Prolonged exposure of methicillin-resistant Staphylococcus aureus (MRSA) COL strain to increasing concentrations of oxacillin results in a multidrug-resistant phenotype

International Journal of Antimicrobial Agents

Volumn 29, Issue 3, 2007, Pages 302-305

  Martins, Ana ^a   Couto, Isabel ^a,b   Aagaard, Lone ^c   Martins, Marta ^a   Viveiros, Miguel ^a   Kristiansen, Jette E ^c   Amaral, Leonard ^a  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c NONE   (Denmark)

Author keywords

Adaptation; Efflux pumps; High concentration; MDR; MRSA COL; Oxacillin

Indexed keywords

AMIKACIN; CIPROFLOXACIN; ERYTHROMYCIN; ETHIDIUM BROMIDE; KANAMYCIN; METICILLIN; NORFLOXACIN; OFLOXACIN; OXACILLIN; RESERPINE; RIFAMPICIN;

ADAPTATION; ANTIBIOTIC RESISTANCE; ARTICLE; DNA FINGERPRINTING; EVALUATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ETHIDIUM; HUMANS; MEMBRANE TRANSPORT PROTEINS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; OXACILLIN; PHENOTYPE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33846939351     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2006.10.012     Document Type: Article

References (8)

1. Viveiros M., Jesus A., Brito M., et al. Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes. Antimicrob Agents Chemother 49 (2005) 3578-3582
2. Viveiros M., Portugal I., Bettencourt R., et al. Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 46 (2002) 2804-2810
3. Sobral R.G., Ludovice A.M., Gardete S., Tabei K., De Lencastre H., and Tomasz A. Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus. Microb Drug Resist 9 (2003) 231-241
4. de Lencastre H., and Tomasz A. Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 38 (1994) 2590-2598
5. Kristiansen M.M., Leandro C., Ordway D., et al. Thioridazine reduces resistance of methicillin-resistant Staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump. In vivo 20 (2006) 361-366
6. Ordway D., Viveiros M., Leandro C., Arroz M.J., and Amaral L. Intracellular activity of clinical concentrations of phenothiazines including thioridazine against phagocytosed Staphylococcus aureus. Int J Antimicrob Agents 20 (2001) 34-43
7. Martins M., Santos B., Martins A., et al. An instrument-free method for the demonstration of efflux pump activity of bacteria. In Vivo 20 (2006) 657-664
8. Chung M., de Lencastre H., Matthews P., et al. Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb Drug Resist 6 (2000) 189-198