Antagonism of type-1 cannabinoid receptors: Good for obesity, but is it safe for fertility? [3]

Clinical Endocrinology

Volumn 66, Issue 3, 2007, Pages 456-457

  Maccarrone, Mauro ^a   Wang, Haibin ^b   Dey, Sudhansu K ^b  

^a UNIVERSITY OF TERAMO   (Italy)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTOR ANTAGONIST; RIMONABANT;

AMENORRHEA; APPETITE; ATHEROSCLEROSIS; BODY WEIGHT; CARDIOVASCULAR RISK; CLINICAL TRIAL; DRUG SAFETY; DRUG TOLERABILITY; ENERGY BALANCE; FERTILITY; FOOD INTAKE; HUMAN; INFERTILITY; INFLAMMATION; LETTER; OBESITY; OVARY POLYCYSTIC DISEASE; PREGNANCY; PRIORITY JOURNAL; REPRODUCTION; REPRODUCTIVE HEALTH; RISK FACTOR; SAFETY;

ADULT; APPETITE DEPRESSANTS; ENDOCANNABINOIDS; FEMALE; FERTILITY; HUMANS; OBESITY; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1;

EID: 33846918397     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.02760.x     Document Type: Letter

References (5)

1. Van Gaal, L.F., Rissanen, A.M., Scheen, A.J., Ziegler, O., Rossner, S. & RIO-Europe Study Group. (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet, 365, 1389-1397.
2. Pi-Sunyer, F.X., Aronne, L.J., Heshmati, H.M., Devin, J., Rosenstock, J. & RIO-North America Study Group. (2006) Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. Journal of the American Medical Association, 295, 761-775.
3. Pagotto, U., Marsicano, G., Cota, D., Lutz, B. & Pasquali, R. (2006) The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine Reviews, 27, 73-100.
4. Di Marzo, V. & Matias, I. (2005) Endocannabinoid control of food intake and energy balance. Nature Neuroscience, 8, 585-589.
5. Wang, H., Dey, S.K. & Maccarrone, M. (2006) Jekyll and Hyde: two faces of cannabinoid signaling in male and female fertility. Endocrine Reviews, 27, 427-448.