메뉴 건너뛰기




Volumn 97, Issue 1, 2007, Pages 32-37

No interaction between factor V Leiden and hyperhomocysteinemia of MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study

Author keywords

Case control; Case only; Factor V Leiden; Homocysteine; Meta analysis; Methylenetetrahydrofolatereductase; MTHFR; VITRO

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5 LEIDEN; HOMOCYSTEINE;

EID: 33846976525     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-09-0486     Document Type: Article
Times cited : (27)

References (41)
  • 1
    • 0033519051 scopus 로고    scopus 로고
    • Venous thrombosis: A multicausal disease
    • Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999; 353: 1167-73.
    • (1999) Lancet , vol.353 , pp. 1167-1173
    • Rosendaal, F.R.1
  • 3
    • 0028000665 scopus 로고
    • Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families
    • Koeleman BPC, Reitsma PH, Allaart CF, et al. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
    • (1994) Blood , vol.84 , pp. 1031-1035
    • Koeleman, B.P.C.1    Reitsma, P.H.2    Allaart, C.F.3
  • 4
    • 0029016883 scopus 로고
    • Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S
    • Zöller B, Berntsdotter A, de Frutos PG, et al. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood 1995; 85: 3518-23.
    • (1995) Blood , vol.85 , pp. 3518-3523
    • Zöller, B.1    Berntsdotter, A.2    de Frutos, P.G.3
  • 5
    • 0028291210 scopus 로고
    • Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis
    • Zöller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994; 343: 1536-8.
    • (1994) Lancet , vol.343 , pp. 1536-1538
    • Zöller, B.1    Dahlbäck, B.2
  • 6
    • 0028314865 scopus 로고
    • Mutation in blood coagulation factor V associated with resistance to activated protein C
    • Bertina RM, Koeleman BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    • (1994) Nature , vol.369 , pp. 64-67
    • Bertina, R.M.1    Koeleman, B.P.C.2    Koster, T.3
  • 7
    • 20444445722 scopus 로고    scopus 로고
    • Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies
    • den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3: 292-9.
    • (2005) J Thromb Haemost , vol.3 , pp. 292-299
    • den Heijer, M.1    Lewington, S.2    Clarke, R.3
  • 8
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 9
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 10
    • 0037322022 scopus 로고    scopus 로고
    • 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Smith GD, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003; 32: 1-22.
    • (2003) Int J Epidemiol , vol.32 , pp. 1-22
    • Smith, G.D.1    Ebrahim, S.2
  • 11
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 2002; 325: 1202-8.
    • (2002) Br Med J , vol.325 , pp. 1202-1208
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 12
    • 0037633079 scopus 로고    scopus 로고
    • Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: Meta-analysis of 31 studies
    • Ray JG, Shmorgun D, Chan WS. Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: Meta-analysis of 31 studies. Pathophysiol Haemost Thromb 2002; 32: 51-8.
    • (2002) Pathophysiol Haemost Thromb , vol.32 , pp. 51-58
    • Ray, J.G.1    Shmorgun, D.2    Chan, W.S.3
  • 13
    • 0035830874 scopus 로고    scopus 로고
    • Homocysteine inhibits inactivation of factor Va by activated protein C
    • Undas A, Williams EB, Butenas S, et al. Homocysteine inhibits inactivation of factor Va by activated protein C. J Biol Chem 2001; 276: 4389-97.
    • (2001) J Biol Chem , vol.276 , pp. 4389-4397
    • Undas, A.1    Williams, E.B.2    Butenas, S.3
  • 14
    • 0036845561 scopus 로고    scopus 로고
    • Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis
    • Keijzer MBAJ, den Heijer M, Blom HJ, et al. Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis. Thromb Haemost 2002; 88: 723-8.
    • (2002) Thromb Haemost , vol.88 , pp. 723-728
    • Keijzer, M.B.A.J.1    den Heijer, M.2    Blom, H.J.3
  • 15
    • 0029921114 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
    • den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334: 759-62.
    • (1996) N Engl J Med , vol.334 , pp. 759-762
    • den Heijer, M.1    Koster, T.2    Blom, H.J.3
  • 16
    • 0030953866 scopus 로고    scopus 로고
    • Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    • Ridker PM, Hennekens CH, Selhub J, et al. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 1997; 95: 1777-82.
    • (1997) Circulation , vol.95 , pp. 1777-1782
    • Ridker, P.M.1    Hennekens, C.H.2    Selhub, J.3
  • 17
    • 0032824284 scopus 로고    scopus 로고
    • Prevalence of mild hyperhomocysteinaemia and association with thrombophilic genotypes (factor V Leiden and prothrombin G20210A) in Italian patients with venous thromboembolic disease
