Erectile dysfunction as a risk factor for coronary heart disease: Implications for prevention

International Journal of Clinical Practice

Volumn 61, Issue 2, 2007, Pages 265-268

  Tikkanen, Matti J ^a   Jackson, G ^b   Tammela, T ^c   Assmann, G ^d   Palomaki A ^e   Kupari, M ^a   Olsson, A ^f  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e KANTA HÄME CENTRAL HOSPITAL   (Finland)

^f LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR;

CLINICAL FEATURE; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY RISK; EARLY DIAGNOSIS; ERECTILE DYSFUNCTION; FOLLOW UP; HAZARD ASSESSMENT; HAZARD RATIO; HEART INFARCTION PREVENTION; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LIFESTYLE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREDICTION; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SECONDARY PREVENTION; SITTING;

CORONARY DISEASE; ENDOTHELIUM, VASCULAR; HUMANS; IMPOTENCE, VASCULOGENIC; MALE; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 33847057296     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2006.01271.x     Document Type: Review

References (35)

1. Solomon H, Man JW, Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251-3.
2. Virag R, Bouilly P, Frydman D. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1985; 1: 181-4.
3. Jackson G. Erectile dysfunction and cardiovascular disease. Int J Clin Pract 1999; 53: 363-8.
4. Sullivan ME, Thompson CS, Dashwood MR et al. Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res 1999; 43: 658-65.
5. Kaiser DR, Billups K, Mason C, Wetterling R, Lundberg JL, Bank AJ. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004; 43: 179-84.
6. Montorsi P, Montorsi F, Schulman CC. Is erectile dysfunction the 'tip of the iceberg' of a systemic vascular disorder? Eur Urol 2003; 44: 352-4.
7. Feldman HA, Johannes CB, Derby CA et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Prev Med 2000; 30: 328-38.
8. Rosen MP, Greenfield AJ, Walker TG et al. Cigarette smoking: an independent risk factor for atherosclerosis in the hypogastric-cavernous arterial bed of men with arteriogenic impotence. J Urol 1991; 145: 759-63.
9. Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930-7.
10. Roumeguere T, Wespes E, Carpentier Y, Hoffman P, Schulman CC. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003; 44: 355-9.
11. Fung MM, Bettencourt R, Barrett-Connor E. Heart disease risk factors predict erectile dysfunction 25 years later. J Am Coll Cardiol 2004; 43: 1405-11.
12. Jensen J, Lendorf A, Stimpel H, Frost J, Ibsen H, Rosenkilde K. The prevalence and etiology of impotence in 101 male hypertensive outpatients. Am J Hypertens 1999; 12: 271-5.
13. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61.
14. Bacon CG, Hu FB, Biovannucci E, Glasser DB, Mittleman MA, Rimm EB. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002; 25: 1458-63.
15. Fedele D, Bortolotti A, Coscelli C et al. Erectile dysfunction in type 1 and type 2 diabetics in Italy. Int J Epidemiol 2000; 29: 524-31.
16. Moulik PK, Hardy KJ. Hypertension, antihypertensive drug therapy and erectile dysfunction in diabetes. Diabet Med 2003; 20: 290-3.
17. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 2003; 107: 363-9.
18. Billups KL, Kaiser DR, Kelly AS et al. Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with erectile dysfunction. Int J Impot Res 2003; 15: 231-6.
19. Esposito K, Giugliano F, Martedi E et al. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 2005; 28: 1201-3.
20. Billups KL, Bank AJ, Padma-Nathan H, Katz S, Williams R. Erectile dysfunction is a marker for cardiovascular disease: results of the Minority Health Institute expert advisory panel. J Sex Med 2005; 2: 40-52.
21. Speel TGW, van Langen H, Meuleman EJH. The risk of coronary heart disease in men with erectile dysfunction. Eur Urol 2003; 44: 366-71.
22. Monorsi F, Briganti A, Salonia A et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003; 44: 360-5.
23. Jackson G. Erectile dysfunction, like diabetes, should be considered a 'cardiovascular equivalent'. Int J Clin Pract 2005; 59: 507.
24. Wabrek AJ, Burchell RC. Male sexual dysfunction associated with coronary heart disease. Arch Sex Behav 1980; 9: 69-75.
25. Morley JE, Korenman SG, Kaiser FE, Mooradian AD, Viosca SP. Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men. Am J Med 1988; 84: 445-8.
26. Vlachopoulos C, Rokkas K, Ioakeimidis N et al. Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: a prospective angiographic study. Eur Urol 2005; 48: 996-1003.
27. Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005; 294: 2996-3002.
28. Solomon H, Man J, Wierzbicki AS, O'Brien T, Jackson G. Cardiovascular risk and the role of the cardiologist. Int J Clin Pract 2003; 57: 96-9.
29. The International Task Force for the Prevention of Coronary Heart Disease. Coronary heart disease: reducing the risk. Nutr Metab Cardiovasc Dis 1998; 8: 205-71.
30. De Backer G, Ambrosioni E, Borch-Johnsen K et al. European guidelines on cardiovascular disease prevention in cardiovascular practice. Third Joint Taskforce of European and Other Societies on cardiovascular disease prevention. Eur Heart J 2003; 24: 1601-10.
31. Derby CA, Mohr BA, Goldstein I, Feldman HA, Johannes CB, McKinlay JB. Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 2000; 56: 302-6.
32. Esposito K, Giugliano F, Di Palo C et al. Effect of lifestyle changes on erectile dysfunction in obese men. JAMA 2004; 291: 2978-84.
33. Kostis JB, Jackson G, Rosen R et al. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol 2005; 96: 313-21.
34. Saltzman EA, Guay AT, Jacobson J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation. J Urol 2004; 172: 255-8.
35. Solomon H, Samarasinghe YP, Feher MD et al. Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract 2006; 60: 141-5.