Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers

Journal of Endocrinological Investigation

Volumn 29, Issue 11, 2006, Pages

  Leggio, G M ^a   Incognito, T ^a   Privitera, G ^a   Marano, M R ^a   Drago, F ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Bioavailability; Formula; Levothyroxine; Lioequivalence; Liothyronine

Indexed keywords

LEVOTHYROXINE SODIUM; LIOTHYRONINE; LIOTHYRONINE SODIUM; THYROXINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CHEMOLUMINESCENCE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; ELECTROCHEMICAL ANALYSIS; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; ORAL DROPS; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TABLET; BIOAVAILABILITY; BLOOD; MIDDLE AGED; ORAL DRUG ADMINISTRATION; SOLUTION AND SOLUBILITY;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; HUMANS; MALE; MIDDLE AGED; SOLUTIONS; TABLETS; THYROXINE; TRIIODOTHYRONINE;

EID: 33847006278     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03349205     Document Type: Article

References (7)

1. Nygaard B. Primary hypothyroidism. Clin Evid 2003, 10:715-20 Update in: Clin Evid 2004, 12: 898-903.
2. Escobar-Morreale HF, Obregon MJ, Escobar del Rey F, Morreale de Escobar G. Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J Clin Invest 1995, 96:2828-38.
3. Escobar-Morreale HF, del Rey FE, Obregon MJ, de Escobar GM. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology. 1996, 137: 2490-502.
4. Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ Jr. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999, 340: 424-9.
5. Wiersinga WM. Thyroid hormone replacement therapy. Horm Res 2001, 56 (Suppl. 1): 74-81.
6. Westlake WJ. Use of confidence intervals in analysis of comparative bioavailability trials. J Pharm Sci 1972: 61: 1340-1.
7. Meier CA, Maisey MN, Lowry A, Muller J, Smith MA. Interindividual differences in the pituitary-thyroid axis influence the interpretation of thyroid function test. Clin Endocrinol (Oxf) 1993, 39: 101-7.