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Volumn 5, Issue 4, 2006, Pages 259-272

Exemestane: A review of its use as adjuvant treatment for early breast cancer in postmenopausal women

Author keywords

Early breast cancer; Exemestane; Pharmacodynamics; Pharmacokinetics; Postmenopausal; Therapeutic use; Tolerability

Indexed keywords

ALDOSTERONE; ANASTROZOLE; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITOR; CYTOCHROME P450 3A4; ESTROGEN; ESTROGEN RECEPTOR; EXEMESTANE; FOLLITROPIN; HYDROCORTISONE; HYDROXYPROGESTERONE; KETOCONAZOLE; LETROZOLE; LUTEINIZING HORMONE; PHENYTOIN; PLACEBO; PRASTERONE SULFATE; RIFAMPICIN; SEX HORMONE BINDING GLOBULIN; TAMOXIFEN; TESTOSTERONE;

EID: 33846922067     PISSN: 11756357     EISSN: None     Source Type: Journal    
DOI: 10.2165/00024669-200605040-00005     Document Type: Review
Times cited : (4)

References (56)
  • 1
    • 0036615820 scopus 로고    scopus 로고
    • Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (review)
    • Jun;
    • Crucitta E, Fornier MN, Locopo N, et al. Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (review). Int J Oncol 2002 Jun; 20 (6): 1283-8
    • (2002) Int J Oncol , vol.20 , Issue.6 , pp. 1283-1288
    • Crucitta, E.1    Fornier, M.N.2    Locopo, N.3
  • 2
    • 0034049569 scopus 로고    scopus 로고
    • Exemestane: A review of its use in postmenopausal women with advanced breast cancer
    • Jun;
    • Clemett D, Lamb HM. Exemestane: a review of its use in postmenopausal women with advanced breast cancer. Drugs 2000 Jun; 59 (6): 1279-96
    • (2000) Drugs , vol.59 , Issue.6 , pp. 1279-1296
    • Clemett, D.1    Lamb, H.M.2
  • 3
    • 20044382779 scopus 로고    scopus 로고
    • American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: Status
    • Jan 20;
    • Winer EP, Hudis C, Burstein HJ, et al. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004. J Clin Oncol 2005 Jan 20; 23 (3): 619-29
    • (2005) J Clin Oncol , vol.23 , Issue.3 , pp. 619-629
    • Winer, E.P.1    Hudis, C.2    Burstein, H.J.3
  • 4
    • 29144506097 scopus 로고    scopus 로고
    • Are all aromatase inhibitors the same? A review of controlled clinical trials in breast cancer
    • Nov;
    • Berry J. Are all aromatase inhibitors the same? A review of controlled clinical trials in breast cancer. Clin Ther 2005 Nov; 27 (11): 1671-84
    • (2005) Clin Ther , vol.27 , Issue.11 , pp. 1671-1684
    • Berry, J.1
  • 5
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group, May 16;
    • Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 1998 May 16; 351 (9114): 1451-67
    • (1998) Lancet , vol.351 , Issue.9114 , pp. 1451-1467
  • 6
    • 27944460410 scopus 로고    scopus 로고
    • Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: Results from a randomized trial
    • Nov 2;
    • Nordenskjöld B, Rosell J, Rutqvist L-E, et al. Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: results from a randomized trial. J Natl Cancer Inst 2005 Nov 2; 97 (21): 1609-10
    • (2005) J Natl Cancer Inst , vol.97 , Issue.21 , pp. 1609-1610
    • Nordenskjöld, B.1    Rosell, J.2    Rutqvist, L.-E.3
  • 7
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group EBCTCG, May 14;
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005 May 14; 365 (9472): 1687-717
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 8
    • 4644247253 scopus 로고    scopus 로고
    • Switching trial of adjuvant tamoxifen with an aromatase inhibitor in postmenopausal patients with breast cancer
    • Sep;
    • Boccardo F. Switching trial of adjuvant tamoxifen with an aromatase inhibitor in postmenopausal patients with breast cancer. Clin Breast Cancer 2004 Sep; 5 Suppl. 1: S13-7
    • (2004) Clin Breast Cancer , vol.5 , Issue.SUPPL. 1
    • Boccardo, F.1
  • 9