    • De Stefano V, Zappacosta B, Persichilli S, et al. Prevalence of mild hyperhomocysteinaemia and association with thrombophilic genotypes (factor V Leiden and prothrombin G20210A) in Italian patients with venous thromboembolic disease. Br J Haematol 1999; 106: 564-8.
    • (1999) Br J Haematol , vol.106 , pp. 564-568
    • De Stefano, V.1    Zappacosta, B.2    Persichilli, S.3
  • 18
    • 0037373178 scopus 로고    scopus 로고
    • Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)
    • Tsai AW, Cushman M, Tsai MY, et al. Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Hematol 2003; 72: 192-200.
    • (2003) Am J Hematol , vol.72 , pp. 192-200
    • Tsai, A.W.1    Cushman, M.2    Tsai, M.Y.3
  • 19
    • 0033017739 scopus 로고    scopus 로고
    • Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism. Prevalence and risk assessment
    • Salomon O, Steinberg DM, Zivelin A, et al. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism. Prevalence and risk assessment. Arterioscler Thromb Vase Biol 1999; 19: 511-8.
    • (1999) Arterioscler Thromb Vase Biol , vol.19 , pp. 511-518
    • Salomon, O.1    Steinberg, D.M.2    Zivelin, A.3
  • 20
    • 0032897895 scopus 로고    scopus 로고
    • The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: Prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels
    • Cattaneo M, Chantarangkul V, Taioli E, et al. The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: Prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels. Thromb Res 1999; 93: 1-8.
    • (1999) Thromb Res , vol.93 , pp. 1-8
    • Cattaneo, M.1    Chantarangkul, V.2    Taioli, E.3
  • 21
    • 0037101569 scopus 로고    scopus 로고
    • CBS 844ins68, MTHFR TT677 and EPCR 4031ins23 genotypes in patients with deep-vein thrombosis
    • Grossmann R, Schwender S, Geisen U, et al. CBS 844ins68, MTHFR TT677 and EPCR 4031ins23 genotypes in patients with deep-vein thrombosis. Thromb Res 2002; 107: 13-5.
    • (2002) Thromb Res , vol.107 , pp. 13-15
    • Grossmann, R.1    Schwender, S.2    Geisen, U.3
  • 22
    • 0031713550 scopus 로고    scopus 로고
    • Effect of the MTHFRC677T variant on risk of venous thromboembolism: Interaction with factor V Leiden and prothrombin (F2G20210A) mutations
    • Brown K, Luddington R, Baglin T. Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations. Br J Haematol 1998; 103: 42-4.
    • (1998) Br J Haematol , vol.103 , pp. 42-44
    • Brown, K.1    Luddington, R.2    Baglin, T.3
  • 23
    • 0031886677 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis
    • Kluijtmans LAJ, den Heijer M, Reitsma PH, et al. Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thromb Haemost 1998; 79: 254-8.
    • (1998) Thromb Haemost , vol.79 , pp. 254-258
    • Kluijtmans, L.A.J.1    den Heijer, M.2    Reitsma, P.H.3
  • 25
    • 0032946114 scopus 로고    scopus 로고
    • Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes
    • Alhenc-Gelas M, Arnaud E, Nicaud V, et al. Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes. Thromb Haemost 1999; 81: 506-10.
    • (1999) Thromb Haemost , vol.81 , pp. 506-510
    • Alhenc-Gelas, M.1    Arnaud, E.2    Nicaud, V.3
  • 26
    • 0032532387 scopus 로고    scopus 로고
    • Search for genetic factors favoring thrombosis in Turkish population
    • Akar N, Akar E, Misirlioglu M, et al. Search for genetic factors favoring thrombosis in Turkish population. Thromb Res 1998; 92: 79-82.
    • (1998) Thromb Res , vol.92 , pp. 79-82
    • Akar, N.1    Akar, E.2    Misirlioglu, M.3
  • 27
    • 0033621632 scopus 로고    scopus 로고
    • Effect of metylene-tetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients
    • Akar N, Akar E, Akçay R, et al. Effect of metylene-tetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res 2000; 97: 163-7.
    • (2000) Thromb Res , vol.97 , pp. 163-167
    • Akar, N.1    Akar, E.2    Akçay, R.3
  • 28
    • 0035212425 scopus 로고    scopus 로고
    • Comparative prevalence of antiphospholipid antibodies and thrombophilic genotypes in consecutive patients with venous thrombosis
    • Cappucci G, Margaglione M, Ames PRJ. Comparative prevalence of antiphospholipid antibodies and thrombophilic genotypes in consecutive patients with venous thrombosis. Blood Coagul fibrinolysis 2001; 12: 659-65.
    • (2001) Blood Coagul Fibrinolysis , vol.12 , pp. 659-665
    • Cappucci, G.1    Margaglione, M.2    Ames, P.R.J.3
  • 30
    • 0035606959 scopus 로고    scopus 로고
    • Major and potential prothrombotic genotypes in a cohort of patients with venous thromboembolism
    • Iglesias Varela ML, Adamczuk YP, Forastiero RR, et al. Major and potential prothrombotic genotypes in a cohort of patients with venous thromboembolism. Thromb Res 2001; 104: 317-24.
