Effects of morphine on neurosteroidogenesis of primary cultured rat cerebral cortical neurons

Chinese Pharmacological Bulletin

Volumn 22, Issue 12, 2006, Pages 1489-1493

  Jiang, Ping ^a   Hou, Yan Ning ^a  

^a NONE

Author keywords

Morphine; Neuron; Neurosteroid; Opioid receptor; p CREB

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ESTROGEN; MORPHINE; OPIATE AGONIST; PRASTERONE; PREGNENOLONE; PREGNENOLONE SULFATE; STERYL SULFATASE; SULFATE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL LYSATE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; NONHUMAN; RAT; WESTERN BLOTTING;

EID: 33847070045     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Nestler E J, Hyman S E, Malenka R C. Reinforcement and addictive disorders[M]//Nestler E J, Hyman S E, Malenka R C. Molecular Neuropharmacology. Beijing: People's Medical Publishing House, 2001: 355-82.
2. Kawato S, Yamada M, Kimoto T. Brain neurosteroids are 4 th generation neuromessengers in the brain: cell biophysical analysis of steroid signal transduction[J]. Adv Biophys, 2001, 37(1): 1-30.
3. Mellon S H, Griffin L D. Neurosteroids: biochemistry and clinical significance[J]. Trends Endocrinol Metabol, 2002, 13(1): 35-43.
4. Rupprecht R, Holsboer F. Neuroactive steroids: mechanisms of action and neuro-psychopharmacological perspectives [J]. Trends Neurosci, 1999, 22(9): 410-6.
5. Yan C Z, Hou Y N. Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain [J]. Acta Pharmacol Sin, 2004, 25(10): 1285-91.
6. Reddy D S, Kulkarni S K. Chronic neurosteroid treatment prevents the development of morphine torlerance and attenuates abstinence behavior in mice[J]. Euro J Pharmacol, 1997, 337(1): 19-25.
7. Zwain I H, Yen S S C. Neurosteroidogenesis in astrocytes, oligodendrocytes and neurons of cerebral cortex of rat brain[J]. Endocrinology, 1999, 140(8); 3843-52.
8. Zhao L X, Brinton R D. Vasopressin-induced ctoplasmic and nulear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation[J]. J Neurosci, 2003, 23(10): 4228-39.
9. Mensah-Nyagan A G, Do-Rego J L, Beaujean D, et al. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system [J]. Pharmacol Rev, 1999, 51(1): 63-81.
10. Matthes H W, Maldonado R, Simonin F, et al. Loss of morphine-induced analgesia, reward effect and withdrawl symptoms in mice lacking the μ-receptor gene[J]. Nature, 1996, 383(6603): 819-23.
11. Yan C Z, Hou Y N, Li R L, et al. Changes gene expression of steroidogenic enzymes in the brain of the morphine dependence rats [J]. Chin J Anesthesiol, 2005, 25(6): 437-40.
12. Xie Y, Yu Z P, Zhu G X, et al. Mechanisms of morphine evoked changes of intracellular calcium in primary cultured hippocampal neuronal cells[J]. Acta Academiae Med Militaris Tertiae, 2002, 18 (2): 124-7.
13. Liang J H, Pan L S, Zheng J W. cAMP response element combine protein and morphine dependence [J]. Chin J Drug Depend. 2000, 9(3): 161-5.
14. Mellon S H, Griffin L D, Compagnone N A. Biosynthesis and action of neurosteroids[J]. Brain Res Rev, 2001, 37(1): 3-12.
15. Ren J M, Hou Y N. Determination of neurosteroids in rat brain regions by liquid chromatography/negative atmospheric pressure ionization mass spectrometry[J]. Chin J Chromatogr, 2004, 22(6): 575-8.
16. Ren J M, Hou Y N. Determination of unconjugated neurosteroids in rat brain regions by liquid chromatography/negative atmospheric pressure ionization mass spectrometry[J]. Acta Pharm Sin, 2005, 40(3): 262-6.
17. Wolf O T, Kirschbaum C. Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans[J]. Brain Res Rev, 1999, 30(3): 264-88.
18. Baulieu E E, Rebel P. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids [J]. Proc Natl Acad Sci USA, 1998, 95(8): 4089-91.
19. 2 subunit gene expression induced by long-term administration of oral contraceptives in rats[J]. Neuropharmacology, 2002, 42(3): 325-36.
20. Wu H H, Wang N, Hou Y N. Effect of morphine dependence on the levels of neurosteroids and amino acid transmitters in rat nucleus accumbens[J]. Chin Pharmacol Bull, 2005, 21(4): 493-6.