    • 0036839717 scopus 로고    scopus 로고
    • Buzdar AU, Robertson JFR, Eiermann W, et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Cancer 2002 Nov 1; 95 (9): 2006-16
    • Buzdar AU, Robertson JFR, Eiermann W, et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Cancer 2002 Nov 1; 95 (9): 2006-16
  • 11
    • 33846905223 scopus 로고    scopus 로고
    • AstraZeneca Pharmaceuticals. Arimidex (anastrozole tablets): prescribing information (US) [online]. Available from URL: http://www.accessdata.fda.gov/ scripts/cder/drugsatfda/ [Accessed 2006 Mar 3]
    • AstraZeneca Pharmaceuticals. Arimidex (anastrozole tablets): prescribing information (US) [online]. Available from URL: http://www.accessdata.fda.gov/ scripts/cder/drugsatfda/ [Accessed 2006 Mar 3]
  • 12
    • 33846923784 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation, US, online, Available from URL:, Accessed Mar 3
    • Novartis Pharmaceuticals Corporation. Femara (letrozole tablets): prescribing information (US) [online]. Available from URL: http://www. accessdata.fda.gov/scripts/cder/drugsatfda/ [Accessed 2006 Mar 3]
    • (2006) Femara (letrozole tablets): Prescribing information
  • 13
    • 10744223655 scopus 로고    scopus 로고
    • A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. Intergroup Exemestane Study
    • Mar 11;
    • Coombes RC, Hall E, Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. Intergroup Exemestane Study. N Engl J Med 2004 Mar 11; 350 (11): 1081-92
    • (2004) N Engl J Med , vol.350 , Issue.11 , pp. 1081-1092
    • Coombes, R.C.1    Hall, E.2    Gibson, L.J.3
  • 14
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Jan;
    • Howell A, Cuzick J, Baum M, et al. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 2005 Jan; 365 (9453): 60-2
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3
  • 15
    • 29544433211 scopus 로고    scopus 로고
    • A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. The Breast International Group (BIG) 1-98 Collaborative Group
    • Dec 29;
    • Thürlimann B, Keshaviah A, Coates AS, et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. The Breast International Group (BIG) 1-98 Collaborative Group. N Engl J Med 2005 Dec 29; 353 (26): 2747-57
    • (2005) N Engl J Med , vol.353 , Issue.26 , pp. 2747-2757
    • Thürlimann, B.1    Keshaviah, A.2    Coates, A.S.3
  • 16
    • 7444259675 scopus 로고    scopus 로고
    • A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    • Nov 6;
    • Goss PE, Ingle JN, Martino S, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 2003 Nov 6; 349 (19): 1793-802
    • (2003) N Engl J Med , vol.349 , Issue.19 , pp. 1793-1802
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 17
    • 24744450378 scopus 로고    scopus 로고
    • Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: Updated findings from NCIC CTG MA.17
    • Sep 7;
    • Goss PE, Ingle JN, Martino S, et al. Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst 2005 Sep 7; 97 (17): 1262-71
    • (2005) J Natl Cancer Inst , vol.97 , Issue.17 , pp. 1262-1271
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 18
    • 23444446523 scopus 로고    scopus 로고
    • Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: Combined results of ABCSG trial 8 and ARNO 95 trial. The Austrian Breast and Colorectal Cancer Study Group and the German Adjuvant Breast Cancer Group
    • Aug 6;
    • Jakesz R, Jonat W, Gnant M, et al. Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. The Austrian Breast and Colorectal Cancer Study Group and the German Adjuvant Breast Cancer Group. Lancet 2005 Aug 6; 366 (9484): 455-62
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 455-462
    • Jakesz, R.1    Jonat, W.2    Gnant, M.3
  • 19
    • 24644434439 scopus 로고    scopus 로고
    • Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer
    • Aug 1;
    • Lønning PE, Geisler J, Krag LE, et al. Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer. J Clin Oncol 2005 Aug 1; 23 (22): 5126-37
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 5126-5137
    • Lønning, P.E.1    Geisler, J.2    Krag, L.E.3
  • 20
    • 14644406843 scopus 로고    scopus 로고
    • Endocrine effects of tamoxifen plus exemestane in postmenopausal women with breast cancer
    • Feb 15;
    • Love RR, Hutson PR, Havighurst TC, et al. Endocrine effects of tamoxifen plus exemestane in postmenopausal women with breast cancer. Clin Cancer Res 2005 Feb 15; 11 (4): 1500-3
    • (2005) Clin Cancer Res , vol.11 , Issue.4 , pp. 1500-1503
    • Love, R.R.1    Hutson, P.R.2    Havighurst, T.C.3
  • 21
    • 24044489574 scopus 로고    scopus 로고
    • Effect of exemestane on the lipidemic profile of post-menopausal operable breast cancer patients following 5-7 years of adjuvant tamoxifen: Preliminary results of the ATENA substudy
    • Sep;
    • Markopoulos C, Chrissochou M, Michailidou A, et al. Effect of exemestane on the lipidemic profile of post-menopausal operable breast cancer patients following 5-7 years of adjuvant tamoxifen: preliminary results of the ATENA substudy. Anticancer Drugs 2005 Sep; 16 (8): 879-83
    • (2005) Anticancer Drugs , vol.16 , Issue.8 , pp. 879-883
    • Markopoulos, C.1    Chrissochou, M.2    Michailidou, A.3
  • 22
    • 24044527243 scopus 로고    scopus 로고
    • The effect of exemestane on the lipidemic profile of postmenopausal early breast cancer patients: Preliminary results of the TEAM Greek sub-study
    • Sep;
    • Markopoulos C, Polychronis A, Zobolas V, et al. The effect of exemestane on the lipidemic profile of postmenopausal early breast cancer patients: preliminary results of the TEAM Greek sub-study. Breast Cancer Res Treat 2005 Sep; 93(1): 61-6
    • (2005) Breast Cancer Res Treat , vol.93 , Issue.1 , pp. 61-66
    • Markopoulos, C.1    Polychronis, A.2    Zobolas, V.3
  • 23
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Sep;
    • Geisler J, King N, Anker G, et al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res 1998 Sep; 4 (9): 2089-93
    • (1998) Clin Cancer Res , vol.4 , Issue.9 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3
  • 24
    • 0030748661 scopus 로고    scopus 로고
    • Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: A phase I study
    • Jul;
    • Johannessen DC, Engan T, Di Salle E, et al. Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: a phase I study. Clin Cancer Res 1997 Jul; 3 (7): 1101-8
    • (1997) Clin Cancer Res , vol.3 , Issue.7 , pp. 1101-1108
    • Johannessen, D.C.1    Engan, T.2    Di Salle, E.3
  • 25
    • 0033035448 scopus 로고    scopus 로고
    • Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients
    • Feb;
    • Anker GB, Refsum H, Ueland PM, et al. Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients. Clin Chem 1999 Feb; 45 (2): 252-6
    • (1999) Clin Chem , vol.45 , Issue.2 , pp. 252-256
    • Anker, G.B.1    Refsum, H.2    Ueland, P.M.3
  • 26
    • 0026446844 scopus 로고
    • Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women
    • Nov 1;
    • Evans TR, Di Salle E, Ornati G, et al. Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women. Cancer Res 1992 Nov 1; 52 (21): 5933-9
    • (1992) Cancer Res , vol.52 , Issue.21 , pp. 5933-5939
    • Evans, T.R.1    Di Salle, E.2    Ornati, G.3
  • 27
    • 33846921039 scopus 로고    scopus 로고
    • Lipid profile and homocysteine levels in postmenopausal women with early breast cancer at low risk treated for two years with exemestane: Follow-up results of a randomized, placebo-controlled study
    • abstract no. 4108 plus poster, Dec 8-11; San Antonio TX
