Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast

Pathology International

Volumn 57, Issue 3, 2007, Pages 126-132

  Ichihara, Shu ^a,d   Fujimoto, Takuya ^b   Hashimoto, Katsunori ^b   Moritani, Suzuko ^a   Hasegawa, Masaki ^c   Yokoi, Toyoharu ^b  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

Author keywords

Atypical ductal hyperplasia; Atypical papilloma; Breast cancer; Double immunostain; Ductal carcinoma in situ; Intraductal papillary carcinoma; Intraductal papilloma; Keratins; p63; WHO classification

Indexed keywords

ANTIBODY; CHROMOGENIC SUBSTRATE; CYTOKERATIN; HIGH MOLECULAR WEIGHT CYTOKERATIN; PROTEIN P63; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BENIGN TUMOR; BREAST PAPILLOMA; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; MYOEPITHELIUM CELL; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, PAPILLARY; DNA-BINDING PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; KERATINS; MAMMARY GLANDS, HUMAN; MIDDLE AGED; MOLECULAR WEIGHT; PAPILLOMA, INTRADUCTAL; RETROSPECTIVE STUDIES; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 33846923077     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2006.02069.x     Document Type: Article

References (25)

1. Kraus FT, Neubecker RD. The differential diagnosis of papillary tumors of the breast. Cancer 1962; 15: 444-55.
2. Azzopardi JG, Ahmed A, Millis RR. Problems in breast pathology. Major Probl Pathol 1979; 11: i-xvi, 1-466.
3. Page DL, Salhany KE, Jensen RA, Dupont WD. Subsequent breast carcinoma risk after biopsy with atypia in a breast papilloma. Cancer 1996; 78: 258-66.
4. Raju U, Vertes D. Breast papillomas with atypical ductal hyperplasia: A clinicopathologic study. Hum Pathol 1996; 27: 1231-8.
5. MacGrogan G, Tavassoli FA. Central atypical papillomas of the breast: A clinicopathological study of 119 cases. Virchows Arch 2003; 443: 609-17.
6. Ali-Fehmi R, Carolin K, Wallis T, Visscher DW. Clinicopathologic analysis of breast lesions associated with multiple papillomas. Hum Pathol 2003; 34: 234-9.
7. Ichihara S, Koshikawa T, Nakamura S, Yatabe Y, Kato K. Epithelial hyperplasia of usual type expresses both S100-alpha and S100-beta in a heterogeneous pattern but ductal carcinoma in situ can express only S100-alpha in a monotonous pattern. Histopathology 1997; 30: 533-41.
8. Boecker W, Buerger H, Schmitz K et al. Ductal epithelial proliferations of the breast: A biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. J Pathol 2001; 195: 415-21.
9. Raju U, Crissman JD, Zarbo RJ, Gottlieb C. Epitheliosis of the breast. An immunohistochemical characterization and comparison to malignant intraductal proliferations of the breast. Am J Surg Pathol 1990; 14: 939-47.
10. Moinfar F, Man YG, Lininger RA, Bodian C, Tavassoli FA. Use of keratin 35betaE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type: benign and malignant intraductal proliferations. Am J Surg Pathol 1999; 23: 1048-58.
11. Tan PH, Aw MY, Yip G et al. Cytokeratins in papillary lesions of the breast: Is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? Am J Surg Pathol 2005; 29: 625-32.
12. Tse GM, Tan PH, Lui PC et al. The role of immunohistochemistry for smooth muscle actin, p63, CD10 and CK 14 in the differential diagnosis of papillary lesions of the breast. J Clin Pathol 2006; (Epub ahead of print) 10.1136/jcp.2006.036830.
13. Raju UB, Lee MW, Zarbo RJ, Crissman JD. Papillary neoplasia of the breast: Immunohistochemically defined myoepithelial cells in the diagnosis of benign and malignant papillary breast neoplasms. Mod Pathol 1989; 2: 569-76.
14. Soini Y, Miettinen M. Immunohistochemical evaluation of the cytoarchitecture of benign and malignant breast lesions. APMIS 1992; 100: 901-7.
15. Putti TC, Pinder SE, Elston CW, Lee AH, Ellis IO. Breast pathology practice: Most common problems in a consultation service. Histopathology 2005; 47: 445-57.
16. Barbareschi M, Pecciarini L, Cangi MG et al. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol 2001; 25: 1054-60.
17. Tavassoli FA, ed. Intraductal Papillary Neoplasms in Tumors of the Breast. Lyon: IARC Press, 2003.
18. Nagle RB, Bocker W, Davis JR et al. Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J Histochem Cytochem 1986; 34: 869-81.
19. Bocker W, Bier B, Freytag G et al. An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ. Virchows Arch A Pathol Anat Histopathol 1992; 421: 323-30.
20. Gown AM, Vogel AM. Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am J Pathol 1984; 114: 309-21.
21. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC. A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 1995; 43: 97-102.
22. Sternberger LA, Joseph SA. The unlabeled antibody method. Contrasting color staining of paired pituitary hormones without antibody removal. J Histochem Cytochem 1979; 27: 1424-9.
23. Krenacs T, Krenacs L, Bozoky B, Ivanyi B. Double and triple immunocytochemical labelling at the light microscope level in histopathology. Histochem J 1990; 22: 530-36.
24. Bryan BB, Schnitt SJ, Collins LC. Ductal carcinoma in situ with basal-like phenotype: A possible precursor to invasive basal-like breast cancer. Mod Pathol 2006; 19: 617-21.
25. Lerwill MF. Current practical applications of diagnostic immunohistochemistry in breast pathology. Am J Surg Pathol 2004; 28: 1076-91.