A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized rats

Osteoporosis International

Volumn 18, Issue 3, 2007, Pages 351-362

  Iwaniec, U T ^a,b   Moore, K ^a   Rivera, M F ^a   Myers, S E ^a   Vanegas, S M ^a   Wronski, T J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Bone anabolic agents; Bone formation; Bone histomorphometry; Cancellous osteopenia; Ovariectomy; Rat

Indexed keywords

ANABOLIC AGENT; BASIC FIBROBLAST GROWTH FACTOR; CP 734432; PARATHYROID HORMONE; PROSTAGLANDIN E RECEPTOR AGONIST; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BONE MARROW; BONE MASS; CANCELLOUS BONE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; FEMALE; METAPHYSIS; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOID; OSTEOPENIA; OVARIECTOMY; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TIBIA;

ANIMALS; BODY WEIGHT; BONE DENSITY CONSERVATION AGENTS; BONE DISEASES, METABOLIC; DRUG EVALUATION, PRECLINICAL; FEMALE; FIBROBLAST GROWTH FACTOR 2; OSTEOCALCIN; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; TIBIA;

EID: 33846932327     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0240-9     Document Type: Article

References (30)

1. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R (1993) Anabolic actions of parathyroid hormone on bone. Endocr Rev 14:690-709
2. Wronski TJ, Li M (1998) PTH: skeletal effects in the ovariectomized rat model for postmenopausal bone loss. In: Whitfield JF, Morley P (eds) Anabolic Treatments for Osteoporosis. CRC Press, Boca Raton, FL, pp 59-81
3. Arlot M, Meunier PJ, Boivin G, Haddock L, Tamayo J, Correa-Rotter R, Jasqui S, Donley DW, Dalsky GP, Martin JS, Eriksen EF (2005) Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters. J Bone Miner Res 20:1244-1253
4. Qi H, Li M, Wronski TJ (1995) Comparison of the bone anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats. J Bone Miner Res 10:948-955
5. Nagai H, Tsukuda R, Mayahara H (1995) Effects of basic fibroblast growth factor (bFGF) on bone formation in growing rats. Bone 16:367-373
6. Liang H, Pun S, Wronski TJ (1999) Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats. Endocrinology 140:5780-5788
7. Iwaniec UT, Magee KA, Mitova-Caneva NG, Wronski TJ (2003) Bone anabolic effects of subcutaneous treatment with basic fibroblast growth factor alone and in combination with estrogen in osteopenic ovariectomized rats. Bone 33:380-386
8. Wronski TJ, Ratkus AM, Thomsen JS, Vulcan Q, Mosekilde Li (2001) Sequential treatment with basic fibroblast growth factor and parathyroid hormone restores lost cancellous bone mass and strength in the proximal tibia of aged ovariectomized rats. J Bone Miner Res 16:1399-1407
9. Mazue G, Bertolero F, Garofano L, Brughera M, Carminati P (1992) Experience with the preclinical assessment of basic fibroblast growth factor (bFGF). Toxicol Letters 64/65:329-338
10. Wamsley HL, Iwaniec UT, Wronski TJ (2005) Selected extra-skeletal effects of systemic treatment with basic fibroblast growth factor in ovariectomized rats. Toxicol Path 33:577-583
11. Jee WSS, Ma YF (1997) The in vivo anabolic actions of prostaglandins in bone. Bone 21:297-304
12. 2. Calcif Tissue Int 50:80-87
13. 2α on the skeleton of osteopenic ovariectomized rats. Bone 17:549-554
14. Yoshida K, Oida H, Kobayashi T, Maruyama T, Tanaka M, Katayama T, Yamaguchi K, Segi E, Tsuboyama T, Matsushita M, Ito K, Ito Y, Sugimoto Y, Ushikubi F, Ohuchida S, Kondo K, Nakamura T, Narumiya S (2002) Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc Natl Acad Sci 99:4580-4585
15. Li M, Healy DR, Li Y, Simmons HA, Crawford DT, Ke HZ, Pan LC, Brown TA, Thompson DD (2005) Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice. Bone 37:46-54
16. Hagino H, Kuraoka M, Kameyama Y, Okano T, Teshima R (2005) Effect of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the cortical bone response to mechanical loading. Bone 36:444-453
17. Ke HZ, Crawford DT, Qi H, Simmons HA, Owen TA, Paralkar VM, Li M, Lu B, Grasser WA, Cameron KO, Lefker BA, Dasilva-Jardine P, Scott DO, Zhang Q, Tian XY, Jee WSS, Brown TA, Thompson DD (2006) A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged ovariectomized rats. J Bone Miner Res 21:565-575
18. Wronski TJ, Schenck PA, Cintron M, Walsh CC (1987) Effect of body weight on osteopenia in ovariectomized rats. Calcif Tissue Int 40:155-159
19. Baron R, Vignery A, Neff L, Silvergate A, Santa Maria A (1983) Processing of undecalcified bone specimens for bone histomorphometry. In Recker RR (ed) Bone histomorphometry: techniques and interpretation. CRC Press, Boca Raton, FL, pp 13-35
20. Frost HM (1983) Processing of undecalcified bone specimens for bone histomorphometry. In Recker RR (ed) Bone Histomorphometry: techniques and interpretation. CRC Press, Boca Raton, FL, pp 109-132
21. Conover WJ (ed) (1980) Practical Nonparametric Statistics. Wiley & Sons, New York, pp 229-237
22. Andreassen TT, Melsen F, Oxlund H (1996) The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats. J Bone Miner Res 11:1094-1102
23. Mosekilde Li, Tornvig L, Thomsen JS, Orhii PB, Banu MJ, Kalu DN (2000) Parathyroid hormone and growth hormone have additive and synergetic effect when used as intervention treatment in ovariectomized rats with established osteopenia. Bone 26:643-651
24. Bravenboer N, Holzmann PJ, ter Maaten JC, Stuurman LM, Roos JC, Lips P (2005) Effect of long-term growth hormone treatment on bone mass and bone metabolism in growth hormone-deficient men. J Bone Miner Res 20:1778-1784
25. Sibonga JD, Zhang M, Ritman EL, Turner RT (2000) Restoration of bone mass in the severely osteopenic senescent rat. J Gerontol A Biol Sci Med Sci 55:B71-B78
26. Suzawa T, Miyaura C, Inada M, Maruyama T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T (2000) The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141:1554-1559
27. Tomita M, Li X, Okada Y, Woodiel FN, Young RN, Pilbeam CC, Raisz LG (2002) Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro. Bone 30:159-163
28. Akhter MP, Cullen DM, Gong G, Recker RR (2001) Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice. Bone 29:121-125
29. 2 agonist stimulates local bone formation and enhances fracture healing. Bone 18:2033-2042
30. Wronski TJ, Yen C-F, Qi H, Dann LM (1993) Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831