Formulation and evaluation of ketorolac transdermal systems

Drug Delivery

Volumn 14, Issue 2, 2007, Pages 69-74

  Choi, Jun Shik ^a   Cho, Young Ah ^a   Chun, In Koo ^b   Jung, Sun Young ^c   Gwak, Hye Sun ^c  

^a Chosun University   (South Korea)

^b Dongduk Women's University   (South Korea)

^c Ewha Womans University   (South Korea)

Author keywords

Ketorolac Transdermal Systems; Pharmacokinetics; Pressure Sensitive Adhesives; Vehicles

Indexed keywords

ACRYLIC CEMENT; ADHESIVE AGENT; CAPRYOL; DIETHYLENE GLYCOL MONOETHYL ETHER; DURO TAK; KETOROLAC TROMETAMOL; LAUROGLYCOL; METHANOL; PROPYLENE GLYCOL; PROPYLENE GLYCOL CAPRYLATE; PROPYLENE GLYCOL LAURATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSDERMAL DRUG ADMINISTRATION;

ADHESIVES; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; DRUG STABILITY; HALF-LIFE; KETOROLAC; MALE; MICE; MICE, INBRED HRS; PHARMACEUTICAL SOLUTIONS; PRESSURE; PROPYLENE GLYCOL; RATS; RATS, SPRAGUE-DAWLEY; VEHICLES;

EID: 33847029891     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540600640336     Document Type: Article

References (18)

1. Aungst, B. J., Rogers, N. J., and Shefter, E. 1986. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides. Int. J. Pharm. 33: 225-234.
2. Barry, B. W. 1983. Dermatological Formulations. New York: Marcel Dekker, 49-94.
3. Buckley, M. M., and Brogden, R. N. 1990. Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 39:86-109.
4. Cho Y. A., and Gwak, H. S. 2004. Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. Drug Dev. Ind. Pharm. 30:557-564.
5. Cho, Y. J., and Choi, H. K. 1998. Enhancement of percutaneous absorption of ketoprofen: effect of vehicles and adhesive matrix. Int. J. Pharm. 169:95-104.
6. Cooper, E. R. 1984. Increased skin permeability for lipophilic molecules. J. Pharm. Sci. 73:153-1156.
7. Cooper, E. R., Merritt, E. W., and Smith, R. L. 1985. Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro. J. Pharm. Sci. 74:688-689.
8. Forbes, J. A., Butterworth, G. A., Burchfield, W. H., and Beaver, A. T. 1990. Evaluation of ketorolac, aspirin and acetaminophen-codeine combination in postoperative oral surgery pain. Pharmacotherapy 10:77S-93S.
9. Grandos-Soto, V., Lopez-Munoz, F. J., Hong, E., and Fluores-Murrieta, F. J. 1995. Relationship between pharmacokinetics and the analgesic effect of ketorolac in the rat. J. Pharmacol. Exp. Ther. 272:352-356.
10. Nomura, H., Fusao, K., Sugimoto, Y., Miyashita, Y., Dohi, M., and Kato, Y. 1990. Percutaneous absorption of indomethacin from mixtures of fatty alcohol and propylene glycol (FAPG bases) through rat skin: effects of oleic acid added to FAPG base. Chem. Pharm. Bull. 38:1421-1424.
11. O'Hara, D. A., Fragen, R. J., Kinzer, M., and Pemberton, D. 1987. Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain. Clin. Pharmacol. Ther. 41:556-561.
12. Pasloske, K., Renaud, R., Burger, J., and Conlon, P. 1999. Pharmacokinetics of ketorolac after intravenous and oral single dose administration in dogs. J. Vet. Pharmacol. Ther. 22:314-319.
13. Reinhart, D. I. 2000. Minimizing the adverse effects of ketorolac. Drug Safety 22:487-497.
14. Rooks, W. H., Maloney, P. J., Shott, L. D., Schuler, M. E., Sevelius, H., Strosberg, A. M., Tanenbaum, L., et al. 1985. The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt. Drugs Exp. Clin. Res. 11:479-492.
15. Stanski, D. R., Cherry, C., Bradley, R., Sarnquist, F. H., and Yee, J. P. 1990. Efficacy and safety of single doses of intramuscular ketorolac tromethamine compared with meperidine for postoperative pain. Pharmacotherapy 10:40S-44S.
16. Tiwari, S. B., and Udupa, N. 2003. Investigation into the potential of iontophoresis facilitated delivery of ketorolac. Int. J. Pharm. 260:93-103.
17. Yamada, M., Uda, Y., and Tanigawara, Y. 1987. Mechanism of enhancement of percutaneous absorption of molsidomine by oleic acid. Chem. Pharm. Bull. 35:3399-3406.
18. Yee, J. P., Koshiver, J. V., Allbon, C., and Brown, C. R. 1986. Comparison of intramuscular ketorolac tromethamine and morphine sulfate for analgesia of pain after major surgery. Pharmacotherapy 6:253-261.