    • Lønning PE, Geisler J, Krag L, et al. Lipid profile and homocysteine levels in postmenopausal women with early breast cancer at low risk treated for two years with exemestane: follow-up results of a randomized, placebo-controlled study [abstract no. 4108 plus poster]. 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Lønning, P.E.1    Geisler, J.2    Krag, L.3
  • 28
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke
    • Homocysteine Studies Collaboration, Oct;
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke. JAMA 2002 Oct; 288 (16): 2015-22
    • (2002) JAMA , vol.288 , Issue.16 , pp. 2015-2022
  • 29
    • 2542446523 scopus 로고    scopus 로고
    • The effects of degree of hepatic or renal impairment on the pharmacokinetics of exemestane in postmenopausal women
    • Jun;
    • Jannuzzo MG, Poggesi I, Spinelli R, et al. The effects of degree of hepatic or renal impairment on the pharmacokinetics of exemestane in postmenopausal women. Cancer Chemother Pharmacol 2004 Jun; 53 (6): 475-81
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.6 , pp. 475-481
    • Jannuzzo, M.G.1    Poggesi, I.2    Spinelli, R.3
  • 30
    • 0001238487 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of Aromasin® (exemestane, EXE) after single and repeated doses in healthy postmenopausal volunteers (HPV) [abstract no. 1185]
    • Sep;
    • Spinelli R, Jannuzzo MG, Poggesi I, et al. Pharmacokinetics (PK) of Aromasin® (exemestane, EXE) after single and repeated doses in healthy postmenopausal volunteers (HPV) [abstract no. 1185]. Eur J Cancer 1999 Sep; 35 Suppl. 4: 295
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4 , pp. 295
    • Spinelli, R.1    Jannuzzo, M.G.2    Poggesi, I.3
  • 31
    • 0011308655 scopus 로고    scopus 로고
    • Inhibition of CYP3A4 does not influence Aromasin® (exemestane, EXE) pharmacokinetics (PK) in healthy postmenopausal volunteers (HPV) [abstract no. 1184]
    • Sep;
    • Jannuzzo MG, Spinelli R, Poggesi I, et al. Inhibition of CYP3A4 does not influence Aromasin® (exemestane, EXE) pharmacokinetics (PK) in healthy postmenopausal volunteers (HPV) [abstract no. 1184]. Eur J Cancer 1999 Sep; 35 Suppl. 4: 294
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4 , pp. 294
    • Jannuzzo, M.G.1    Spinelli, R.2    Poggesi, I.3
  • 32
    • 0003213592 scopus 로고    scopus 로고
    • Effect of food and formulation on the pharmacokinetics (PK) and pharmacodynamics (PD) or a single oral dose of exemestane (Aromasin®, EXE) [abstract no. 741]
    • Poggesi I, Jannuzzo MG, Di Salle E, et al. Effect of food and formulation on the pharmacokinetics (PK) and pharmacodynamics (PD) or a single oral dose of exemestane (Aromasin®, EXE) [abstract no. 741]. Proc Am Soc Clin Oncol 1999; 18: 193a
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Poggesi, I.1    Jannuzzo, M.G.2    Di Salle, E.3
  • 33
    • 33846937019 scopus 로고    scopus 로고
    • Persiani S, Poggesi I, Cicioni P, et al. Pharmacokinetics of repeated low-doses of exemestane (1, 2.5, 5, and 10mg) in postmenopausal healthy volunteers [abstract no. 952]. Eur J Cancer 1995 Nov; 31 Suppl. 5: S198
    • Persiani S, Poggesi I, Cicioni P, et al. Pharmacokinetics of repeated low-doses of exemestane (1, 2.5, 5, and 10mg) in postmenopausal healthy volunteers [abstract no. 952]. Eur J Cancer 1995 Nov; 31 Suppl. 5: S198
  • 34
    • 33644896808 scopus 로고    scopus 로고
    • Quality of life in the Intergroup Exemestane Study: A randomized trial of exemestane versus continued tamoxifen after 2 to 3 years of tamoxifen in postmenopausal women with primary breast cancer
    • Feb 20;
    • Fallowfield LJ, Bliss JM, Porter LS, et al. Quality of life in the Intergroup Exemestane Study: a randomized trial of exemestane versus continued tamoxifen after 2 to 3 years of tamoxifen in postmenopausal women with primary breast cancer. J Clin Oncol 2006 Feb 20; 24 (6): 910-7
