Tendon healing in vitro: Adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not

Plastic and Reconstructive Surgery

Volumn 119, Issue 1, 2007, Pages 227-234

  Wang, Xiao Tian ^b   Liu, Paul Y ^b   Tang, Jin Bo ^a   Mizukami, Hiroaki ^b   Xin, Ke Qin ^b   Ozawa, Keiya ^b   Ushijima, Hiroshi ^b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; PARVOVIRUS VECTOR; PLASMID VECTOR; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2;

ANIMAL CELL CULTURE; ARTICLE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CYTOMEGALOVIRUS; EMBRYO; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTYPE; STATISTICAL ANALYSIS; TENDON INJURY; TENOCYTE; TRANSGENE; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WOUND HEALING; ADENOVIRUS; ANIMAL; CELL CULTURE; CLASSIFICATION; CYTOLOGY; GENETICS; SPRAGUE DAWLEY RAT; TENDON;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; RATS; RATS, SPRAGUE-DAWLEY; TENDONS; TRANSDUCTION, GENETIC; TRANSGENES; WOUND HEALING;

EID: 33847033417     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000244861.57040.3f     Document Type: Article

References (36)

1. Chow, J. A., Thomes, L. J., Dovelle, S., Milnor, W. H., Seyfer, A. E., and Smith, A. C. A combined regimen of controlled motion following flexor tendon repair in "no man's land." Plast. Reconstr. Surg. 79: 447, 1987.
2. Savage, R., and Risitano, G. Flexor tendon repair using a "six strand" method of repair and early active mobilization. J. Hand Surg. (Br.) 14: 396, 1989.
3. Tang, J. B., Gu, Y. T., Rice, K., Chen, F., and Pan, C. Z. Evaluation of four methods of flexor tendon repair for postoperative active mobilization. Plast. Reconstr. Surg. 107: 742, 2001.
4. Mass, D. P., and Tuel, R. Human flexor tendon participation in the in vitro repair process. J. Hand Surg. (Am.) 14: 64, 1989.
5. Chan, B. P., Fu, S., Qin, L., Lee, K., Rolf, C. G., and Chan, K. Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: A rat patellar tendon model. Acta Orthop. Scand. 71: 513, 2000.
6. Lou, J., Manske, P. R., Aoki, M., and Joyce, M. E. Adenovirus-mediated gene transfer into tendon and tendon sheath. J. Orthop. Res. 14: 513, 1996.
7. Lou, J., Kubota, H., Hotokezaka, S., Ludwig, F. J., and Manske, P. R. In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change. J. Orthop. Res. 15: 911, 1997.
8. Lou, J., Tu, Y., Burns, M., Silva, M. J., and Manske, P. R. BMP-12 gene transfer augmentation of lacerated tendon repair. J. Orthop. Res. 19: 1199, 2001.
9. Wang, X. T., Liu, P. Y., and Tang, J. B. Tendon healing in vitro: Genetic modification of tenocytes with exogenous PDGF gene and promotion of collagen gene expression. J. Hand Surg. (Am.) 29: 884, 2004.
10. Brenner, M. Gene transfer by adenovectors. Blood 94: 3965, 1999.
11. Chandler, L. A., and Sosnowski, B. A. Gene therapy for cutaneous wound repair. Wounds 16: 23, 2004.
12. McMahon, J. M., Wells, K. E., Bamfo, J. E., Cartwright, M. A., and Wells, D. J. Inflammatory responses following direct injection of plasmid DNA into skeletal muscle. Gene Ther. 5: 1283, 1998.
13. Nidome, T., and Huang, L. Gene therapy progress and prospects: Nonviral vectors. Gene Ther. 9: 1647, 2002.
14. Schwarz, E. M. The adeno-associated virus vector for orthopedic gene therapy. Clin. Orthop. 379S: 31, 2000.
15. Lai, C. M., Lai, Y. K., and Rakoczy, P. E. Adenovirus and adeno-associated virus vectors. DNA Cell Biol. 21: 895, 2002.
16. Yokoo, N., Saito, T., Uesugi, M., et al. Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum. 52: 164, 2005.