    • (2001) Thromb Res , vol.104 , pp. 317-324
    • Iglesias Varela, M.L.1    Adamczuk, Y.P.2    Forastiero, R.R.3
  • 31
    • 33845964945 scopus 로고    scopus 로고
    • Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism. A randomised, placebo-controlled, double blind trial
    • September 7, doi:10.1182/blood-2006-04-014654
    • den Heijer M, Willems H, Blom H, et al. Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism. A randomised, placebo-controlled, double blind trial. Blood September 7, 2006; doi:10.1182/blood-2006-04-014654.
    • (2006) Blood
    • den Heijer, M.1    Willems, H.2    Blom, H.3
  • 32
    • 0031934810 scopus 로고    scopus 로고
    • Acidic citrate stabilizes blood samples for assay of total homocysteine
    • Willems HPJ, Bos GMJ, Gerrits WBJ, et al. Acidic citrate stabilizes blood samples for assay of total homocysteine. Clin Chem 1998; 44: 3425.
    • (1998) Clin Chem , vol.44 , pp. 3425
    • Willems, H.P.J.1    Bos, G.M.J.2    Gerrits, W.B.J.3
  • 33
    • 0028913608 scopus 로고
    • Three different methods for the determination of total homocysteine in plasma
    • Te Poele-Pothoff MT, van den Berg M, Franken DG, et al. Three different methods for the determination of total homocysteine in plasma. Ann Clin Biochem 1995; 32: 218-20.
    • (1995) Ann Clin Biochem , vol.32 , pp. 218-220
    • Te Poele-Pothoff, M.T.1    van den Berg, M.2    Franken, D.G.3
  • 34
    • 0026702157 scopus 로고
    • Confidence Interval estimation of interaction
    • Hosmer DW. Lemeshow S. Confidence Interval estimation of interaction. Epidemiology 1992; 5: 452-6.
    • (1992) Epidemiology , vol.5 , pp. 452-456
    • Hosmer, D.W.1    Lemeshow, S.2
  • 35
    • 3042536588 scopus 로고    scopus 로고
    • Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability
    • Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability. Thromb Haemost 2004; 91: 1115-22.
    • (2004) Thromb Haemost , vol.91 , pp. 1115-1122
    • Zarychanski, R.1    Houston, D.S.2
  • 36
    • 23744444704 scopus 로고    scopus 로고
    • Interaction: A word with two meanings creates confusion
    • Ahlbom A, Alfredsson L. Interaction: A word with two meanings creates confusion. Fur J Epidemiol 2005; 20: 563-4.
    • (2005) Eur J Epidemiol , vol.20 , pp. 563-564
    • Ahlbom, A.1    Alfredsson, L.2
  • 37
    • 0029933176 scopus 로고    scopus 로고
    • Coexistence of hereditary homocystinuria and factor V Leiden-effect on thrombosis
    • Mandel H, Brenner B, Berant M, et al. Coexistence of hereditary homocystinuria and factor V Leiden-effect on thrombosis. New Engl J Med 1996; 334: 763-8.
    • (1996) New Engl J Med , vol.334 , pp. 763-768
    • Mandel, H.1    Brenner, B.2    Berant, M.3
  • 38
    • 0034919919 scopus 로고    scopus 로고
    • Factor V Leiden mutation in Turkish patients with homozygous cystathionine β-synthase deficiency
    • Kalkanoǧlu HS, Coşkun T, Aydoǧdu SD, et al. Factor V Leiden mutation in Turkish patients with homozygous cystathionine β-synthase deficiency. J Inherit Metab Dis 2001; 24: 367-9.
    • (2001) J Inherit Metab Dis , vol.24 , pp. 367-369
    • Kalkanoǧlu, H.S.1    Coşkun, T.2    Aydoǧdu, S.D.3
  • 39
    • 0029971051 scopus 로고    scopus 로고
    • Thrombophilia, homocystinuria, and mutation of the factor V gene
    • Quere I, Lamarti H, Chadefaux-Vekemans B. Thrombophilia, homocystinuria, and mutation of the factor V gene. New Engl J Med 1996; 335: 289-90.
    • (1996) New Engl J Med , vol.335 , pp. 289-290
    • Quere, I.1    Lamarti, H.2    Chadefaux-Vekemans, B.3
  • 40
    • 0032521543 scopus 로고    scopus 로고
    • Homozygous cystathionine ß-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis
    • Kluijtmans LAJ, Boers GHJ, Verbruggen B, et al. Homozygous cystathionine ß-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis. Blood 1998; 91: 2015-8.
    • (1998) Blood , vol.91 , pp. 2015-2018
    • Kluijtmans, L.A.J.1    Boers, G.H.J.2    Verbruggen, B.3
  • 41
    • 0032929079 scopus 로고    scopus 로고
    • Factor V Leiden (Arg506Gln), a confounding genetic risk factor but not mandatory for the occurrence of venous thromboembolism in homozygotes and obligate heterozygotes for cystathionine beta-synthase deficiency
    • Yap S, O'Donnell KA, O'Neill C, et al. Factor V Leiden (Arg506Gln), a confounding genetic risk factor but not mandatory for the occurrence of venous thromboembolism in homozygotes and obligate heterozygotes for cystathionine beta-synthase deficiency. Thromb Haemost 1999; 81: 502-5.
    • (1999) Thromb Haemost , vol.81 , pp. 502-505
    • Yap, S.1    O'Donnell, K.A.2    O'Neill, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.