    • (2006) J Clin Oncol , vol.24 , Issue.6 , pp. 910-917
    • Fallowfield, L.J.1    Bliss, J.M.2    Porter, L.S.3
  • 35
    • 33646792349 scopus 로고    scopus 로고
    • Skeletal effect of exemestane in the Intergroup Exemestane Study (IES) - 2 year bone mineral density (BMD) and bone biomarker data
    • abstract no. 5076 plus poster, Dec 8-11; San Antonio TX
    • Coleman RE, Banks LM, Girgis SI, et al. Skeletal effect of exemestane in the Intergroup Exemestane Study (IES) - 2 year bone mineral density (BMD) and bone biomarker data [abstract no. 5076 plus poster]. 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Coleman, R.E.1    Banks, L.M.2    Girgis, S.I.3
  • 36
    • 33846939744 scopus 로고    scopus 로고
    • Intergroup Exemestane Study: Results of the endometrial sub-protocol [abstract no. 402]. Breast Cancer Res Treat 2004; 88 Suppl. 1: 35. Plus poster
    • presented at the, Dec 8-11; San Antonio TX
    • Bertelli G, Hall E, Bliss JM, et al. Intergroup Exemestane Study: results of the endometrial sub-protocol [abstract no. 402]. Breast Cancer Res Treat 2004; 88 Suppl. 1: 35. Plus poster presented at the 27th Annual San Antonio Breast Cancer Symposium; 2004 Dec 8-11; San Antonio (TX)
    • (2004) 27th Annual San Antonio Breast Cancer Symposium
    • Bertelli, G.1    Hall, E.2    Bliss, J.M.3
  • 37
    • 21044435630 scopus 로고    scopus 로고
    • The Intergroup Exemestane Study: A randomized trial in postmenopausal patients with early breast cancer who remain disease-free after two to three years of tamoxifen - updated survival analysis [abstract no. 3]. Breast Cancer Res Treat 2004; 88 Suppl. 1: 7
    • Dec 8-11; San Antonio TX
    • Coombes RC, Hall E, Snowdon CF, et al. The Intergroup Exemestane Study: a randomized trial in postmenopausal patients with early breast cancer who remain disease-free after two to three years of tamoxifen - updated survival analysis [abstract no. 3]. Breast Cancer Res Treat 2004; 88 Suppl. 1: 7. Plus oral presentation at the 27th Annual San Antonio Breast Cancer Symposium; 2004 Dec 8-11; San Antonio (TX)
    • (2004) Plus oral presentation at the 27th Annual San Antonio Breast Cancer Symposium
    • Coombes, R.C.1    Hall, E.2    Snowdon, C.F.3
  • 38
    • 33846914631 scopus 로고    scopus 로고
    • Coombes RC, Paridaens R, Jassem J, et al. First mature analysis of the Intergroup Exemestane Study [abstract no. LBA527]. J Clin Oncol 2006 Jun 20; 24 (18): 933s. Plus oral presentation at the 42nd Annual Meeting of the American Society of Clinical Oncology; 2006 Jun 2-6; Atlanta (GA)
    • Coombes RC, Paridaens R, Jassem J, et al. First mature analysis of the Intergroup Exemestane Study [abstract no. LBA527]. J Clin Oncol 2006 Jun 20; 24 (18): 933s. Plus oral presentation at the 42nd Annual Meeting of the American Society of Clinical Oncology; 2006 Jun 2-6; Atlanta (GA)
  • 39
    • 33846907139 scopus 로고    scopus 로고
    • Lønning PE, Geisler J, Krag LE, et al. Changes in bone metabolism after 2 years' treatment with exemestane (E) in postmenopausal women with early breast cancer (EBC) at low risk: follow-up (FU) results of a randomized placebo-controlled study [abstract no. 531]. J Clin Oncol 2005 Jun 1; 23 (16 Suppl.): 11. Plus poster presented at the 41st Annual Meeting of the American Society of Clinical Oncology; 2005 May 13-17; Orlando (FL)
    • Lønning PE, Geisler J, Krag LE, et al. Changes in bone metabolism after 2 years' treatment with exemestane (E) in postmenopausal women with early breast cancer (EBC) at low risk: follow-up (FU) results of a randomized placebo-controlled study [abstract no. 531]. J Clin Oncol 2005 Jun 1; 23 (16 Suppl.): 11. Plus poster presented at the 41st Annual Meeting of the American Society of Clinical Oncology; 2005 May 13-17; Orlando (FL)
