Hypoglycaemia-insulin test: Discordant growth hormone and cortisol response in paediatric patients regarding recovery from hypoglycaemia with or without oral glucose solution

Hormone Research

Volumn 67, Issue 1, 2007, Pages 42-45

  Yeste, Diego ^a,b   Tomasini, Rosangela ^a   Dodino, Gabriela ^a   Gussinyé, Miquel ^a   Potau, Neus ^a   Carrascosa, Antonio ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL MATERNO INFANTIL VALL D HEBRON   (Spain)

Author keywords

Adolescents; Children; Growth hormone deficiency; Hypoglycaemia insulin test

Indexed keywords

GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; NEUTRAL INSULIN; SOMATOMEDIN C;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE RESPONSE; HUMAN; HYPOGLYCEMIA; HYPOGLYCEMIA INSULIN TEST; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SCHOOL CHILD; STATISTICAL SIGNIFICANCE; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ANTHROPOMETRY; CASE-CONTROL STUDIES; CHILD; FEMALE; GLUCOSE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; MALE; PITUITARY FUNCTION TESTS; PUBERTY; STIMULATION, CHEMICAL;

EID: 33846999339     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096055     Document Type: Article

References (11)

1. Shah A, Stanhope R, Matthew D: Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ 1992;304:173-174.
2. Ranke MB: Diagnosis of growth hormone deficiency and growth hormone stimulation tests; in Ranke MB (ed): Diagnostics of Endocrine Function in Children and Adolescents, ed 3. Basel, Karger, 2003, pp 107-128.
3. Galloway PJ, McNeill E, Paterson WF, Donaldson MD: Safety of the insulin tolerance test. Arch Dis Child 2002;87:354-356.
4. Borm K, Slawick M, Beuschlein F, Seiler L, Flohr F, Berg A, Koenig A, Reincke M: Low-dose glucose infusion after achieving critical hypoglycaemia during insulin tolerance testing: effects on time of hypoglycaemia, neuroendocrine stress response and patient's discomfort in a pilot study. Eur J Endocrinol 2005;153:521-526.
5. Page MD, Koppeschaar HP, Edwards CA, Dieguez C, Scanlon MF: Additive effects of growth hormone releasing factor and insulin hypoglycaemia on growth hormone release in man. Clin Endocrinol (Oxf) 1987;26:589-595.
6. Hindmarsh PC, Brook CG: Short stature and growth hormone deficiency. Clin Endocrinol 1995;43:133-142.
7. Hussain K, Hindmarsh P, Aynsley-Green A: Spontaneous hypoglycemia in childhood is accompanied by paradoxically low serum growth hormone and appropriate cortisol counter regulatory hormonal responses. J Clin Endocrinol Metab 2003;88:3715-3723.
8. West TE, Sonksen PH: Is the growth-hormone response to insulin due to hypoglycaemia, hyperinsulinaemia or a fall in plasma free fatty acids? Clin Endocrinol (Oxf) 1977;7:283-288.
9. Page MD, Koppeschaar HP, Edwards CA, Dieguez C, Scanlon MF: Additive effects of growth hormone releasing factor and insulin hypoglycaemia on growth hormone release in man. Clin Endocrinol (Oxf) 1987;26:589-595.
10. Berelowitz M, Dudlak D, Frohman LA: Release of somatostatin-like immunoreactivity from incubated rat hypothalamus and cerebral cortex. Effects of glucose and glucoregulatory hormones. J Clin Invest 1982;69:1293-1301.
11. Broglio F, Gottero C, Prodam F, Destefanis S, Gauna C, Me E, Riganti F, Vivenza D, Rapa A, Martina V, Arvat E, Bona G, van der Lely AJ, Ghigo E: Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clin Endocrinol (Oxf) 2004;61:503-509.