Synthesis and in vitro evaluation of targeted tetracycline derivatives: Effects on inhibition of matrix metalloproteinases

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 6, 2007, Pages 2368-2374

  Vidal, Aurélien ^a,b,c   Sabatini, Massimo ^d   Rolland Valognes, Gaëlle ^d   Renard, Pierre ^d   Madelmont, Jean Claude ^a,b,c   Mounetou, Emmanuelle ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c CENTRE JEAN PERRIN   (France)

^d INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Metalloproteinases; Osteoarthritis; Quaternary ammonium; Tetracyclines

Indexed keywords

1,4,4A,5,5A,6,11,12A OCTAHYDRO 2 AMINOCARBONYL 3,5,10,12,12A HEXAHYDROXY 6 METHYL 1,11 DIOXONAPHTHACENE 4 TRIMETHYLAMMONIUM IODIDE; 1,4,4A,5,5A,6,11,12A OCTAHYDRO 2 AMINOCARBONYL 3,6,10,12,12A HEXAHYDROXY 6 METHYL 1,11 DIOXONAPHTHACENE 4 TRIMETHYLAMMONIUM IODIDE; COLLAGENASE 3; DOXYCYCLINE; STROMELYSIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHONDROPROTECTION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACODYNAMICS;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROSARCOMA; COLLAGEN; HUMANS; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; PROTEOGLYCANS; RABBITS; TETRACYCLINES;

EID: 33846912048     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.026     Document Type: Article

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