Covalent and noncovalent modifications induce allosteric binding behavior in a monoclonal antibody

Biochemistry

Volumn 46, Issue 6, 2007, Pages 1573-1586

  Blake II, Robert C ^a   Li, Xia ^b,c   Yu, Haini ^b   Blake, Diane A ^b  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Beijing Vegetalbe Research Center   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CURVES; INCUBATION; PROTEOLYSIS;

ANTIGENS; CHEMICAL BONDS; CONCENTRATION (PROCESS); DERIVATIVES; PROTEINS;

MONOCLONAL ANTIBODIES;

1,10 PHENANTHROLINE; 2,9 DICARBOXY 1,10 PHENANTHROLINE; CARBOCYANINE; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; INDOCYANINE GREEN; INDODICARBOCYANINE DYE; MONOCLONAL ANTIBODY; PROTEIN G; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; BINDING ASSAY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; COVALENT BOND; ENERGY TRANSFER; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION;

ALLOSTERIC REGULATION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; CHELATING AGENTS; IMMUNOASSAY; IMMUNOGLOBULIN FAB FRAGMENTS; MATHEMATICS; MICE; PHENANTHROLINES; THERMODYNAMICS; URANIUM COMPOUNDS;

ALEXA; CAPRA HIRCUS;

EID: 33846962820     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062164j     Document Type: Article

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