A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis both in vitro and in vivo

Cancer Biology and Therapy

Volumn 5, Issue 11, 2006, Pages 1474-1480

  Tang, Xuelian ^a   Li, Jing ^a   Xin, Xianliang ^a   Geng, Meiyu ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

ERK; F actin; FAK; FN; Migration; MSP; Tumor metastasis

Indexed keywords

CISPLATIN; FIBRONECTIN; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYSACCHARIDE SULFATE;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ALGA; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEWIS CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN;

EID: 33846948975     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.11.3278     Document Type: Article

References (27)

1. Sporn MB. The war on cancer. Lancet 1996; 347:1377-81.
2. Liotta LA. Cancer cell invasion and metastasis. Sci Am 1992; 266:54-9, 62-3.
3. Entschladen F, Drell IVth TL, Lang K, Joseph J, Zaenker KS. Tumor-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 2004; 5:254-8.
4. Naumov GN, MacDonald IC, Weinmeister PM, Kerkvliet N, Nadkarni KV, Wilson SM, Morris VL, Groom AC, Chambers AF. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res 2002; 62:2162-68.
5. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 2004; 430:1034-9.
6. Giese A, Bjerkvig R, Berens ME, Westphal M. Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol 2003; 21:1624-36.
7. Haga A, Funasaka T, Niinaka Y, Raz A, Nagase H. Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression. Int J Cancer 2003; 107:707-14.
8. Lefranc F, Brotchi J, Kiss R. Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J Clin Oncol 2005; 23:2411-22.
9. Liu W, Litwack ED, Stanley MJ, Langford JK, Lander AD, Sanderson RD. Heparan sulfate proteoglycans as adhesive and anti-invasive molecules. Syndecans and glypican have distinct functions. J Biol Chem 1998; 273:22825-32.
10. Moyano JV, Carnemolla B, Albar JP, Leprini A, Gaggero B, Zardi L, Garcia-Pardo A. Cooperative role for activated alpha4 beta1 integrin and chondroitin sulfate proteoglycans in cell adhesion to the heparin III domain of fibronectin. Identification of a novel heparin and cell binding sequence in repeat III5. J Biol Chem 1999; 274:135-42.
11. Woods A, Couchman JR. Syndecans: synergistic activators of cell adhesion. Trends Cell Biol 1998; 8:189-92.
12. Bereczky B, Gilly R, Raso E, Vago A, Timar J, Tovari J. Selective antimetastatic effect of heparins in preclinical human melanoma models is based on inhibition of migration and microvascular arrest. Clin Exp Metastasis 2005; 22:69-76.
13. Mishima T, Murata J, Toyoshima M, Fujii H, Nakajima M, Hayashi T, Kato T, Saiki I. Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis. Clin Exp Metastasis 1998; 16:541-50.
14. Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol 2004; 4:21.
15. Bartsch JE, Staren ED, Appert HE. Adhesion and migration of extracellular matrix-stimulated breast cancer. J Surg Res 2003; 110:287-94.
16. Belot N, Pochet R, Heizmann CW, Kiss R, Decaestecker C. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochim Biophys Acta 2002; 1600:74-83.
17. Reiske HR, Zhao J, Han DC, Cooper LA, Guan JL. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett 2000; 486:275-80.
18. Miyamoto K, Kodera N, Umekawa H, Furuichi Y, Tokita M, Komai T. Specific interactions between cryogel components: role of extradomain A containing fibronectin in cryogelation. Int J Biol Macromol 2002; 30:205-12.
19. Giganti A, Friederich E. The actin cytoskeleton as a therapeutic target: state of the art and future directions. Prog Cell Cycle Res 2003; 5:511-25.
20. Rao J, Li N. Microfilament actin remodeling as a potential target for cancer drug development. Curr Cancer Drug Targets 2004; 4:345-54.
21. Wehrle-Haller B, Imhof BA. Actin, microtubules and focal adhesion dynamics during cell migration. Int J Biochem Cell Biol 2003; 35:39-50.
22. Couchman JR, Woods A. Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci 1999; 112:3415-20.
23. Schlaepfer DD, Mitra SK. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev 2004; 14:92-101.
24. Wang Z, Newman WH. Smooth muscle cell migration stimulated by interleukin 6 is associated with cytoskeletal reorganization. J Surg Res 2003; 111:261-6.
25. Parsons JT. Focal adhesion kinase: the first ten years. J Cell Sci 2003; 116:1409-16.
26. Nakamura H, Nagaoka N, Hirata A, Inoue M, Ozawa H, Yamamoto T. Distribution of actin filaments, non-muscle myosin, M-Ras, and extracellular signal-regulated kinase (ERK) in osteoclasts after calcitonin administration. Arch Histol Cytol 2005; 68:143-50.
27. Yoshitomi Y, Nakanishi H, Kusano Y, Munesue S, Oguri K, Tatematsu M, Yamashina I, Okayama M. Inhibition of experimental lung metastases of Lewis lung carcinoma cells by chemically modified heparin with reduced anticoagulant activity. Cancer Lett 2004; 207:165-74.