Synthesis of pseudopeptides based l-tryptophan as a potential antimicrobial agent

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1601-1607

  Lv, Jian ^a   Yin, Liang ^a   Liu, Tingting ^b   Wang, Yongmei ^a  

^a NANKAI UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antimicrobial activity; Haemolytic assay; l Tryptophan; Pseudopeptides

Indexed keywords

ANTIINFECTIVE AGENT; PSEUDOPEPTIDE; PYRIDINE DERIVATIVE; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS; BACILLUS SUBTILIS; CANDIDA; CONCENTRATION RESPONSE; CRYPTOCOCCUS NEOFORMANS; DIAGNOSTIC VALUE; DRUG CYTOTOXICITY; DRUG POTENCY; ENTEROBACTER AEROGENES; ERYTHROCYTE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HEMOLYSIS; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; RHIZOPUS NIGRICANS; RHODOTORULA GLUTINIS; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BACTERIA; FUNGI; HEMOLYSIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PEPTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TRYPTOPHAN;

ASPERGILLUS; BACILLUS SUBTILIS; CANDIDA; ENTEROBACTER AEROGENES; ESCHERICHIA COLI; FILOBASIDIELLA NEOFORMANS; FUNGI; MICROCOCCUS LUTEUS; NEGIBACTERIA; POSIBACTERIA; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; RHIZOPUS STOLONIFER; RHODOTORULA GLUTINIS; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS;

EID: 33847232928     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.090     Document Type: Article

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23. 9 cells/mL) was mixed with 0.1 mL of test substances at a series of concentrations (1-4000 μg/mL). The mixtures were incubated at 37 °C for 1 h. After incubation, tubes were centrifuged at 2000g for 10 min. The supernatantes were transferred into 96-well polystyrene plates (Costar 3590, incorporated) and the optical density was measured at 540 nm using MTP120 microplate reader (Colona Electric, Japan). The values for 0% and 100% lysis were determined by incubating erythrocytes with PBS, and 0.1% (v/v) Triton X-100 (Amresco 0694), respectively. Assays were carried out in triplicate and the results were confirmed in three independent experiments.