Niehaus A, Shi J, Grzenkowski M et al. (2000) Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination. Ann Neurol 48:362-371
21. O'Connor KC, Appel H, Bregoli L et al. (2005) Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol 175:1974-1982
22. Peterson JW, Bo L, Mork S, Chang A, Trapp BD (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 150:389-400
23. Pittock SJ, McClelland RL, Achenbach SJ et al. (2005) Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease. J Neurol Neurosurg Psychiatry 76:1693-1697
24. Prineas JW, Graham JS (1981) Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 10:149-158
25. Stadelmann C, Kerschensteiner M, Misgeld T, Bruck W, Hohlfeld R, Lassmann H (2002) BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 125:75-85
26. Stegmuller J, Schneider S, Hellwig A, Garwood J, Trotter J (2002) AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. J Neurocytol 31:497-505
27. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285
28. Traugott U, Reinherz EL, Raine CS (1983) Multiple sclerosis. Distribution of T-cells, T-cell subsets and Ia-positive macrophages in lesions of different ages. J Neuroimmunol 4:201-221
29. Zhang Y, Da RR, Guo W et al. (2005) Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis. J Clin Immunol 25:254-264