A simple and concise catalytic asymmetric entry to tetrahydroxanthenones

Tetrahedron Letters

Volumn 48, Issue 12, 2007, Pages 2181-2184

  Rios, Ramon ^a   Sundén, Henrik ^a   Ibrahem, Ismail ^a   Córdova, Armando ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE DERIVATIVE; SALICYLALDEHYDE; XANTHONE DERIVATIVE;

ARTICLE; ASYMMETRIC CATALYSIS; ASYMMETRIC SYNTHESIS; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; REACTION ANALYSIS;

EID: 33847068325     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.01.094     Document Type: Article

References (31)

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29. 3CN (1.0 mL) at rt was added α,β-unsaturated ketone 2 (1.2 equiv, 0.30 mmol) and 2-hydroxybenzaldehyde 1 (1.2 equiv, 0.3 mmol). The reaction was vigorously stirred for 72 h and then purified by silica gel chromatography (pentane/EtOAc 20:1) to give the corresponding tetrahydroxanthenone 3.
30. R = 19.6 min).
31. Longer reaction times do not increase the yield of the reaction and decrease the enantioselectivities.