Effects of drying technique on extrusion-spheronisation granules and tablet properties

International Journal of Pharmaceutics

Volumn 332, Issue 1-2, 2007, Pages 38-44

  Song, B ^a   Rough, S L ^a   Wilson, D I ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dissolution; Extrusion spheronisation; Freeze drying; Microcrystalline cellulose; Propyl gallate; Tabletting

Indexed keywords

GALLIC ACID PROPYL ESTER; MICROCRYSTALLINE CELLULOSE; WATER;

ARTICLE; DRUG SOLUBILITY; FREEZE DRYING; PARTICLE SIZE; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET MANUFACTURE; TABLET PROPERTY; TENSILE STRENGTH; ULTRAVIOLET SPECTROSCOPY;

ANTIOXIDANTS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DELAYED-ACTION PREPARATIONS; DESICCATION; EXCIPIENTS; FREEZE DRYING; KINETICS; MODELS, BIOLOGICAL; PARTICLE SIZE; POROSITY; POWDERS; PROPYL GALLATE; SOLUBILITY; SURFACE PROPERTIES; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 33846915340     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.050     Document Type: Article

References (9)

1. Bashaiwoldu A.B., Podczeck F., and Newton J.M. A study on the effect of drying techniques on the mechanical properties of pellets and compacted pellets. Eur. J. Pharm. Sci. 21 (2004) 119-129
2. Bataille B., Ligarski K., Jacob M., Thomas C., and Duru C. Study of the influence of spheronisation and drying conditions on the physico-mechanical properties of neutral spheroids containing Avicel PH 101 and lactose. Drug Dev. Ind. Pharm. 19 (1993) 653-671
3. Dyer A.M., Khan K.A., and Aulton M.E. Effect of the drying method on the mechanical and drug-release properties of pellets prepared by extrusion-spheronisation. Drug Dev. Ind. Pharm. 20 (1994) 3045-3068
4. Johansson B., Wikberg M., Ek R., and Alderborn G. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties. Int. J. Pharm. 117 (1995) 57-73
5. Kleinebudde P. Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose. I: Shrinking properties. Int. J. Pharm. 109 (1994) 209-219
6. Kleinebudde P. Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose. II: Swelling properties. Int. J. Pharm. 109 (1994) 221-227
7. Kuentz M., and Leuenberger H. A new theoretical approach to tablet strength of a binary mixture consisting of a well and poorly compactable substance. Eur. J. Pharm. Biopharm. 49 (2000) 151-159
8. Tomer G., Podczeck F., and Newton J.M. The influence of model drugs on the preparation of pellets by extrusion/spheronisation. II: Spheronisation parameters. Int. J. Pharm. 231 (2002) 107-119
9. Wilson D.I., and Rough S.L. Extrusion-spheronisation. In: Salman A.D., Hounslow M.J., and Seville J.P.K. (Eds). Handbook of Powder Technology: Granulation vol. II (2007), Elsevier, London