  • 40
    • 0141650790 scopus 로고    scopus 로고
    • Origin and characteristics of adverse events in aromatase inhibition therapy for breast cancer
    • Aug;
    • Dowsett M. Origin and characteristics of adverse events in aromatase inhibition therapy for breast cancer. Semin Oncol 2003 Aug; 30 (4 Suppl. 14): 58-69
    • (2003) Semin Oncol , vol.30 , Issue.4 SUPPL. 14 , pp. 58-69
    • Dowsett, M.1
  • 41
    • 27144448752 scopus 로고    scopus 로고
    • New developments in the treatment of postmenopausal breast cancer
    • Nov;
    • Howell A. New developments in the treatment of postmenopausal breast cancer. Trends Endocrinol Metab 2005 Nov; 16 (9): 420-8
    • (2005) Trends Endocrinol Metab , vol.16 , Issue.9 , pp. 420-428
    • Howell, A.1
  • 42
    • 12144261111 scopus 로고    scopus 로고
    • Endocrine therapy trials of aromatase inhibitors for breast cancer in the adjuvant and prevention settings
    • Jan 15;, s
    • Ingle JN. Endocrine therapy trials of aromatase inhibitors for breast cancer in the adjuvant and prevention settings. Clin Cancer Res 2005 Jan 15; 11 (2 Pt 2): 900-5s
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 2 , pp. 900-905
    • Ingle, J.N.1
  • 43
    • 3242796665 scopus 로고    scopus 로고
    • Current status of aromatase inhibitors in the management of breast cancer and critique of the NCIC MA-17 trial
    • Jul-Aug;
    • Baum M. Current status of aromatase inhibitors in the management of breast cancer and critique of the NCIC MA-17 trial. Cancer Control 2004 Jul-Aug; 11 (4): 217-21
    • (2004) Cancer Control , vol.11 , Issue.4 , pp. 217-221
    • Baum, M.1
  • 44
    • 33745886262 scopus 로고    scopus 로고
    • Benefit with aromatase inhibitors in the adjuvant setting for postmenopausal women with breast cancer
    • Mouridsen HT, Robert NJ. Benefit with aromatase inhibitors in the adjuvant setting for postmenopausal women with breast cancer. MedGenMed 2005; 7 (3): 20
    • (2005) MedGenMed , vol.7 , Issue.3 , pp. 20
    • Mouridsen, H.T.1    Robert, N.J.2
  • 45
    • 23744438771 scopus 로고    scopus 로고
    • The role of aromatase inhibitors as adjuvant therapy for early breast cancer in postmenopausal women
    • Aug;
    • Mouridsen HT, Robert NJ. The role of aromatase inhibitors as adjuvant therapy for early breast cancer in postmenopausal women. Eur J Cancer 2005 Aug; 41 (12): 1678-89
    • (2005) Eur J Cancer , vol.41 , Issue.12 , pp. 1678-1689
    • Mouridsen, H.T.1    Robert, N.J.2
  • 46
    • 20344375206 scopus 로고    scopus 로고
    • Aromatase inhibitors as adjuvant therapy for postmenopausal patients with early stage breast cancer
    • Kudchadkar R, O'Regan RM. Aromatase inhibitors as adjuvant therapy for postmenopausal patients with early stage breast cancer. CA Cancer J Clin 2005; 55 (3): 145-63
    • (2005) CA Cancer J Clin , vol.55 , Issue.3 , pp. 145-163
    • Kudchadkar, R.1    O'Regan, R.M.2
  • 47
    • 24944494988 scopus 로고    scopus 로고
    • The effects of aromatase inhibitors on lipids and thrombosis
    • Aug;
    • Bundred NJ. The effects of aromatase inhibitors on lipids and thrombosis. Br J Cancer 2005 Aug; 93 Suppl. 1: S23-7
    • (2005) Br J Cancer , vol.93 , Issue.SUPPL. 1
    • Bundred, N.J.1
  • 48
    • 23944482923 scopus 로고    scopus 로고
    • Safety considerations of adjuvant therapy in early breast cancer in postmenopausal women
    • Gradishar WJ. Safety considerations of adjuvant therapy in early breast cancer in postmenopausal women. Oncology 2005; 69 (1): 1-9
    • (2005) Oncology , vol.69 , Issue.1 , pp. 1-9
    • Gradishar, W.J.1
  • 49
    • 12144274735 scopus 로고    scopus 로고
    • Exemestane for breast cancer prevention: A feasible strategy?
