Increased lung expansion alters lung growth but not alveolar epithelial cell differentiation in newborn lambs

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 292, Issue 2, 2007, Pages

  Flecknoe, S J ^a   Crossley, K J ^a   Zuccala, G M ^a   Searle, J E ^a   Allison, B J ^a   Wallace, M J ^a   Hooper, S B ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Alveolar epithelial cells; Lung growth; Lung maturation; Positive end expiratory pressure

Indexed keywords

DNA; MESSENGER RNA; PROTEIN; WATER;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; FETUS LUNG MATURATION; GROWTH RETARDATION; LAMB; LUNG ALVEOLUS EPITHELIUM; LUNG CAPACITY; LUNG DEVELOPMENT; LUNG VENTILATION; LUNG WEIGHT; NEWBORN; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; LUNG; ORGAN SIZE; PHENOTYPE; POSITIVE-PRESSURE RESPIRATION; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEINS; RNA, MESSENGER; SHEEP, DOMESTIC;

EID: 33847034408     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00095.2006     Document Type: Article

References (32)

1. Alcorn D, Adamson TM, Lambert TF, Maloney JE, Ritchie BC, Robinson PM. Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat 123: 649-660, 1977.
2. Alcorn DG, Adamson TM, Maloney JE, Robinson PM. A morphologic and morphometric analysis of fetal lung development in the sheep. Anat Rec 201: 655-667, 1981.
3. Avery ME, Cook CD. Volume-pressure relationships of lungs and thorax in fetal, newborn, and adult goats. J Appl Physiol 16: 1034-1038, 1961.
4. Buhain WJ, Brody JS. Compensatory growth of the lung following pneumonectomy. J Appl Physiol 35: 898-902, 1973.
5. Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 126: 332-337, 1982.
6. Davey MG, Johns DP, Harding R. Postnatal development of respiratory function in lambs studied serially between birth and 8 weeks. Respir Physiol 113: 83-93, 1998.
7. Endl E, Gerdes J. The Ki-67 protein: fascinating forms and an unknown function. Exp Cell Res 257: 231-237, 2000.
8. Flecknoe S, Harding R, Maritz G, Hooper SB. Increased lung expansion alters the proportions of type I and type II alveolar epithelial cells in fetal sheep. Am J Physiol Lung Cell Mol Physiol 278: L1180-L1185, 2000.
9. Flecknoe SJ, Boland RE, Wallace MJ, Harding R, Hooper SB. Regulation of alveolar epithelial cell phenotypes in fetal sheep: roles of cortisol and lung expansion. Am J Physiol Lung Cell Mol Physiol 287: L1207-L1214, 2004.
10. Flecknoe SJ, Wallace MJ, Cock ML, Harding R, Hooper SB. Changes in alveolar epithelial cell proportions during fetal and postnatal development in sheep. Am J Physiol Lung Cell Mol Physiol 285: L664-L670, 2003.
11. Flecknoe SJ, Wallace MJ, Harding R, Hooper SB. Determination of alveolar epithelial cell phenotypes in fetal sheep: evidence for the involvement of basal lung expansion. J Physiol 542: 245-253, 2002.
12. Fuhrman BP, Smith-Wright DL, Kulik TJ, Lock JE. Effects of static and fluctuating airway pressure on intact pulmonary circulation. J Appl Physiol 60: 114-122, 1986.
13. Harding R, Hooper SB. Regulation of lung expansion and lung growth before birth. J Appl Physiol 81: 209-224, 1996.
14. Harding R, Johnson P, McClelland ME. Respiratory function of the larynx in developing sheep and the influence of sleep state. Respir Physiol 40: 165-179, 1980.
15. Harding R, Liggins GC. Changes in thoracic dimensions induced by breathing movements in fetal sheep. Reprod Fertil Dev 8: 117-124, 1996.
16. Hooper SB, Han VKM, Harding R. Changes in lung expansion alter pulmonary DNA synthesis and IGF-II gene expression in fetal sheep. Am J Physiol Lung Cell Mol Physiol 265: L403-L409, 1993.
17. Hooper SB, Harding R. Fetal lung liquid: a major determinant of the growth and functional development of the fetal lung. Clin Exp Pharmacol Physiol 22: 235-247, 1995.
18. Lines A, Nardo L, Phillips ID, Possmayer F, Hooper SB. Alterations in lung expansion affect surfactant protein A, B, and C mRNA levels in fetal sheep. Am J Physiol Lung Cell Mol Physiol 276: L239-L245, 1999.
19. Lines AL, Davey MG, Harding R, Hooper SB. Effect of increased lung expansion on surfactant protein mRNA levels in lambs. Pediatr Res 50: 720-725, 2001.
20. Moessinger AC, Harding R, Adamson TM, Singh M, Kiu GT. Role of lung fluid volume in growth and maturation of the fetal sheep lung. J Clin Invest 86: 1270-1277, 1990.
21. Nakamura T, Liu M, Mourgeon E, Slutsky A, Post M. Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression. Am J Physiol Lung Cell Mol Physiol 278: L974-L980, 2000.
22. Nardo L, Hooper SB, Harding R. Stimulation of lung growth by tracheal obstruction in fetal sheep: relation to luminal pressure and lung liquid volume. Pediatr Res 43: 184-190, 1998.
23. Nardo L, Maritz G, Harding R, Hooper SB. Changes in lung structure and cellular division induced by tracheal obstruction in fetal sheep. Exp Lung Res 26: 105-119, 2000.
24. Pasternack M Jr, Liu X, Goodman RA, Rannels DE. Regulated stimulation of epithelial cell DNA synthesis by fibroblast-derived mediators. Am J Physiol Lung Cell Mol Physiol 272: L619-L630, 1997.
25. Polglase GR, Morley CJ, Crossley KJ, Dargaville P, Harding R, Morgan DL, Hooper SB. Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol 99: 1453-1461, 2005.
26. Probyn ME, Hooper SB, Dargaville PA, McCallion N, Crossley K, Harding R, Morley CJ. Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure. Pediatr Res 56: 198-204, 2004.
27. Rannels DE. Role of physical forces in compensatory growth of the lung. Am J Physiol Lung Cell Mol Physiol 257: L179-L189, 1989.
28. Rannels DE, Rannels SR. Compensatory growth of the lung following partial pneumonectomy. Exp Lung Res 14: 157-182, 1988.
29. Rannels DE, White DM, Watkins CA. Rapidity of compensatory lung growth following pneumnoectomy in adult rats. J Appl Physiol 46: 326-333, 1979.
30. Watkins CA, Burkhart LR, Rannels DE. Lung growth in response to unilateral pneumonectomy in rapidly growing rats. Am J Physiol Endocrinol Metab 248: E162-E169, 1985.
31. Woods E, Ohashi T, Polk D, Ikegami M, Ueda T, Jobe AH. Surfactant treatment and ventilation effects on surfactant SP-A, SP-B, and SP-C mRNA levels in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol 269: L209-L214, 1995.
32. Zhang S, Garbutt V, McBride JT. Strain-induced growth of the immature lung. J Appl Physiol 81: 1471-1476, 1996.