Lymphatic vessel density in pulmonary adenocarcinoma immunohistochemically evaluated with anti-podoplanin or anti-D2-40 antibody is correlated with lymphatic invasion or lymph node metastases

Pathology International

Volumn 57, Issue 4, 2007, Pages 171-177

  Adachi, Yoshin ^a,d   Nakamura, Hiroshige ^b   Kitamura, Yukisato ^a   Taniguchi, Yuji ^b   Araki, Kunio ^c   Shomori, Kohei ^a   Horie, Yasushi ^b   Kurozawa, Youichi ^a   Ito, Hisao ^a   Hayashi, Kazuhiko ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY HOSPITAL   (Japan)

^c National Hospital Organization Matsue National Hospital 5 8 31   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

Author keywords

Lymphatic vessel density; Lymphatic vessel invasion; Pulmonary adenocarcinoma

Indexed keywords

BIOLOGICAL MARKER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D2 40; PODOPLANIN; PROTEIN ANTIBODY; SCATTER FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN C; VASCULOTROPIN D;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER INVASION; CORRELATION ANALYSIS; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LYMPH NODE; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPH VESSEL ENDOTHELIUM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ENDOTHELIUM, LYMPHATIC; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 33847103221     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2007.02077.x     Document Type: Article

References (20)

1. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. Histological Typing of Lung and Pleural Tumors: World Health Organization International Histological Classification of Tumors, 3rd edn. Berlin: Springer, 1999.
2. Otani S, Sato Y, Endo S et al. Prognosis of patients after resection for lung cancer with intrapulmonary metastasis in different lobes. Kyobu Geka 2006; 59: 26-30 (in Japanese).
3. Suzuki K, Nagai K, Yoshida J et al. Conventional clinicopathologic prognostic factors in surgically resected non-small cell lung carcinoma. Cancer 1999; 86: 1976-83.
4. Rigau V, Molina TJ, Chaffaud C et al. Blood vessel invasion in resected non small cell lung carcinomas is predictive of metastatic occurrence. Lung Cancer 2002; 38: 169-76.
5. Takanami I. Lymphatic microvessel density using D2-40 is associated with nodal metastasis in non-small cell lung cancer. Oncol Rep 2006; 15: 437-42.
6. Vermeulen PB, Gasparini G, Fox SB et al. Quantification of angiogenesis in solid tumors: An international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996; 14: 2474-84.
7. Evangelou E, Kyzas PA, Trikalinos TA. Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach. Mod Pathol 2005; 18: 1490-97.
8. Paavonen K, Puolakkainen P, Jussila L et al. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 2000; 156: 1499-504.
9. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press, 2004.
10. Okada K, Osaki M, Araki K, Ishiguro K, Ito H, Ohgi S. Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas. Anticancer Res 2005; 25: 3003-9.
11. Renyi-Vamos F, Tovari J, Fillinger J et al. Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer. Clin Cancer Res 2005; 11: 7344-53.
12. Koukourakis MI, Giatromanolaki A, Sivridis E et al. LYVE-1 immunohistochemical assessment of lymphangiogenesis in endometrial and lung cancer. J Clin Pathol 2005; 58: 202-6.
13. Schacht V, Dadras SS, Johnson LA et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005; 166: 913-21.
14. Okudera K, Kamata Y, Takanashi S et al. Small adenocarcinoma of the lung: Prognostic significance of central fibrosis chiefly because of its association with angiogenesis and lymphangiogenesis. Pathol Int 2006; 56: 494-502.
15. Nakamura Y, Yasuoka H, Zuo H et al. Nitric oxide in papillary thyroid carcinoma: Induction of vascular endothelial growth factor D and correlation with lymph node metastasis. J Clin Endocrinol Metab 2006; 91: 1582-5.
16. Al-Rawi MA, Mansel RE, Jiang WG. Molecular and cellular mechanisms of lymphangiogenesis. Eur J Surg Oncol 2005; 31: 117-21.
17. Schmid K, Birner P, Gravenhorst V, End A, Geleff S. Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung. Am J Surg Pathol 2005; 3: 324-8.
18. Kim SJ, Rabbani ZN, Dewhirst MW et al. Expression of HIF-1, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 2005; 49: 325-35.
19. Wislez M, Rabbe N, Marchal J et al. Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: Role in tumor progression and death. Cancer Res 2003; 63: 1405-12.
20. Hurle RA, Davies G, Parr C et al. Hepatocyte growth factor/scatter factor and prostate cancer: A review. Histol Histopathol 2005; 20: 1339-49.