    • Jan 15;, s
    • Lønning PE. Exemestane for breast cancer prevention: a feasible strategy? Clin Cancer Res 2005 Jan 15; 11 (2 Pt 2): 918-24s
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 2 , pp. 918-924
    • Lønning, P.E.1
  • 50
    • 33646404613 scopus 로고    scopus 로고
    • Effects of third-generation aromatase inhibitors on bone
    • Mar;
    • McCloskey E. Effects of third-generation aromatase inhibitors on bone. Eur J Cancer 2006 Mar; 42 (8): 1044-51
    • (2006) Eur J Cancer , vol.42 , Issue.8 , pp. 1044-1051
    • McCloskey, E.1
  • 51
    • 33846940222 scopus 로고    scopus 로고
    • Cost-effectiveness of switching to exemestane following two-to-three years of therapy with tamoxifen in postmenopausal women with primary breast cancer [abstract no. 5037]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 218. Plus poster
    • presented at the, Dec 8-11; San Antonio TX
    • Thompson D, Taylor DCA, Montoya EL, et al. Cost-effectiveness of switching to exemestane following two-to-three years of therapy with tamoxifen in postmenopausal women with primary breast cancer [abstract no. 5037]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 218. Plus poster presented at the 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Thompson, D.1    Taylor, D.C.A.2    Montoya, E.L.3
  • 52
    • 33846935938 scopus 로고    scopus 로고
    • Modeling for cost-effective strategies in adjuvant hormonal therapy for postmenopausal women with breast cancer: Upfront aromatase inhibitors vs sequential tamoxifen-aromatase inhibitors [abstract no. 5089]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 237-8. Plus poster
    • presented at the, Dec 8-11; San Antonio TX
    • Younis T, Rayson D, Dewar R, et al. Modeling for cost-effective strategies in adjuvant hormonal therapy for postmenopausal women with breast cancer: upfront aromatase inhibitors vs sequential tamoxifen-aromatase inhibitors [abstract no. 5089]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 237-8. Plus poster presented at the 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Younis, T.1    Rayson, D.2    Dewar, R.3
  • 53
    • 33846909224 scopus 로고    scopus 로고
    • Economic evaluation of switching to exemestane at 2.5 years versus continuing tamoxifen as adjuvant therapy in early breast cancer: A Canadian perspective [abstract no. 2050]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 101. Plus poster
    • presented at the, Dec 8-11; San Antonio TX
    • Risebrough NA, Verma S, Trudeau M, et al. Economic evaluation of switching to exemestane at 2.5 years versus continuing tamoxifen as adjuvant therapy in early breast cancer: a Canadian perspective [abstract no. 2050]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 101. Plus poster presented at the 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Risebrough, N.A.1    Verma, S.2    Trudeau, M.3
  • 54
    • 33846900649 scopus 로고    scopus 로고
    • Cost-utility evaluation of adjuvant hormonal options in postmenopausal women with breast cancer: Tamoxifen vs. anastrazole vs. tamoxifen then exemestane [abstract no. 5036]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 217-8. Plus poster
    • presented at the, Dec 8-11; San Antonio TX
    • Skedgel C, Rayson D, Dewar R, et al. Cost-utility evaluation of adjuvant hormonal options in postmenopausal women with breast cancer: tamoxifen vs. anastrazole vs. tamoxifen then exemestane [abstract no. 5036]. Breast Cancer Res Treat 2005; 94 Suppl. 1: 217-8. Plus poster presented at the 28th Annual San Antonio Breast Cancer Symposium; 2005 Dec 8-11; San Antonio (TX)
    • (2005) 28th Annual San Antonio Breast Cancer Symposium
    • Skedgel, C.1    Rayson, D.2    Dewar, R.3
  • 55
    • 33846940693 scopus 로고    scopus 로고
    • Gil JM, Lluch A, González P, et al. Pharmacoeconomic analysis of exemestane versus tamoxifen as adjuvant therapy for patients with early-stage estrogen receptor-positive breast cancer [abstract no. PCN15]. Value Health 2005 Nov-Dec; 8 (6): 37-8. Plus poster presented at the 8th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2005 Nov 6-8; Florence
    • Gil JM, Lluch A, González P, et al. Pharmacoeconomic analysis of exemestane versus tamoxifen as adjuvant therapy for patients with early-stage estrogen receptor-positive breast cancer [abstract no. PCN15]. Value Health 2005 Nov-Dec; 8 (6): 37-8. Plus poster presented at the 8th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2005 Nov 6-8; Florence
  • 56
    • 31544458993 scopus 로고    scopus 로고
    • Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer
    • Feb;
    • Lønning PE. Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer. Ann Oncol 2006 Feb; 17 (2): 217-25
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 217-225
    • Lønning, P.E.1


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