Myth: Parenteral ketorolac provides more effective analgesia than oral ibuprofen

Canadian Journal of Emergency Medicine

Volumn 9, Issue 1, 2007, Pages 30-32

  Arora, Sanjay ^a   Wagner, Jonathan G ^a   Herbert, Mel ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Acute pain; Analgesia; Ibuprofen; Ketorolac

Indexed keywords

IBUPROFEN; KETOROLAC;

ANALGESIA; ARTICLE; CLINICAL TRIAL; DRUG COST; DRUG EFFICACY; EMERGENCY MEDICINE; HUMAN; MEDICAL LITERATURE; META ANALYSIS; PAIN; PAIN ASSESSMENT; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; SCORING SYSTEM; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; VISUAL ANALOG SCALE;

EID: 33847121693     PISSN: 14818035     EISSN: 14818035     Source Type: Journal    
DOI: 10.1017/S1481803500014718     Document Type: Article

References (18)

1. Buckley MM, Brogden RN. Ketorolac: a review of its pharmacodynamic and pharmacokenetic properties, and therapeutic potential. Drugs 1990;39:86-109.
2. Wright JM, Price SD, Watson WA. NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. Ann Pharmacother 1994;28:309-12.
3. Turturro MA, Paris PM, Seaberg DC. Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. Ann Emerg Med 1995;26:117-20.
4. Neighbor ML, Puntillo KA. Intramuscular ketorolac vs. oral ibuprofen in emergency department patients with acute pain. Acad Emerg Med 1998;5:118-22.
5. Mixter CG 3rd, Meeker LD, Gavin U. Preemptive pain control in patients having laparoscopic hernia repair: a comparison of ketorolac and ibuprofen. Arch Surg 1998; 133:432-7.
6. Morrison NA, Repka MX. Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus. Ophthalmology 1994;101:915-8.
7. Price DD, Hu JW, Dubner R, et al. Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain 1977;3:57-68.
8. Arendt-Neilson L, Brennum J, Sindrup S, et al. Electrophysical and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol 1994;68:266-73.
9. Guirimand F, Dupont X, Brasseur L, et al. The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. Anesth Analg 2000;90:408-14.
10. Larsen LS, Miller A, Allegra JR. The use of intravenous ketorolac for the treatment of renal colic in the emergency department. Am J Emerg Med 1993;11:197-9.
11. Sandhu DPS, Iacovou JW, Fletcher MS, et al. A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic. Br J Urol 1994;74:690-3.
12. Cordell WH, Wright SW, Wolfson AB, et al. Comparison of intravenous ketorolac, meperidine, and both (balanced analgesia) for renal colic. Ann Emerg Med 1996;28:151-8.
13. Oosterlinck W, Philp NH, Charig C, et al. A double-blind single dose comparison of intramuscular ketorolac tromethamine and pethidine in the treatment of renal colic. J Clin Pharmacol 1990; 30:336-41.
14. Larkin GL, Peacock WF IV, Pearl SM, et al. Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic. Am J Emerg Med 1999;17:6-10.
15. Cohen E, Hafner R, Rotenberg Z, et al. Comparison of ketorolac and diclofenac in the treatment of renal colic. Eur J Clin Pharmacol 1998;54:455-8.
16. Stein A, Ben Dov D, Finkel B, et al. Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic. Am J Emerg Med 1996;14:385-7.
17. Safdar B, Degutis LC, Landry K, et al. Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic. Ann Emerg Med 2006;48:173-81.
18. Schwartz NA, Turturro MA, Istvan DJ, et al. Patients' perceptions of route of nonsteriodal anti-inflammatory drug administration and its effect on analgesia. Acad Emerg Med 2000;7:857-61.