Chronic high-inspired CO2 decreases excitability of mouse hippocampal neurons

Journal of Neurophysiology

Volumn 97, Issue 2, 2007, Pages 1833-1838

  Gu, Xiang Q ^a   Kanaan, Amjad ^a   Yao, Hang ^a   Haddad, Gabriel G ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; CARBON DIOXIDE BREATHING; CELL FUNCTION; CHANNEL GATING; CONTROLLED STUDY; HIPPOCAMPUS; MEMBRANE STEADY POTENTIAL; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM CURRENT; STEADY STATE; WESTERN BLOTTING;

ACTION POTENTIALS; ADMINISTRATION, INHALATION; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BLOTTING, WESTERN; CARBON DIOXIDE; CELLS, CULTURED; CHRONIC DISEASE; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPERCAPNIA; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS;

EID: 33846924991     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01174.2006     Document Type: Article

References (18)

1. Balestrino M, Somjen GG. Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. J Physiol 396: 247-266, 1988.
2. Brackett NC Jr, Cohen JJ, Schwartz WB. Carbon dioxide titration curve of normal man. effect of increasing degrees of acute hypercapnia on acid-base equilibrium. N Engl J Med 272: 6-12, 1965.
3. Brown EW. The physiological effects of high concentrations of carbon dioxide. US Nav Med Bull 28: 721-734, 1930.
4. Bruehl C, Witte OW. Relation between bicarbonate concentration and voltage dependence of sodium currents in freshly isolated CA1 neurons of the rat. J Neurophysiol 89: 2489-2498, 2003.
5. CO2 at physiological levels. J Cell Physiol 189: 229-236, 2001.
6. 2 to cortical excitability via pH. Neuron 48: 1011-23, 2005.
7. Gu XQ, Haddad GG. Maturation of neuronal excitability in hippocampal neurons of mice chronically exposed to cyclic hypoxia. Am J Physiol Cell Physiol 284: C1156-C1163, 2003.
8. 2 on CA1 neuronal excitability. Am J Physiol Cell Physiol 287: C691-C697, 2004.
9. Gu XQ, Yao H, Haddad GG. Effect of extracellular HCO(3)(-) on Na(+) channel characteristics in hippocampal CA1 neurons. J Neurophysiol 84: 2477-2483, 2000.
10. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch 391: 85-100, 1981.
11. Li G, Zhou D, Vincencio AG, Ryu J, Xue J, Haddad GG. Effect of carbon dioxide on neonatal mouse lung: a genomic approach. J Appl Physiol 101: 1556-64, 2006.
12. + current in rat hippocampal neurones via protein kinase C. J Physiol 503: 479-488, 1997.
13. Otsuka K. Hypertension and altered cardiovascular variability associated with obstructive sleep apnea. Nippon Rinsho 58: 1711-1716, 2000.
14. Schaller KL, Krzemien DM, Yarowsky PJ, Krueger BK, Caldwell JH. A novel, abundant sodium channel expressed in neurons and glia. J Neurosci 15: 3231-42, 1995.
15. Sieker HO, Hickam JB. Carbon dioxide intoxication: the clinical syndrome, its etiology and management with particular reference to the use of mechanical respirators. Medicine 35: 389-423, 1956.
16. Simakajornboon N, Graff GR, Torres JE, Gozal D. Modulation of hypoxic ventilatory response by systemic platelet-activating factor receptor antagonist in the rat. Respir Physiol 114: 213-225, 1998.
17. + channels in rat brain. J Comp Neurol 345: 279-87, 1994.
18. + channels by decreases in intra- and extracellular pH. J Cell Physiol 183: 53-64, 2000.