17. Wang, X. T., Liu, P. Y., and Tang, J. B. PDGF gene therapy enhances expression of VEGF and bFGF genes and activates NF-kB gene in signal pathways in ischemic flaps. Plast. Reconstr. Surg. 117: 129, 2006.
18. Chan, B. P., Chan, K. M., Maffulli, N., Webb, S., and Lee, K. H. Effect of basic fibroblast growth factor: An in vitro study of tendon healing. Clin. Orthop. 342: 239, 1997.
19. Abrahamsson, S. O. Similar effects of recombinant human insulin-like growth factor-I and II on cellular activities in flexor tendons of young rabbits: Experimental studies in vitro. J. Orthop. Res. 15: 256, 1997.
20. Tang, J. B., Xu, Y., Ding, F., and Wang, X. T. Tendon healing in vitro: Promotion of collagen gene expression by bFGF with NF-kB gene activation. J. Hand Surg. (Am.) 28: 215, 2003.
21. Klein, M. B., Yalamanchi, N., Pham, H., Longaker, M. T., and Chang, J. Flexor tendon healing in vitro: Effects of TGF- on tendon cell collagen production. J. Hand Surg. (Am.) 27: 615, 2002.
22. Xiao, W., Chirmule, N., Berta, S. C., McCullough, B., Gao, G., and Wilson, J. M. Gene therapy vectors based on adeno-associated virus type 1. J. Virol. 73: 3994, 1999.
23. Auricchio, A., Kobinger, G., Anand, V., et al. Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: The retina as a model. Hum. Mol. Genet. 10: 3075, 2001.
24. Davidson, B. L., Stein, C. S., Heth, J. A., et al. Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system. Proc. Natl. Acad. Sci. U.S.A. 97: 3428, 2000.
25. Louboutin, J. P., Wang, L., and Wilson, J. M. Gene transfer into skeletal muscle using novel AAV serotypes. J. Gene Med. 7: 442, 2005.
26. Gao, G. P., Alvira, M. R., Wang, L., Calcedo, R., Johnston, J., and Wilson, J. M. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. U.S.A. 99: 11854, 2002.
27. Vinther, M. U., Duch, M. R., O'Keefe R. J., Schwarz, E. M., and Pedersen, F. S. In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J. Orthop. Res. 22: 726, 2004.
28. Pajusola, K., Gruchala, M., Joch, H., Luscher, T. F., Yla-Herttuala, S., and Bueler, H. Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells. J. Virol. 76: 11530, 2002.
29. Tang, J. B., Xu, Y., and Wang, X. T. Tendon healing in vitro: Activation of NIK, IIKα, IKKβ and NF-κB genes in signal pathway and proliferation of tenocytes. Plast. Reconstr. Surg. 113: 1703, 2004.
30. Small, J. O., Brennen, M. D., and Colville, J. Early active mobilization following flexor tendon repair in zone 2. J. Hand Surg. (Br.) 14: 383, 1989.
31. Cullen, K. W., Tolhurst, P., Lang, D., and Page, R. E. Flexor tendon repair in zone 2 followed by controlled active mobilization. J. Hand Surg. (Br.) 14: 392, 1989.
32. Elliot, D., Moiemen, N. S., Flemming, A. F. S., Harris, S. B., and Foster, A. J. The rupture rate of acute flexor tendon repairs mobilized by the controlled active motion regimen. J. Hand Surg. (Br.) 19: 607, 1994.
33. Kitsis, C. K., Wade, P. J. F., Krikler, S. J., Parsons, N. K., and Nicholls, L. K. Controlled active motion following primary flexor tendon repair: A prospective study over 9 years. J. Hand Surg. (Br). 23: 344, 1998.
34. Harris, S. B., Harris, D., Foster, A. J., and Elliot, D. The aetiology of acute rupture of flexor tendon repairs in zones 1 and 2 of the fingers during early mobilization. J. Hand Surg. (Br.) 24: 275, 1999.
35. Boyer, M. I. Flexor tendon biology. Hand Clin. 21: 159, 2005.
36. Tang, J. B. Clinical outcomes associated with flexor tendon repair. Hand Clin. 21: 199, 2005.