Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism

Biochemical and Biophysical Research Communications

Volumn 355, Issue 2, 2007, Pages 359-364

  Murphy, Charlotte ^a   Murray, Ann Marie ^a   Meaney, Steve ^a   Gåfvels, Mats ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Atorvastatin; Cholesterol; Cob(I)alamin adenotransferase; Mevalonate kinase; SREBP

Indexed keywords

CHOLESTEROL; COBALAMIN; COBAMAMIDE; ISOPRENOID; MESSENGER RNA; METHYLMALONYL COENZYME A MUTASE; MEVALONATE KINASE; MEVALONIC ACID; SPACER DNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ARTICLE; CHOLESTEROL SYNTHESIS; CHROMOSOME 12; CHROMOSOME 5; ENZYME ACTIVITY; GENE; GENE REPRESSION; HUMAN; HYPERIMMUNOGLOBULINEMIA D AND PERIODIC FEVER SYNDROME; METHYLMALONIC ACIDURIA; MMAB GENE; MVK GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

3T3-L1 CELLS; ANIMALS; BASE SEQUENCE; COBAMIDES; DNA; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE HOMOLOGY, NUCLEIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TERPENES;

MUS;

EID: 33847090730     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.155     Document Type: Article

References (10)

1. Sakakura Y., Shimano H., Sone H., Takahashi A., Inoue N., Toyoshima H., Suzuki S., Yamada N., and Inoue K. Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. Biochem. Biophys. Res. Commun. 286 (2001) 176-183
2. Horton J.D., Shah N.A., Warrington J.A., Anderson N.N., Park S.W., Brown M.S., and Goldstein J.L. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA 100 (2003) 12027-12032
3. Brown M.S., and Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89 (1997) 331-340
4. Murphy C., Ledmyr H., Ehrenborg E., and Gåfvels M. Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y. Biochim. Biophys. Acta 1761 (2006) 1213-1227
5. Murphy C., Parini P., Wang J., Björkhem I., Eggertsen G., and Gåfvels M. Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice. Biochim. Biophys. Acta 1735 (2005) 167-175
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
7. Zanotto E., Shah Z.H., and Jacobs H.T. The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. Nucleic Acids Res. 35 (2007) 664-677
8. Zhang J., Dobson C.M., Wu X., Lerner-Ellis J., Rosenblatt D.S., and Gravel R.A. Impact of cblB mutations on the function of ATP:cob(I)alamin adenosyltransferase in disorders of vitamin B12 metabolism. Mol. Genet. Metab. 87 (2006) 315-322
9. Houten S.M., Frenkel J., Rijkers G.T., Wanders R.J., Kuis W., and Waterham H.R. Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. Hum. Mol. Genet. 11 (2002) 3115-3124
10. Schneiders M.S., Houten S.M., Turkenburg M., Wanders R.J., and Waterham H.R. Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. Arthritis Rheum. 54 (2006) 2306-2313